A5045541487- Head and Neck Cancer Studies
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Lymphatic System and Diseases
- Ethnobotanical and Medicinal Plants Studies
- Bone Metabolism and Diseases
- Cancer-related Molecular Pathways
- Pregnancy and preeclampsia studies
- Single-cell and spatial transcriptomics
- Biotin and Related Studies
- Radiopharmaceutical Chemistry and Applications
- S100 Proteins and Annexins
- Heat shock proteins research
- Natural Compounds in Disease Treatment
- Cardiovascular and Diving-Related Complications
- ATP Synthase and ATPases Research
- TGF-β signaling in diseases
- Medical Malpractice and Liability Issues
Cardiff University
2019-2022
Central Drug Research Institute
2012-2020
Academy of Scientific and Innovative Research
2018-2020
King George's Medical University
2016-2017
The Royal Free Hospital
2017
University College London
2017
Council of Scientific and Industrial Research
2015
Sardar Patel Post Graduate Institute of Dental and Medical Sciences
2011
Boston Children's Hospital
2009
Abstract Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer found its anti-CSC potential. Shk treatment decreased expression various epithelial to mesenchymal transition (EMT) CSC associated markers. Kinase profiling array western blot analysis indicated that inhibits STAT3, FAK Src activation. Inhibition these signaling proteins using standard inhibitors revealed...
// Namrata Rastogi 1 , Shivali Duggal 2 Shailendra Kumar Singh 3 Konica Porwal Vikas Srivastava Rakesh Maurya 4 Madan L.B. Bhatt and Durga Prasad Mishra Cell Death Research Laboratory, Division of Endocrinology, CSIR-Central Drug Institute, Lucknow, India Department Radiotherapy, King George Medical University, Host Defense, WPI Immunology Frontier Center, Osaka Suita, Osaka, Japan Medicinal Process Chemistry Division, Correspondence to: Mishra, email: Keywords : proteasome, p53...
Proteasomes are multicatalytic protease complexes in the cell, involved non-lysosomal recycling of intra-cellular proteins. play a critical role regulation cell division both normal as well cancer cells. In cells this homeostatic function is deregulated leading to hyperactivation proteasomes. Proteasome inhibitors (PIs) class compounds, which either reversibly or irreversibly block activity proteasomes and induce death. Interference PIs with ubiquitin proteasome pathway (UPP) protein...
Abstract Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation NOX2 oxidase, occurs in >60% patients AML and ROS production promotes proliferation cells. We show here the process most significantly affected by glycolysis. Whole metabolome analysis 20 human primary blasts generating high levels have increased glucose uptake...
Abstract The heterogeneous nature of human CD34 + hematopoietic stem cells (HSCs) has hampered our understanding the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell RNA-sequencing extensive xenotransplantation, we have uncovered an uncharacterized HSC population. These EPCR (CD38/CD45RA) − (simply as ) a high repopulating self-renewal abilities, reaching frequency ~1 in 3 cells, highest described to date. Their...
Abstract Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development acute myeloid leukemia (AML), we compared nuclear proteome transcriptome AML blasts human CD34 + cells. Analysis identified networks processes that significantly affected transcription regulation including misexpression 11 factors seven not previously implicated in AML. Transcriptome analysis changes 40 but none these...
Riboflavin (RF) or vitamin B2 is known to have neuroprotective effects. In the present study, we report attenuation of effects RF under UV-B irradiation. Preconditioning irradiated riboflavin (UV-B-RF) showed attenuated compared that in SH-SY5Y neuroblostoma cell line and primary cortical neurons vitro a rat model cerebral ischemia vivo. Results indicated pretreatment significantly inhibited death reduced LDH secretion UV-B-RF neuron cultures subjected oxygen glucose deprivation brain tissue...
Objective: MicroRNAs (miRs) are class of small non-coding regulatory RNA aberrantly expressed in various types malignancies including prostate cancer and serves as potential targets to develop new diagnostic therapeutic strategies. In this quiet we investigated miRNAs expression profile benign prostatic hyperplasia (BPH) (PCa) tissue samples correlated their with clinicopathological parameters. Methodology: The well validation has been done by using Microarray RT-PCR, respectively....
Summary Treatment of relapsed/resistant acute myeloid leukaemia (AML) remains a significant area unmet patient need, the outlook for most patients remaining extremely poor. A promising approach is to augment anti‐tumour immune response in these patients; cancers do not activate effector cells because they express immunosuppressive ligands. We have previously shown that CD200 (an ligand) overexpressed AML and confers an inferior overall survival compared CD200low/neg patients. Here we show...
To evaluate serum VEGF-A levels in squamous cell carcinoma of head and neck (SCCHN) patients relationships with response to therapy.Serum (n=72) treated radiotherapy (RT) or radio-chemotherapy (RCT) controls (n=40) were measured by ELISA.Serum the SCCHN cases significantly higher (p=0.001) than healthy controls, positive as compared negative lymph node status (p=0.004). Similarly, advanced stage (Stage III-IV) disease had more greatly elevated level their early I-II) counterparts (p=0.001)....
The synthesis and SAR studies of 10 new chemical entities (NCEs) that have shown BMP-2 stimulation osteoblast differentiation are reported. Among these, 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)benzoic acid (11) was the most effective while its analogue 13 also showed good activity in inducing production. Compound 11 induced vitro, this effect abrogated by a physiological inhibitor, noggin. It exhibited dose dependent increase nascent bone formation...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
ABSTRACT Cancer is a class of diseases in which cell or group cells display uncontrolled growth, invasion, and sometimes metastasis. The term head neck cancer refers to biologically similar cancers originating from the upper aerodigestive tract, including lip, oral cavity, nasal paranasal sinuses, pharynx larynx. About 90% are squamous carcinomas, mucosal lining (epithelium) these regions. Radiation therapy most common form treatment along with surgery chemotherapy. There different forms...
Abstract Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds DNA through CAATT-boxes and are involved in cellular differentiation stem cell maintenance. Here we show NFIC protein is significantly overexpressed 69% acute myeloid leukemia patients. Examination the functional consequences overexpression HSPCs showed this promoted monocytic differentiation. Single-cell RNA sequencing analysis further demonstrated overexpressing monocytes had increased expression...