A5075169145- Synthesis and Characterization of Heterocyclic Compounds
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- Synthesis and Reactivity of Sulfur-Containing Compounds
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe tosylation of alcoholsGeorge W. Kabalka, Manju Varma, Rajender S. Prem C. Srivastava, and Furn F. Knapp Jr.Cite this: J. Org. Chem. 1986, 51, 12, 2386–2388Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/jo00362a044https://doi.org/10.1021/jo00362a044research-articleACS PublicationsRequest reuse permissionsArticle Views11753Altmetric-Citations172LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiviral activity of certain thiazole C-nucleosidesPrem C. Srivastava, Michael V. Pickering, Lois B. Allen, David G. Streeter, Marie T. Campbell, Joseph Witkowski, Robert W. Sidwell, Roland K. RobinsCite this: J. Med. Chem. 1977, 20, 2, 256–262Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February...
The relative in vitro antiviral activities of three related nucleoside carboxamides, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), and selenazole (2-beta-D-ribofuranosylselenazole-4-carboxamide), were studied against selected DNA RNA viruses. Although the activity different viruses varied, it was significantly more potent than all tested representatives families Paramyxoviridae (parainfluenza virus type 3, mumps...
Treatment of 2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl-1-carbonitrile with hydrogen selenide provided 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonselenoamide (3). Compound 3 was treated ethyl bromopyruvate to provide 2-(2,3,5-tri-O-benzoyl-D-ribofuranosyl)selenazole-4-carboxylates, which after ammonolysis were converted 2-beta-D-ribofuranosylselenazole-4-carboxamide (6) and its alpha-analogue 7, respectively. Acetylation nucleoside 6...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-.beta.-D-ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastasesR. K. Robins, P. C. Srivastava, V. L. Narayanan, J. Plowman, D. PaullCite this: Med. Chem. 1982, 25, 2, 107–108Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/jm00344a002https://doi.org/10.1021/jm00344a002research-articleACS...
2-Methylthio-ADP and its radioactive analogue [beta-32P]2-methylthio-ADP were synthesized used to investigate platelet receptors for ADP. induced aggregation shape change, inhibited cyclic AMP accumulation in platelets exposed prostaglandin E1. Compared with ADP, 2-methylthio-ADP was 3-5 times as active an aggregating agent 150-200 inhibitor of accumulation. Binding measured after centrifuging them through silicone oil separate from their suspension medium. reversible, saturable, specific,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of 2-azidoadenosine [.beta.-32P]diphosphate to the receptor on intact human blood platelets which inhibits adenylate cyclaseDonald E. Macfarlane, David C. B. Mills, and Prem SrivastavaCite this: Biochemistry 1982, 21, 3, 544–549Publication Date (Print):February 2, 1982Publication History Published online1 May 2002Published inissue 2 February...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural studies of a new antitumor agent: tiazofurin and its inactive analogsBarry M. Goldstein, Fusao Takusagawa, Helen Berman, Prem C. Srivastava, Roland K. RobinsCite this: J. Am. Chem. Soc. 1983, 105, 25, 7416–7422Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00363a035https://doi.org/10.1021/ja00363a035research-articleACS...
Starting with AICA ribonucleoside the following nucleosides were prepared. Methyl 5-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazole-4-carboxylate (5) was converted into methyl 5-chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazole-4-carboxylate (6) via diazotization in presence of cuprous chloride. Similarly, 5-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuanosyl)imidazole-4-carbonitrile (9) 5-chloro-, 5-bromo-, and...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural studies of a new antitumor and antiviral agent: selenazofurin its .alpha. anomerBarry M. Goldstein, Fusao Takusagawa, Helen W. Berman, Prem C. Srivastava, Roland K. RobinsCite this: J. Am. Chem. Soc. 1985, 107, 5, 1394–1400Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00291a047https://doi.org/10.1021/ja00291a047research-articleACS...
Abstract 2′‐Deoxy‐D‐ribonucleoside analogs of biologically active 2‐β‐D‐ribofuranosylthiazole‐4‐carboxamide were synthesized and the structure β anomer was determined by X‐ray crystallography ′ 1 H nmr. 2′‐Methylene protons α‐ β‐deoxyribonucleosides observed to exhibit characteristic patterns in nmr which used distinguish between two anomers. The method could be determine anomeric configuration both N‐ C ‐2′‐deoxyribonucleosides.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleoside Peptides. 6. Synthesis of Certain N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]amino Acids Related to Naturally Occurring Intermediates in the Purine Biosynthetic PathwayPrem Srivastava, Robert Mancuso, Rousseau, and Roland RobinsCite this: J. Med. Chem. 1974, 17, 11, 1207–1211Publication Date (Print):November 1, 1974Publication History Published online14 August 2003Published inissue 1 November...
