A5050477850- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Assays
- Child and Adolescent Psychosocial and Emotional Development
- Attachment and Relationship Dynamics
- Veterinary Equine Medical Research
- Tryptophan and brain disorders
- Sports Performance and Training
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Sodium Intake and Health
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Ion channel regulation and function
Technion – Israel Institute of Technology
2013-2021
University of Haifa
2004-2015
Rappaport Family Institute for Research in the Medical Sciences
2011-2013
The level of controllability has been shown to modulate the effects stress on physiology and behavior. In present study, we investigated controllable vs. uncontrollable stressors plasticity in hippocampal CA1, dentate gyrus (DG), basal amygdala nucleus (B) rat, using electrophysiological procedure long-term potentiation (LTP). A naive group was left undisturbed until recording commenced. Rats two groups were trained Morris water maze locate an invisible underwater platform (the first group),...
Abstract Stress‐sensitive psychopathologies such as post‐traumatic stress disorder are characterized by deficits in fear extinction and dysfunction of corticolimbic circuits mediating extinction. Chronic facilitates conditioning, impairs extinction, produces dendritic proliferation the basolateral amygdala (BLA), a critical site plasticity for Acute alters medial prefrontal cortex‐to‐ BLA circuit, causes retraction cortex. Here, we examined learning pyramidal neuron morphology adult male...
Electrical stimulation of the rodent medial prefrontal cortex (mPFC), including infralimbic (IL), immediately prior to or during fear extinction training facilitates memory. Here we examined effects high-frequency (HFS) rat IL either conditioning following retrieval conditioned memory, on Pavlovian and taste aversion (CTA). IL-HFS applied after memory retrieval, but not three hours conditioning, subsequently reduced freezing extinction. Similarly, given immediately, after, a CTA These data...
Abstract The basolateral amygdala (BLA) has been repeatedly shown to mediate the effects of stress on memory‐related processes. However, way in which influences BLA itself not fully explored. We studied and corticosterone (CORT) activity plasticity rat, using electrophysiological procedure long‐term potentiation (LTP) induction vivo. Rats were exposed an acute elevated‐platform or administered vehicle 5 mg/kg, 10 25 mg/kg CORT systemically, after they anesthetized prepared for field...
Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in central nervous system, resulting neuropsychological cognitive abnormalities. Here we assessed pathological organization that may underlie behavioral impairments NF1 using resting-state connectivity MRI. Coherent spontaneous fluctuations fMRI signal across entire brain were used to interrogate pattern of corticocortical corticostriatal networks both...
Abstract In recent years precision fMRI has emerged in human brain research, demonstrating characterization of individual differences organization. However, mechanistic investigations to the sources variability are limited humans and thus require animal models. Here, we used resting-state awake mice quantify contribution variation functional architecture mouse cortex. We found that connectome is also characterized by stable features support connectivity-based identification. Unlike humans,...
Stressors differ in their physiological and behavioral outcomes. One of the major mechanisms by which stressors affect brain behavior is alteration neuronal plasticity. We investigated rat effects a single exposure to psychophysical (electrical foot shock) vs. psychological (social defeat) on anxiety- depression-related behaviors, serum levels corticosterone expression plasticity-related genes CAM-L1, CREB, GAP-43, laminin prefrontal cortex (PFC), amygdala hippocampus. Rats were examined for...
Dysfunction in corticolimbic circuits that mediate the extinction of learned fear responses is thought to underlie perseveration stress-related psychopathologies, including post-traumatic stress disorder. Chronic produces dendritic hypertrophy basolateral amygdala (BLA) and hypotrophy medial prefrontal cortex, whereas acute leads both BLA prelimbic cortex. Additionally, chronic impair retrieval. Here, we examined effects a single elevated platform on learning morphology infralimbic region...
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. sought to understand the molecular pathophysiology of this goal developing targets for drug intervention. demonstrate here that results interference binding apocalmodulin IQ domain IQSEC2. further constitutive activation guanine nucleotide exchange factor (GEF) activity resulting increased production active form Arf6. In a CRISPR generated mouse model mutation, we surface...
Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss adult oligodendrocytes myelin decompaction and increases oligodendrocyte nitric oxide (NO) levels. Nitric synthase (NOS) inhibitors rescue this pathology. Whether pathology is sufficient to affect brain-wide structure account for NF1 imaging findings unknown. Here we show that...
Abstract IQSEC2 is an X-linked gene that associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex suggested to play role in AMPA trafficking mediation long-term depression. Here, we present brain-wide structural volumetric functional connectivity characterization novel mouse model missense mutation IQ domain (A350V). Using high-resolution MRI, show animals A350V...
Abstract Sucklings (18‐day‐old) and weanlings (35‐day‐old) were injected icv with oxytocin or its antagonist (both 0.5 μg/1 μl), vasopressin (1.0 ng/1 μl) (100 prior to 4‐min observation in a behavioral maze sibling one box their anesthetized dam the other. Oxytocin abolished nipple attachment sucklings, decreased time spent dam, increased self‐grooming. The had little influence on behavior. Vasopressin self‐grooming while reduced passive contact active her, exploration activity. We conclude...
Abstract The functional organization of brain networks can be estimated using fMRI by examining the coherence spontaneous fluctuations in signal, a method known as resting-state connectivity MRI. Previous studies humans reported that such are dominated stable group and individual factors, demonstrating is suited to measuring subject-specific characteristics, suggesting utility precision approach personalized medicine. However, mechanistic investigations sources variability health disease...
ABSTRACT Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in central nervous system, resulting neuropsychological cognitive abnormalities. Here we assessed pathological organization that may underlie behavioral impairments NF1 using resting-state connectivity MRI. Coherent spontaneous fluctuations fMRI signal across entire brain were used to interrogate pattern of corticocortical corticostriatal...
Abstract Neurofibromin gene ( NF1 ) mutation causes Neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss adult oligodendrocyte myelin decompaction, and increases nitric oxide (NO) levels. Nitric synthase (NOS) inhibitors rescue this pathology. Whether pathology is sufficient to affect brainwide structure account for imaging findings unknown. Here, we show that inactivation...
Abstract IQSEC2 is an X-linked gene which associated with autism spectrum disorder (ASD), intellectual disability and epilepsy. a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex suggested to play role in AMPA trafficking mediation long-term depression. Here, we present brain-wide structural volumetric functional connectivity characterization novel mouse model missense mutation IQ domain (A350V). Using high-resolution MRI, show that animals...