A5047386574- Biochemical and Molecular Research
- Synthesis and Characterization of Heterocyclic Compounds
- HIV/AIDS drug development and treatment
- Synthesis and Reactions of Organic Compounds
- Cancer Treatment and Pharmacology
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
- Software Testing and Debugging Techniques
- Metal complexes synthesis and properties
- Biomedical Text Mining and Ontologies
- Advanced Malware Detection Techniques
- Delphi Technique in Research
- Machine Learning in Healthcare
- Quinazolinone synthesis and applications
- Folate and B Vitamins Research
- Carbohydrate Chemistry and Synthesis
- COVID-19 and healthcare impacts
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Bioactive Compounds and Antitumor Agents
- Ethics in Clinical Research
- Plant and Fungal Interactions Research
University of Kansas Medical Center
2019-2024
The University of Kansas Cancer Center
2019-2024
University of Arizona
2003
IBM (Canada)
1999-2002
SRI International
1980-1987
Menlo School
1981-1987
University of Sussex
1984
Brigham Young University
1983
Newport Hospital
1977-1978
University of Toronto
1970
The antiviral activity of the synthetic nucleoside, Virazole (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), against measles virus in Vero cell cultures was substantially reversed by xanthosine, guanosine, and to a slightly lesser extent inosine. 5′-phosphate subsequently found be potent competitive inhibitor inosine dehydrogenase (IMP:NAD + oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli ( K m = 1.8 × 10 -5 M) with i 2.7 -7 M. Guanosine (GMP) this enzyme 7.7 similarly active...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiviral activity of certain thiazole C-nucleosidesPrem C. Srivastava, Michael V. Pickering, Lois B. Allen, David G. Streeter, Marie T. Campbell, Joseph Witkowski, Robert W. Sidwell, Roland K. RobinsCite this: J. Med. Chem. 1977, 20, 2, 256–262Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February...
Abstract A number of new hypoxanthine analogs have been prepared as substrate inhibitors xanthine oxidase. Most noteworthy inhibitory are 3‐( m ‐tolyl)pyrazolo[1,5‐ a ]pyrimidin‐7‐one ( 47 ), ID 50 0.06 μ M and 3‐phenylpyrazolo[1,5‐ 46 0.40 M. 5‐( p ‐Chlorophenyl)pyrazolo[1,5‐ 63 ) the corresponding 5‐nitrophenyl derivative 64 exhibited an 0.21 0.23 , respectively. 7‐Phenylpyrazolo[1,5‐ ]‐ s ‐triazin‐4‐one 40 is shown to exhibit 0.047 The structure‐activity relationships these phenyl...
Java programs are routinely transmitted over low-bandwidth network connections as compressed class file archives (i.e., zip files and jar files). Since archive size is directly proportional to download time, it desirable for applications be small possible. This paper concerned with the use of program transformations such removal dead methods fields, inlining method calls, simplification hierarchy reducing application size. Such "extraction" techniques generally believed especially useful...
Abstract— The irradiation of TMV with u.v. light 2537 Å wavelength results in the binding protein subunits to RNA. These bound are stable towards warm sodium dodecyl‐sulfate; however, is not covalent since removed by 66% acetic acid, guanidine hydrochloride, or phenol. Approximately one subunit per lethal biological ‘hit’. virus and nucleic acid extracted from irradiated show virtually identical rates inactivation.
Reducing application size is important for software that distributed via the internet, in order to keep download times manageable, and domain of embedded systems, where applications are often stored (Read-Only or Flash) memory. This paper explores extraction techniques such as removal unreachable methods redundant fields, inlining method calls, transformation class hierarchy reducing size. We implemented a number Jax , an extractor Java, evaluated their effectiveness on set large Java...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorylation of ribavirin by deoxyadenosine kinase from rat liver. Differentiation between adenosine and kinaseDavid G. Streeter, Lionel N. Simon, Roland K. Robins, Jon P. MillerCite this: Biochemistry 1974, 13, 22, 4543–4549Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/bi00719a011https://doi.org/10.1021/bi00719a011research-articleACS...
Starting with AICA ribonucleoside the following nucleosides were prepared. Methyl 5-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazole-4-carboxylate (5) was converted into methyl 5-chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazole-4-carboxylate (6) via diazotization in presence of cuprous chloride. Similarly, 5-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuanosyl)imidazole-4-carbonitrile (9) 5-chloro-, 5-bromo-, and...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of transfer ribonucleic acid methylase activity from several human tumors by nicotinamide and analogsLoraine Buch, David Streeter, R. M. Halpern, L. N. Simon, G. Stout, A. SmithCite this: Biochemistry 1972, 11, 3, 393–397Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://doi.org/10.1021/bi00753a015RIGHTS & PERMISSIONSArticle Views40Altmetric-Citations26LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew class of potent guanine antimetabolites. Synthesis 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure imidazole precursorsP. Dan Cook, Robert J. Rousseau, A. Mohsin Mian, Rich B. Meyer Jr., Phoebe Dea, George Ivanovics, David G. Streeter, Joseph T. Witkowski, Mason Stout, Cite this: Am. Chem. Soc. 1975, 97, 10, 2916–2917Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published...
Approximately 40% of patients with cancer are eligible for check-point inhibitor (CPI) therapy. Little research has examined the potential cognitive impact CPIs. First-line CPI therapy offers a unique opportunity without chemotherapy-related confounders. The purpose this prospective, observational pilot was to (1) demonstrate feasibility prospective recruitment, retention, and neurocognitive assessment older adults receiving first-line CPI(s) (2) provide preliminary evidence changes in...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiviral enzymic studies of certain 3-deazaguanines their imidazolecarboxamide precursorsP. Dan Cook, Lois B. Allen, David G. Streeter, John H. Huffman, Robert W. Sidwell, Roland K. RobinsCite this: J. Med. Chem. 1978, 21, 12, 1212–1218Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransfer ribonucleic acid methylase activity in the developing pig brainKenneth R. Swiatek, David G. Streeter, and Lionel N. SimonCite this: Biochemistry 1971, 10, 13, 2563–2567Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/bi00789a023https://doi.org/10.1021/bi00789a023research-articleACS PublicationsRequest reuse permissionsArticle...
ABSTRACT The sensitivities of U(1) and U(2) TMV strains to inactivation by ultraviolet light at 253.7 nm were compared with those hybrid viruses obtained reconstituting the protein either native strain RNA other. In each case, virus was found be virtually identical in sensitivity which supplied coat, indicating that relative two are solely a function their respective coats. Amino acid analysis U (2) reveals about thirteen or fourteen amino replacements (1) strain, is agreement earlier...
Electronic health records (EHR) represent a rich resource for conducting observational studies, supporting clinical trials, and more. However, much of the data contains unstructured text, presenting an obstacle to automated extraction. Natural language processing (NLP) can structure learn from but NLP algorithms were not designed unique characteristics EHR. Here, we propose Relevant Word Order Vectorization (RWOV) aid with structuring. RWOV is based on finding positional relationship between...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and enzymic activity of 1,2,4-triazole-3-carboxamide 6'-deoxyhomoribonucleoside-6'-phosphonic acid related compoundsMercedes Fuertes, Joseph T. Witkowski, David G. Streeter, Roland K. RobinsCite this: J. Med. Chem. 1974, 17, 6, 642–645Publication Date (Print):June 1, 1974Publication History Published online1 May 2002Published inissue 1 June...