A5080477741- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Folate and B Vitamins Research
- Viral Infections and Vectors
- Cleft Lip and Palate Research
- dental development and anomalies
- Vitamin D Research Studies
- Craniofacial Disorders and Treatments
- Vitamin C and Antioxidants Research
- Wnt/β-catenin signaling in development and cancer
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Radiation Therapy and Dosimetry
- Mosquito-borne diseases and control
- NF-κB Signaling Pathways
- Genomics and Rare Diseases
- Ubiquitin and proteasome pathways
- Anatomy and Medical Technology
- IL-33, ST2, and ILC Pathways
- Cerebrovascular and genetic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Surgical Sutures and Adhesives
Tulane University
2019-2025
Geriatric Research Education and Clinical Center
2020
Stanford University
2014-2020
VA Palo Alto Health Care System
2020
Sri Ramachandra Institute of Higher Education and Research
2019
Qatar Airways (Qatar)
2018
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2010-2014
Introduction: SARS-CoV-2 causes various neurological sequelae in COVID-19 survivors including fatigue and cognitive dysfunction. Endothelial dysfunction, a key mechanism illness, is also major risk factor for vascular dementia (VaD). Clinical evidence suggests that reduced nitric oxide (NO) bioavailability likely pathogenic of endothelial dysfunction patients, eNOS levels decline with advancing age, both morbidity VaD . We hypothesize synthase (eNOS) deficiency contributes to brain infection...
Craniosynostosis is a congenital defect characterized by the premature fusion of calvarial bones, often attributed to loss fibrous sutures or deregulated bone formation. Recent studies have reported abnormal cartilage formation in multiple synostosis models, suggesting potential role for suture and maintenance. The tectum transversum (TTR) transient located between coronal dura, adjacent frontal parietal bones. Abnormal TTR has been observed several models; however, its development remains...
Abstract Genetic variants in micro‐RNAs (miRNA) have been shown to affect progression, diagnosis, and prognosis of various malignancies; however, their role esophageal squamous cell carcinoma (ESCC) susceptibility is controversial. Therefore, we aimed determine common genetic cancer related pre‐miRNA survival outcome north Indian ESCC patients. We genotyped four polymorphisms pre‐miRNA: mir‐196a‐2C>T, mir‐146aG>C, mir‐499T>C, mir‐423C>A 289 incident cases (including 153 follow‐up...
Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are characterized by joint hypermobility, subluxations dislocations, hyperextensible skin, chronic progressive multiorgan comorbidities. Diagnosing hEDS HSD is difficult because of variable phenotypes unknown genetic etiology. In our clinic, we observed many patients with a high serum level unmetabolized folate, which suggests that may be linked to methylenetetrahydrofolate reductase (MTHFR)-mediated folate...
Abstract Background Caspase8 influences carcinogenesis through regulation of apoptosis, hyperproliferation, and metastasis. Role genetic variations in caspase8 has been explored various cancers; however, their predictive prognostic role esophageal cancer is poorly understood. Methods We investigated the association two potential polymorphisms: CASP8 −652 6N del IVS12‐19 G>A polymorphisms with susceptibility survival 259 squamous cell carcinoma (ESCC) cases cancer‐free controls from...
Tumour necrosis factor-alpha (TNF-α) and nuclear factor of kappa light chain gene enhancer in activated B cells (NF-κB) play critical role carcinogenesis processes like tumour initiation, proliferation, migration invasion. Single nucleotide polymorphisms TNF-α, NF-κB its inhibitor IκB genes were shown to be associated with susceptibility prognosis several cancers; however, their esophageal squamous cell carcinoma (ESCC) is not well recognised. Therefore, present study, we aimed investigate...
Background: Phospholipase C epsilon 1 (PLCE1) encodes a member of the phospholipase family proteins that play crucial roles in carcinogenesis and progression several cancers including esophageal cancer (EC). In two large scale genome-wide association studies (GWAS) single nucleotide polymorphisms (SNP, rs2274223A>G, rs3765524C>T) PLCE1 were identified as novel susceptibility loci (EC) China. The aim present study was to investigate this finding Kashmir Valley, high risk area. Materials...
Early diagnosis and better prognosis of esophageal squamous cell carcinoma (ESCC) is still a challenge. Besides environmental risk factors, nutritional deficiencies have an established role in pathogenesis ESCC. Folate deficiency functional polymorphisms folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C>T may oncogenic through disruption normal DNA methylation pattern, synthesis, impaired repair. MTHFR677C>T or A222V (rs1801133) polymorphism has conflicting...
Recent genome-wide association studies (GWAS) have identified variants in phospholipase C epsilon1 (PLCE1) as novel susceptibility markers for esophageal squamous cell carcinoma (ESCC) Chinese population. Although few replicated this findings other populations, but results are contradictory. So, we aimed to replicate of two previously reported non-synonymous polymorphisms (rs2274223A>G and rs3765524C>T) from haplotype block 10 evaluated a variant (rs7922612C>T) 2 PLCE1 with prognosis ESCC...
Abstract Familial Mediterranean fever (FMF) is the most common auto‐inflammatory disease. It transmitted as autosomal recessive trait with mutations in MEditerranean FeVer ( MEFV) gene. Despite a typical clinical expression, many patients have either single or no mutation MEFV . The current work aimed to revisit genetic landscape of FMF disease using high‐coverage whole genome sequencing. In atypical (carrying ), we revealed rare variants genes associated disorders, and more interestingly,...
Mammalian calvarium is composed of flat bones developed from two origins, neural crest, and mesoderm. Cells both origins exhibit similar behavior but express distinct transcriptomes. It intriguing to ask whether genes shared by play or roles in development. In the present study, we have examined role Pdgfra, which expressed crest mesoderm, specific lineages during calvarial
Introduction: Although SARS-CoV-2 infection can cause a wide range of mild to severe symptoms, the pathophysiology acute and long-term neurological manifestations remains elusive. The arginine-glycine-aspartic acid motif viral spike protein may use bind integrins receptors in CNS, which play an important role cerebrovascular integrity. Here we investigate integrin α5β1 mediating brain endothelial damage inflammation during infection. Method: Mouse microvascular cells (bEnd.3) were treated...
Abstract Background SARS‐CoV‐2 causes a variety of neurological sequelae in COVID‐19 survivors, including fatigue and cognitive dysfunction. Endothelial dysfunction is the unifying central mechanism illness major risk factor for vascular dementia (VaD). stems, part, from an imbalance between nitric oxide (NO) generated by endothelial synthase (eNOS) reactive oxidant species produced uncoupled‐eNOS. Clinical observations suggest that decreased NO bioavailability appears as likely pathogenic...