Phosphorylation of 2-beta-D-ribofuranosylthiazole-4-carboxamide (1) provided the 5'-phosphate 2, which was converted to corresponding 5'-triphosphate 4 and cyclic 3',5'-phosphate 5. Treatment 2-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)thiazole-4-carbonitrile (6) with NH3-NH4Cl 2-beta-D-ribofuranosylthiazole-4-carboxamidine hydrochloride (7), treatment H2S-pyridine 4-thiocarboxamide 9. Compound 9 treated ethyl bromopyruvate, followed by methanolic ammonia, yield...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-substituted derivatives 5-amino-1-.beta.-D-ribofuranosylimidazole-4-carboxamide. Ring opening reactions 2-azapurine nucleosidesGeorge A. Ivanovics, Robert J. Rousseau, Masajiro Kawana, Prem C. Srivastava, and Roland K. RobinsCite this: Org. Chem. 1974, 39, 25, 3651–3654Publication Date (Print):December 1, 1974Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential cerebral perfusion agents: synthesis and evaluation of a radioiodinated vinylalkylbarbituric acid analogPrem C. Srivastava, Alvin P. Callahan, Evelyn B. Cunningham, Furn F. Knapp Jr.Cite this: J. Med. Chem. 1983, 26, 5, 742–746Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 1983https://pubs.acs.org/doi/10.1021/jm00359a020https://doi.org/10.1021/jm00359a020research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2',5'-Oligoadenylates and related 2',5'-oligonucleotide analogs. 1. Enzymic synthesis substrate specificity of the interferon-induced murine 2',5'-oligoadenylate synthetaseBronwyn G. Hughes, Prem C. Srivastava, Derek D. Muse, Roland K. RobinsCite this: Biochemistry 1983, 22, 9, 2116–2126Publication Date (Print):April 26, 1983Publication History Published online1 May 2002Published inissue 26 April...
Abstract Vinyl halides have proven to be useful synthetic intermediates.1,2 Recently, it was discovered that vinyl iodides are more stable in-vivo deiodination than the corresponding alkyl iodides.3,4 This fact makes potentially valuable in design and syntheses of radiopharmaceuticals. Because our interest pharmaceutical design, we recently developed a synthesis which boronic acids allowed react with sodium iodide presence mild oxidizing agents.5 The method has been successfully applied...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleosides of 4-substituted imidazolesPrem C. Srivastava, George A. Ivanovics, Robert J. Rousseau, and Roland K. RobinsCite this: Org. Chem. 1975, 40, 20, 2920–2924Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/jo00908a015https://doi.org/10.1021/jo00908a015research-articleACS PublicationsRequest reuse permissionsArticle...
Birth weight is the most important factor that affects infant and child mortality. This one year study was conducted in a cohort of pregnant women to proportion low birth babies find out socio-economic maternal risk factors affecting newborns its medico-legal significance. Information regarding status, obstetric history present pregnancy collected. These were followed up till their delivery recorded with 24 hours delivery. available for 256 births. The overall prevalence 34.37%. Overall mean...
Phytoextraction has received increasing attention as a promising, cost-effective alternative to conventional engineering-based remediation methods for metal contaminated soils. In order enhance the phytoremediative ability of green plants chelating agents are commonly used. Our study aims evaluate whether, citric acid (CA) or elemental sulfur (S) should be used an ethylene diamine tetraacetic (EDTA)for chemically enhanced phytoextraction. Results showed that EDTA was more efficient than CA...
A rapid iodination method has been developed for the synthesis of new 123I-labeled phosphonium cation [(E)-1-iodo-1-penten-5-yl]triphenylphosphonium iodide by I+ treatment corresponding trans-vinylboronic acid. This model myocardial perfusion agent is obtained after purification in 25-50% yield less than 1 h. High uptake (5 min, 2.38% dose/g) with prolonged retention (3 h, 2.21% was observed rats. In addition, heart/blood ratios were high and continued to increase over a 1-day period 17:1;...