A5036390717- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Retinal Development and Disorders
- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Cellular Mechanics and Interactions
- Axon Guidance and Neuronal Signaling
- Microtubule and mitosis dynamics
- Cell Adhesion Molecules Research
- Cellular transport and secretion
- Signaling Pathways in Disease
- Neuroscience and Neuropharmacology Research
Universitat de Barcelona
2020-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2025
Massachusetts Eye and Ear Infirmary
2024
Harvard University
2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2023
Instituto de Salud Carlos III
2023
Neurosciences Institute
2022
Vall d'Hebron Institut de Recerca
2020
Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and highly exacerbated in neurodegenerative diseases. It plays dual role the central nervous system, promoting repair acute stages while aggravating disease progression contributing to neuronal loss, synaptic dysfunction, glial dysregulation chronic phases. Inflammatory responses are mainly orchestrated microglia infiltrated monocytes, which, when dysregulated, not only harm existing neurons,...
Abstract Neural cell adhesion molecule 2 (NCAM2) is involved in the development and plasticity of olfactory system. Genetic data have implicated NCAM2 gene neurodevelopmental disorders including Down syndrome autism, although its role cortical unknown. Here, we show that while overexpression hippocampal neurons leads to minor alterations, downregulation severely compromises dendritic architecture, leading an aberrant phenotype shorter trees, retraction dendrites, emergence numerous somatic...
Abstract Adult neurogenesis persists in mammals the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning memory tasks. Relevant structural elements of niches include family cell adhesion molecules (CAMs), which participate signal transduction regulate survival, division, differentiation radial glial progenitors (RGPs). Here we analyzed functions neural molecule 2 (NCAM2) regulation RGPs adult during corticogenesis. We...
Neuronal cell adhesion molecule 2 (NCAM2) is a membrane protein with an important role in the morphological development of neurons. In cortex and hippocampus, NCAM2 essential for proper neuronal differentiation, dendritic axonal outgrowth synapse formation. However, little known about functional mechanisms its interactive partners during brain development. Here we used mass spectrometry to study molecular interactome second postnatal week mouse cerebral cortex. We found that interacts...
Prime editing (PE) is a CRISPR-based tool for genome engineering that can be applied to generate human induced pluripotent stem cell (hiPSC)-based disease models. PE technology safely introduces point mutations, small insertions, and deletions (indels) into the genome. It uses Cas9-nickase (nCas9) fused reverse transcriptase (RT) as an editor guide RNA (pegRNA), which desired edit with great precision without creating double-strand breaks (DSBs). leads minimal off-targets or indels when...
Adult neurogenesis persists in mammals the neurogenic zones where newborn neurons are incorporated into existing neuronal circuits. Relevant molecular elements of niches include family Cell Adhesion Molecules (CAM), which participate signal transduction and regulate radial glial progenitor's (RGPs) survival, division differentiation. The Neural Molecule 2 (NCAM2) is expressed brain development adult stages, controls dendrite arborisation synaptic formation maintenance during development....