A5086317200- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Renal and related cancers
- Medical Imaging and Pathology Studies
- Congenital Anomalies and Fetal Surgery
- COVID-19 and healthcare impacts
- Cancer, Hypoxia, and Metabolism
- Hemodynamic Monitoring and Therapy
- Childhood Cancer Survivors' Quality of Life
- Hormonal Regulation and Hypertension
- Central Venous Catheters and Hemodialysis
- COVID-19 Clinical Research Studies
- Urinary and Genital Oncology Studies
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
Mayo Clinic
2024
The University of Texas Southwestern Medical Center
2021-2024
Mayo Clinic in Florida
2024
Children's National
2015-2018
University of California, Irvine
2018
Children's Hospital of Orange County
2018
George Washington University
2015-2018
St. Louis Children's Hospital
2008
Washington University Medical Center
2008
<ns4:p>Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often first indication of a pleiotropic cancer predisposition, <ns4:italic>DICER1</ns4:italic> syndrome, comprising range other individually rare, benign malignant tumors childhood early adulthood. The genetics <ns4:italic>DICER1</ns4:italic>-associated tumorigenesis are unusual in that typically bear neomorphic missense mutations at one five specific “hotspot” codons within RNase IIIb domain...
<ns4:p>Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often first indication of a pleiotropic cancer predisposition, <ns4:italic>DICER1</ns4:italic> syndrome, comprising range other individually rare, benign malignant tumors childhood early adulthood. The genetics <ns4:italic>DICER1</ns4:italic>-associated tumorigenesis are unusual in that typically bear neomorphic missense mutations at one five specific “hotspot” codons within RNase IIIb domain...
Anaplastic sarcoma of the kidney (ASK) is a DICER1-related neoplasm first identified as distinctive tumor type through evaluation unusual cases putative anaplastic Wilms tumors. Subsequent case reports presence biallelic DICER1 variants well progression from cystic nephroma, benign neoplasm. Despite increasing recognition ASK distinct entity, optimal treatment remains unclear.
DICER1-related tumor predisposition increases risk for a spectrum of benign and malignant tumors. In 2018, the International Pleuropulmonary Blastoma (PPB)/DICER1 Registry published guidelines testing- imaging-based surveillance individuals with known or suspected germline DICER1 pathogenic likely (P/LP) variant. One goals is to continue refine these as additional data become available.
The risk of the novel coronavirus disease 2019 (COVID-19) to pediatric oncology patients is unknown. Here, we report eight receiving active cancer therapy that tested positive for COVID-19. Three developed severe cardiorespiratory symptoms (as defined by evidence heart failure echocardiogram and/or intubation secondary respiratory failure), including one death as a result COVID-19 infection. We identified prior anthracycline exposure and pre-COVID cardiac function significantly associated...