A5000417516- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Cholinesterase and Neurodegenerative Diseases
- Urinary and Genital Oncology Studies
- Cerebrovascular and Carotid Artery Diseases
- Renal cell carcinoma treatment
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Chemical synthesis and alkaloids
- Infectious Disease Case Reports and Treatments
- Kidney Stones and Urolithiasis Treatments
- Congenital limb and hand anomalies
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vascular Malformations Diagnosis and Treatment
- Ureteral procedures and complications
- Vascular anomalies and interventions
- Renal and related cancers
- Testicular diseases and treatments
- Computational Drug Discovery Methods
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
Stanford University
2023-2025
Stratford University
2025
Université de franche-comté
2022-2024
Inserm
2024
University of Sfax
2019-2024
Université Bourgogne Franche-Comté
2019
Laboratoire de Chimie Organique
2018
AdventHealth Tampa
2017
El Camino Hospital
2016
Centre Hospito Universitaire de Sétif
2015
Summary— Our experience with 163 patients (11 from our institution) simple epidermoid cyst of the testis was analysed. The lesion is nearly as common interstitial cell tumour testis. In its form it a benign that usually appears solitary, asymptomatic, testicular, 2‐cm mass in non‐black young men (usually 20 to 40 years age). It has been suspected on circumstantial clinical evidence few (17.5%) who have successfully treated by enucleation. majority, however, fear looking for zebra herd horses...
No AccessJournal of Urology1 Aug 1976Observations on Vesical Diverticulum in Childhood David M. Barrett, R.S. Malek, and Panayotis P. Kelalis BarrettDavid Barrett , MalekR.S. Malek KelalisPanayotis View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58760-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail An operation was required 78 children with vesical diverticula the absence bladder outlet obstruction....
Abstract Ferroptosis has emerged as a significant process in cancer biology due to its ability counteract mechanisms of tumor survival and drug resistance. Exploiting this vulnerability is an emerging therapeutic strategy treatment. System xc- plays critical role ferroptosis by regulating the availability cysteine, crucial precursor for glutathione synthesis, thereby influencing cellular antioxidant defense system. We recently reported development validation [18F]hGTS13, radiolabeled...
No AccessJournal of Urology1 Mar 1977Observations on the Ultrastructure and Genesis Urinary Calculi R.S. Malek, W.H. Boyce MalekR.S. Malek More articles by this author , BoyceW.H. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58451-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Conventional scanning electron microscopy calcigerous renal calculi discloses typical concentric laminations, radial...
New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good blockade activity (IC50 = 21 ± 1 μM), potent affinity against hH3R (Ki 565 62 nM), moderate but selective hBuChE 7.83 0.10 strong antioxidant power (3.6 TE), ability to restore cognitive impairment induced lipopolysaccharide.
Twenty patients with renal cell carcinoma in anatomically or functionally solitary kidneys were treated and followed for up to 18 years. Factors pertinent management survival of these 66 other well documented similar reported the literature are analyzed. Most unusually young a significant number had nephrectomy contralateral carcinoma. Survival was closely related earlier presence malignant disease kidney, duration interval between detection 2 neoplasms stage lesion kidney. Partial has been...
Arterial dissections account for 2% of strokes in all age groups, and up to 25% patients aged 45 years or younger. The safety endovascular intervention this patient population is not well characterized. We identified the Merci registry - a prospective, multi-center post-market database enrolling treated with Retriever thrombectomy device arterial dissection as most likely stroke etiology. Stroke presentation procedural details were obtained prospectively; data regarding complications,...
No AccessJournal of Urology1 Jan 1977Management Ruptured Posterior Urethra in Childhood R.S. Malek, M.J. O’Dea, and P.P. Kelalis MalekR.S. Malek More articles by this author , O’DeaM.J. O’Dea KelalisP.P. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58358-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Seven boys with fracture(s) the bony pelvis associated partial or complete rupture posterior urethra...
Acute basilar artery occlusion has a mortality rate approaching 90%. The authors describe case of acute managed successfully with endovascular embolectomy. A 31-year-old man sought treatment for confusion, dysarthria, and right-sided weakness. He soon became unresponsive was found to have vertebral dissection an associated embolism. stenting, the embolus removed clot retriever at 7 hours. patient recovered without neurologic deficit.
At present, one of the most promising strategies to tackle complex challenges posed by Alzheimer's disease (AD) involves development novel multitarget-directed ligands (MTDLs). To this end, we designed and synthesized nine new MTDLs using a straightforward cost-efficient one-pot Biginelli three-component reaction. Among these newly developed compounds, particular small molecule, named 3e has emerged as MTDL. This compound effectively targets critical biological factors associated with AD,...
