A copper-mediated multi-component reaction was developed through isocyanide insertion into N-H bonds of less active secondary arylamines. This approach leads to an efficient synthesis unsymmetrical tetrasubstituted ureas in one pot.

Abstract An efficient method for the regioselective synthesis of pharmacologically relevant polysubstituted Δ 2 ‐isoxazolines is based on copper‐mediated direct transformation simple terminal alkynes and alkenes. The overall process involves formation four chemical bonds with inexpensive readily available copper nitrate trihydrate as a novel precursor nitrile oxides. reaction can be easily handled proceeds under mild conditions.

Six-membered ring oxygen and nitrogen heterocycles are formed stereoselectively by C–H insertion of donor/donor carbenes.

A range of benzene-fused carbocyclic molecules are accessed by the enantioselective C–H insertion rhodium donor/donor carbenes. The reaction is chemoselective for into carbon centers appended with an electron-donating heteroatom, including a ethers, free hydroxyl group, and nitrogen substituents, basic amines. DFT calculations support step-wise mechanism this process provide insight origin both stereoselectivity preference versus O–H insertion.

A range of benzene-fused carbocyclic molecules are accessed by the enantioselective C–H insertion rhodium donor/donor carbenes. The reaction is chemoselective for into carbon centers appended with an electron-donating heteroatom, including a ethers, free hydroxyl group, and nitrogen substituents, basic amines. DFT calculations support step-wise mechanism this process provide insight origin both stereoselectivity preference versus O–H insertion.

An efficient copper nitrate-mediated chemo- and regioselective annulation reaction of two different alkynes was developed to achieve polysubstituted isoxazoles.

An efficient copper nitrate mediated chloronitration reaction was developed for the direct synthesis of α-chloro-β-nitroolefins with high regio- and stereoselectivity from simple alkynes low toxic stannous chloride. This protocol provides a access to polysubstituted alkenes operational simplicity, good functional group tolerance, wide substrate scope. Various applications given products allowed straightforward assembly molecular complexity indicated them as promising valuable building blocks...

A direct nitration of vinylcyclopropanes is disclosed with Cu(NO3)2 and KI in a regio- stereoselective manner to afford nitroalkenes efficiently, where the cyclopropane skeleton was retained. The given method could be extended other vinylcycles as well biomolecule derivatives wide substrate scope, good functionality tolerance, efficient synthesis modularity. Further transformations illustrated obtained products versatile building blocks organic synthesis. proposed ionic pathway account for...

An efficient manganese(<sc>ii</sc>)-catalyzed oxidative radical cascade reaction was developed from vinyl isocyanides and hydrazines leading to the modular synthesis of multi-substituted isoquinolines, phenanthridines pyrrolo[1,2-<italic>a</italic>]quinoxalines.

A palladium-catalyzed multicomponent reaction of alkynes, carboxylic acids, and isocyanides has been developed with the assistance silver salt under mild conditions. Highly functionalized captodative olefins are synthesized efficiently by this method, which can find many applications as versatile synthons in organic synthesis.

We have previously shown that cardiac-directed expression of adenylycyclase type VI (AC(VI)) increases heart function in transgenic mice, and improves survival murine cardiomyopathy. However, a potential problem crossbreeding paradigms use lines with two constitutively active transgenes is results can be obfuscated by interactions between during growth development.To develop model could used subsequently to address this generic problem, mice tetracycline (tet)-regulated cardiac-specific...

An unprecedented copper-mediated anion transformation is reported, along with selective C═C double bond cleavage and dipolar cycloaddition reaction from simple alkenes inexpensive copper nitrate. Various transformations demonstrate the generality of this method. Further mechanistic investigation indicates a novel ionic pathway for alkene highlights coeffect iodide boric acid as additives on inhibition well-documented competitive nitration byproducts.

This account aims to describe our recent efforts on the synthesis and utilization of N-containing heterocycles, where transition metals participate in synthesis. A variety nitrogen sources, including amines, amides, hydrazones, pyrimidines, isocyanides, copper nitrate, have been disclosed for diverse bioactive pharmacologically interesting heterocycles under participation metals. The well-known such as amines were used construction indoles, isatins, quinolones. Dihydrophthalazines,...

Muscle atrophy is debilitating and can be induced by several stressors. Unfortunately, there are no effective pharmacological treatment until now. MicroRNA (miR)-29b an important target that we identified to commonly involved in multiple types of muscle atrophy. Although sequence-specific inhibition miR-29b has been developed, this study, report a novel small-molecule inhibitor targets hairpin precursor (pre-miR-29b) (Targapremir-29b-066 [TGP-29b-066]) considering both its three-dimensional...

Objective: The effects of chronic coronary occlusion on the capillarity left ventricular tissue in rat heart. Methods: heart was exposed through a left-sided thoracotomy ethylether-anesthetized and ventilated rats. artery occluded with thin suture thorax closed. Thirty days after surgery removed cross-sections were made for morphometric analyses. Results: cross-sectional area cardiomyocytes increased markedly subepi- subendocardia concomitant increase capillary to myocyte ratio. total...

Abstract A novel method was developed for the construction of biologically active poly‐substituted cinnolines from easily accessible hydrazones in good to excellent yields. simple copper catalyst could efficiently promote C−N bond formation through selective C−H functionalization and dehydrogenative amination. Furthermore, inert C−Heteroatom (O/F/N) bonds are susceptible cleavage high selectivity newly aerobic annulation, preference alternative bond, which is left intact. magnified image

A copper nitrate-mediated [2 + 2 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through C[double bond, length as m-dash]C bond cleavage. Copper nitrate is employed a promoter precursor nitrile oxides. The given approach features new mode from olefinic azlactones, unsaturated compounds with wide substrate scope, good functional group tolerance operational simplicity.

Substrates engineered to undergo a 1,4-C–H insertion yield benzocyclobutenes resulted in novel elimination reaction ortho -quinone dimethide ( o -QDM) products that Diels–Alder or hetero-Diels–Alder cycloadditions.

Comprehensive Summary An unprecedented copper nitrate‐mediated bond cleavage of alkynes was developed for the modular synthesis isoxazoles, where either C—S or C≡C triple cleaved selectively. Substituents attached to bonds could differentiate chemical and reaction pathways disparately. Various transformations products illustrate promising applications given protocols.

Abstract A regioselective copper nitrate‐mediated difunctionalization of alkenes has been developed for the rapid synthesis β‐bromonitrates, where nitrate is used as an ideal nitrooxy source first time and products will find many applications in organic versatile synthons. Different from general reports that acts nitro source, given protocol provides a direct access to functionalized nitrates, with operational simplicity, good functional group tolerance wide substrate scope. magnified image

An efficient copper-catalyzed regioselective olefinic C(sp²)–H bond cycloamination and acyloxylation was developed to give acyloxylated pyrazoles under mild conditions, which combines the formation of pyrazole skeleton installation an acyloxyl group in a single step.