A5069600722- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cytomegalovirus and herpesvirus research
- Gyrotron and Vacuum Electronics Research
- Lung Cancer Research Studies
- Advanced Breast Cancer Therapies
- Gastrointestinal disorders and treatments
- Food Allergy and Anaphylaxis Research
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- Colorectal and Anal Carcinomas
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Cutaneous Melanoma Detection and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Parathyroid Disorders and Treatments
- Eosinophilic Disorders and Syndromes
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
Ospedale Santa Maria
2017
Santa Maria Nuova Hospital
2008-2011
University of Modena and Reggio Emilia
2001-2005
University of Helsinki
2001
Università Cattolica del Sacro Cuore
1999
PURPOSE: Germline mutations in mismatch repair genes predispose to hereditary nonpolyposis colorectal cancer (HNPCC). To address effective screening programs, the true incidence of disease must be known. Previous clinical investigations reported estimates ranging between 0.5% and 13% all (CRC) cases, whereas biomolecular studies Finland found an 2% 2.7% mutation carriers for disease. The aim present report is establish frequency a high-incidence area colon cancer. PATIENTS AND METHODS:...
We selected a 4-stain immunopanel including thyroid transcription factor (TTF)-1, cytokeratin (CK) 7, 34βE12, and CD56/neural cell adhesion molecule (NCAM) to subclassify series of 45 pulmonary large carcinomas (LCCs) on bronchial biopsy. All cases consisted tumor proliferation with abundant cytoplasm, vesicular nuclei, prominent nucleoli. Immunohistochemically, 27 tumors (60%) were subclassified as adenocarcinoma (TTF-1+/CK7+, 24; CK7+ only, 3), 10 (22%) squamous carcinoma (34βE12+ only), 4...
Spitz nevus is a clinico-pathologic entity that can cause diagnostic concern, particularly in adults. Many studies have been performed to establish reliable histologic criteria, the attempt differentiate this lesion from melanoma. A series of 247 nevi, 6 which were formerly classified as melanomas, reviewed for clinical and histopathological parameters. Patients older than 20 comprised 66% cases, with predominance women. The lower extremity was more affected females any age, whereas trunk...
<h3>BACKGROUND</h3> Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common inherited disorders predisposing to cancer. The genes responsible for disease have recently been cloned and characterised; their mutations induce a generalised genomic instability which particularly evident at microsatellite loci (replication error (RER)+ phenotype). <h3>AIMS</h3> To investigate how select individuals families in general population who should be screened constitutional...
Appendiceal carcinoids range from well-differentiated endocrine tumor to carcinoma, while poorly differentiated (small cell) carcinoma has not been described in this site. We report herein a case of mixed intestinal-type adenocarcinoma associated with small cell arisen 35-year-old woman and clinically presenting as an appendiceal abscess. The resected histologically appeared biphasic lesion composed nonmucinous closely juxtaposed carcinoma. subsequent right hemicolectomy was unremarkable,...
Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism gene inactivation during tumorigenesis. We examined the status two distinct regions MLH1 (proximal and distal to transcription start site) expression by methylation‐specific PCR immunohistochemistry. A total 72 colorectal tumors, both with (n = 51, 22 affected hereditary nonpolyposis cancer, HNPCC, defined according international clinical criteria 29 sporadic cases) without microsatellite...
The adoption of neoadjuvant chemotherapy (NACT) for breast cancer (BC) is increasing. need to repeat the biomarkers on a residual tumor after NACT still matter debate. We verified estrogen receptors (ER), progesterone (PR), Ki67 and human epidermal growth factor receptor 2 (HER2) status changes impact in retrospective monocentric series 265 BCs undergoing NACT. All changed with an overall tendency toward reduced expression. Changes PR were statistically significant (p = 0.001). 114/265...
Eosinophilic lung diseases represent a heterogeneous group of disorders with prominent infiltrate eosinophils in interstitium and alveolar spaces. Peripheral blood eosinophilia is often present. Infections, drugs, allergens, toxic agents have to be evaluated as possible causes eosinophilic infiltrates. The category myeloid/lymphoid neoplasms rearrangement PDGFRA, PDGFRB, FGFR1 PCM1-JAK2 represents an uncommon cause infiltrate.We report the case 70-year old man complaining dry cough dyspnea....
The interaction of programmed death-1 (PD-1) on T lymphocytes with its ligands Programmed Death Ligand 1 (PD-L1) and 2 (PD-L2) tumor cells and/or tumor-associated macrophages results in inhibitory signals to the T-cell receptor pathway, consequently causing immune escape. PD-L1/PD-L2 are currently used as predictive tissue biomarkers clinical practice. Virtually PD-L1 levels expressed by associated a good response checkpoint blockade therapies targeting PD-1/PD-L1 axis. These restore...
Abstract: Amyloidosis is a chronic disease characterized by the deposition of fibrils in various tissues and its classification depends mainly on constituents these fibrils. We present c...
We selected a 4-stain immunopanel including thyroid transcription factor (TTF)-1, cytokeratin (CK) 7, 34βE12, and CD56/neural cell adhesion molecule (NCAM) to subclassify series of 45 pulmonary large carcinomas (LCCs) on bronchial biopsy. All cases consisted tumor proliferation with abundant cytoplasm, vesicular nuclei, prominent nucleoli. Immunohistochemically, 27 tumors (60%) were subclassified as adenocarcinoma (TTF-1+/CK7+, 24; CK7+ only, 3), 10 (22%) squamous carcinoma (34βE12+ only), 4...
1028 Background: ASCO/CAP new guidelines published in 2013 (AC2013) significantly modified the scoring criteria for HER2-FISH. We retrospectively evaluated impact of AC2013 a five-year cohort consecutive invasive breast cancers (IBCs) underwent frontline dual-color FISH. Furthermore, we applied three different reflex tests and investigated clinical outcomes patients with HER2-equivocal IBC. Methods: 2788 IBCs that HER2/CEP17 determination our institution from January 2009 to December were...
e12643 Background: Around 40% of HER2-positive (HER2+) breast cancer patients who receive trastuzumab-based neoadjuvant therapy (TNT) achieve pCR (the FDA-recommended outcome measure in this setting). The ability to predict which will respond TNT could support decisions regarding selection agents or combinations. We previously quantified tumor expression HER2 with mass spectrometry archived biopsies received adjuvant trastuzumab; levels > 2200 amol/ug protein were associated superior...
Abstract This abstract was not presented at the conference. Citation Format: Gasparini E, Bisagni A, Di Cicilia R, Kuhn Falco G, Ferrari Foroni M, Tamagnini I, Bassano C, Ragazzi Gardini Cecchi F, Hembrough T, G. Not [abstract]. In: Proceedings of 2018 San Antonio Breast Cancer Symposium; Dec 4-8; Antonio, TX. Philadelphia (PA): AACR; Res 2019;79(4 Suppl):Abstract nr P3-10-24.