The presence of congenital para-ureteral diverticulum (PUD) has been presumed to lower the resolution rate vesicoureteral reflux (VUR). PUD is considered an important cause distortion junction and persistence VUR. Early surgery recommended based on this assumption. However, scientific evidence supporting approach weak. We have managing group patients more conservatively in last 7 8 years premise that not per se indication for surgery. To test hypothesis, we performed a retrospective cohort...
No AccessJournal of Urology1 Aug 1976Spontaneous Urinary Extravasation A.U. Khan and R.S. Malek KhanA.U. More articles by this author MalekR.S. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58728-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The diagnosis management 12 patients with spontaneous non-traumatic urinary extravasation are described. It Is important distinguish the fornical backflow type...
Rationale: Despite recent advances in the use of adeno-associated viruses (AAVs) as potential vehicles for genetic intervention central and peripheral nervous system-associated disorders, gene therapy treatment neuropathology adults has not been approved to date.The currently FDA-approved AAV-vector based therapies rely on naturally occurring serotypes, such AAV2 or AAV9, which display limited no transport across blood-brain barrier (BBB) if systemically administered.Recently developed...
In view of the multifactorial nature Alzheimer's disease (AD), multitarget small molecules (MTSM) represent most potent and attractive therapeutic strategy to design new drugs for therapy. The MTSM KojoTacrines (KTs) were designed synthesized by juxtaposition selected pharmacophoric motifs from kojic acid tacrine. Among them, 11-amino-2-(hydroxymethyl)-12-(3-methoxyphenyl)-7,9,10,12-tetrahydropyrano [2',3':5,6] pyrano[2,3-b]quinolin-4(8H)-one (KT2d) was identified as less-hepatotoxic than...
No AccessJournal of Urology1 Oct 1976Urethral Calculi Stephen C. Paulk, Ansar U. Khan, R.S. Malek, and Laurence F. Greene PaulkStephen Paulk More articles by this author , KhanAnsar Khan MalekR.S. Malek GreeneLaurence View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58849-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The diagnosis management 34 men 13 women with urethral calculi are reviewed. A majority...
Novel multitarget-directed ligands BIGI 4a-d and 5a-d were designed synthesized with a simple cost-efficient procedure via one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel antagonism, antioxidant ability. Among these ligands, 4b, 4d, 5b identified as promising new hit compounds showing in vitro balanced activities toward the recognized AD targets. In addition, showed suitable physicochemical properties good druglikeness score...
No AccessJournal of Urology1 Nov 1977Malacoplakia the Urinary Tract: Challenges and Frustrations with 10 Cases M.J. O'Dea, R.S. Malek, G.M. Farrow O'DeaM.J. O'Dea , MalekR.S. Malek FarrowG.M. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58178-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Experience cases malacoplakia urinary tract is reviewed. The bladder was affected in all patients, addition both...
No AccessJournal of Urology1 Sep 1977Paratesticular Rhabdomyosarcoma in Childhood R.S. Malek, and P.P. Kelalis MalekR.S. Malek More articles by this author , KelalisP.P. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58055-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Ten boys with paratesticular embryonal rhabdomyosarcoma were treated a 44-year period. Two prognostically distinct stages the disease...
No AccessJournal of Urology1 Oct 1976Renal Vein Thrombosis M.J. O’Dea, R.S. Malek, R.M. Tucker, and R.E. Fulton O’DeaM.J. O’Dea More articles by this author , MalekR.S. Malek TuckerR.M. Tucker FultonR.E. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58838-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The manifestations, clinical course treatment 14 patients with non-malignant renal vein thrombosis are...
We followed 21 patients with congenital infundibulopelvic stenosis, a rare obstructive disorder of the intrarenal collecting system, for median 11 years (range 2 to 28 years). Of these 19 (90%) had evidence bilateral renal disease. In particular, 10 infundibular pelvic 6 contralateral cystic dysplastic kidney and 3 congenitally absent kidney. Extended observations this revealed that end stage disease or insufficiency developed in 8 (37%), all anomalies. Renal biopsies failure widespread...
Background: Many factors are involved in Alzheimer’s Disease (AD) such as amyloid plaques, neurofibrillary tangles, cholinergic deficit and oxidative stress. To counter the complexity of disease new approach for drug development is to create a single molecule able act simultaneously on different targets. Objective: We conceived eight likeliness compounds targeting inhibition cholinesterases scavenging radicals. Methods: synthesised molecules by Passerini multicomponent reaction evaluated...
No AccessJournal of Urology1 Jul 1976The Stone-Forming Kidney: A Study Functional Differences Between Individual Kidneys in Idiopathic Renal Lithiasis R.S. Malek, R.M. Wilkiemeyer, and W.H. Boyce MalekR.S. Malek Received Traveling Fellowship Award North Central Section, American Urological Association for this study. More articles by author , WilkiemeyerR.M. Wilkiemeyer BoyceW.H. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58652-8AboutPDF ToolsAdd to favoritesDownload...