A5085849001- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Congenital Diaphragmatic Hernia Studies
- Histiocytic Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Pharmaceutical studies and practices
- Mast cells and histamine
- Neuroblastoma Research and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Testicular diseases and treatments
- Lysosomal Storage Disorders Research
- Meningioma and schwannoma management
- Molecular Biology Techniques and Applications
- Soft tissue tumor case studies
- Ethics in Clinical Research
- Social and Educational Sciences
- Genomics and Rare Diseases
- Myasthenia Gravis and Thymoma
- Clostridium difficile and Clostridium perfringens research
- Musculoskeletal synovial abnormalities and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bacterial Identification and Susceptibility Testing
- AI in cancer detection
Children's Minnesota
2020-2025
Minnesota West Community & Technical College
2022-2024
University of Colorado Denver
2015-2023
Grady Health System
2019
Mayo Clinic in Arizona
2019
Children's Hospital Colorado
2018
Children's Oncology Group
2007
National Cancer Institute
2007
PURPOSE Sertoli-Leydig cell tumors (SLCTs) are rare sex cord-stromal tumors, representing <0.5% of all ovarian tumors. We analyze the role germline DICER1 status in outcomes SLCT. METHODS Patients with SLCT were enrolled International Pleuropulmonary Blastoma/ Registry and/or Ovarian and Testicular Stromal Tumor Registry. Medical records systematically abstracted, those known selected for analysis. RESULTS Of 162 patients SLCT, 60% had a pathogenic or likely (P/LP) variant. The adjusted...
Aim: To assess the performance characteristics of a lab-developed multiplex PCR assay for detection common bacterial pathogens associated with infections in pediatric patients from normally sterile sites, such as cerebrospinal fluid, synovial and pleural fluids. Materials & methods: A total 272 specimens were tested by traditional culture methods to presence Neisseria meningitidis, Streptococcus pneumoniae, pyogenes, methicillin-sensitive methicillin-resistant Staphylococcus aureus Kingella...
DICER1-related tumor predisposition increases risk for a spectrum of benign and malignant tumors. In 2018, the International Pleuropulmonary Blastoma (PPB)/DICER1 Registry published guidelines testing- imaging-based surveillance individuals with known or suspected germline DICER1 pathogenic likely (P/LP) variant. One goals is to continue refine these as additional data become available.
Abstract Activating variants of the MAPK pathway have been found in some Langerhans cell histiocytosis (LCH) lesions. Inhibition with trametinib (MEK inhibitor) has shown to induce responses LCH patients. Two adolescent males driven by BRAF p.N486_P490del received for >1 year no reactivation one and partial response another (including stable lung disease). A third male neonatal MAP2K1 p.K57_G61del had a complete active disease after 22 months. All patients continue on monotherapy...
Neurotrophic receptor tyrosine kinase (NTRK) fusion testing has both diagnostic and therapeutic implications for patient care. With 2 tumor-agnostic US Food Drug Administration-approved tropomyosin (TRK) inhibitors, is increasingly used decision making. However, the landscape NTRK fusions complex, optimal depends on clinicopathologic scenario.To compare different methods to help pathologists understand test features performance characteristics make appropriate selections detection their...
Abstract BACKGROUND Molecular characterization of pediatric CNS tumors improves diagnostic accuracy and guides treatment. Germline analysis is also important to uncover cancer predisposition syndromes, which influence the approach treatment tumor surveillance. The options for molecular assessment are influenced by availability, including access through a trial or insurance approval. METHODS A retrospective review workup performed on all biopsied/resected at Children’s Minnesota from 2019 –...
6632 NCI has developed a central IRB (PedCIRB) to review NCI-sponsored pediatric clinical trials conducted by the Children's Oncology Group (COG). COG comprises ∼200 U.S. medical institutions and protocol activation traditionally requires separate each local (LIRB) and, subsequently, of amendment significant adverse event. The PedCIRB model seeks increase patient protection improving expertise reviewers making their available all participating institutions. consists experts in oncology,...
Langerhans Cell Histiocytosis (LCH) is characterized by activating variants of the MAPK pathway. Inhibition pathway with trametinib (MEK inhibitor) has been shown to induce responses in LCH patients. Two adolescent males driven BRAF p.N486_P490del have received for >1 year no reactivation one and partial response another (including stable lung disease). A third male neonatal MAP2K1 p.K57_G61del had a complete active disease after 22 months. All patients continue on monotherapy tolerable skin...
Abstract Molecular analysis of pediatric CNS tumors helps confirm the diagnosis, but can also guide treatment by identifying prognostic factors allowing for stratification, and unveiling active signaling pathways which be targeted. This report is a retrospective review molecular performed on all biopsied or resected at Children’s Minnesota over last 3 years to evaluate our current practices. From 2019-2021, 118 patients with newly diagnosed underwent surgery followed assessment (14 IHC/FISH,...