A5018083376- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
- Radiation Therapy and Dosimetry
- Growth Hormone and Insulin-like Growth Factors
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Pituitary Gland Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Hormonal and reproductive studies
- Nuclear Physics and Applications
- Toxic Organic Pollutants Impact
- Thyroid Disorders and Treatments
- Anorectal Disease Treatments and Outcomes
- Radioactivity and Radon Measurements
- Diverticular Disease and Complications
- Prostate Cancer Treatment and Research
- Distributed and Parallel Computing Systems
- Colorectal and Anal Carcinomas
- Retinoids in leukemia and cellular processes
- Drug Transport and Resistance Mechanisms
- Radioactive contamination and transfer
- Thyroid Cancer Diagnosis and Treatment
- Interconnection Networks and Systems
- Parallel Computing and Optimization Techniques
- Helicobacter pylori-related gastroenterology studies
Hiroshima University
2016-2025
Okayama Rosai Hospital
2017
Kyoto University Research Reactor Institute
2014-2015
University of Occupational and Environmental Health Japan
2006-2015
Chiba Cancer Center
2015
Osaka University
1983-2008
The University of Tokyo
2001
Otsuka (Japan)
1998
Kanzaki (Japan)
1998
Takano Hospital
1990-1995
We find that stimulation of the protein kinase A (PKA) signaling pathway in MCF-7 human breast cancer cells changes agonist/antagonist activity tamoxifen and related antiestrogens; it activates or enhances their estrogen agonist reduces ability to antagonize effects estradiol (E2). In which contain high levels endogenous receptor (ER), antiestrogen trans-hydroxy-tamoxifen (TOT) fails stimulate transcription estrogen-responsive promoter-reporter constructs response element...
The most common objective function of task scheduling problems is makespan. However, on a computational grid, the 2nd optimal makespan may be much longer than because computing power grid varies over time. So, if performance measure makespan, there no approximation algorithm in general for onto grid. In contrast, recently authors proposed consumed by schedule as criterion and, criterion, gave (1+m(log/sub e/(m - 1) + 1)/n)-approximation RR n independent coarse-grained tasks with same length...
The prevalence of liver tumors throughout the world makes it imperative to seek chemopreventive agents. This tumor appears be hormone‐responsive and hormonal manipulations may therefore beneficial. On this basis, both sexes 12‐day‐old B6C3FJ mice were injected i.p. with diethylnitrosamine (DEN) at dose 2.5 μg/g body weight observed for 32 weeks (males) or 36 (females). In 100% male mice, an average diameter 2.72 mm multiplicity 60.8. Orchidectomy 6 age in these inhibited incidence, size 63%,...
Four kinds of cultured clonal cell line were established from estrogen-induced mammotropic pituitary tumor. These clones showed differences hormone secretion, morphology, and response to estrogen. One clone tentatively designated MtT/E, consisted spindle-shaped epithelial cells the strongest adhesion culture dish, but did not secrete any hormone. The second line, MtT/S, secreted only GH, very weak contact with proliferated almost anchorage independently. MtT/S mainly spherical formed...
In Sertoli cells of testis, androgen receptor-regulated gene transcription plays an indispensable role in maintaining spermatogenesis. Androgen receptor activity is modulated by a number coregulators which are associated with the receptor. Non-POU-domain-containing, octamer binding protein (NONO), member DBHS-containing proteins, complexes and functions as coactivator for Paraspeckle 1 alpha isoform (PSPC1, previously known PSP1) Splicing factor, proline- glutamine-rich (SFPQ, PSF), other...
The affinity for thyroid hormone receptor (TR) of polybromodiphenyl ethers (PBDEs) and hydroxylated PBDEs was examined. 4-Hydroxy-2,2',3,4',5-pentabromodiphenyl ether (4-OH-BDE-90) 3-hydroxy-2,2',4,4'-tetrabromodiphenyl (3-OH-BDE-47) markedly inhibited the binding triiodothyronine (1×10-10 M) to TR in concentration range 1×10-6-1×10-4 M. 2,3,4,5,6-Pentabromophenol (PBP) also showed an inhibitory effect at 1×10-5-1×10-4 However, 2,2',3,4,4',5'-hexabromodiphenyl (BDE-138), decabromodiphenyl...
Childhood radiation is a risk factor for thyroid cancer that became well known after the Chernobyl nuclear plant accident. Although these human cases have been extensively studied, mechanisms underlying childhood susceptibility to radiation-induced yet be explained. Our previous study showed neonatal X-irradiation resulted in long-term alterations mRNA expression of cancer-related marker genes, which may critical mechanism understanding higher sensitivity young patients. In this study, RNA...
To understand the biological effects of residual radioactivity after atomic bomb explosion in Hiroshima and Nagasaki, we previously investigated 56Mn, a major radioisotope. Our rat study demonstrated that inhalation exposure to 56MnO2 microparticles affected gene expression lungs, testes, liver, despite low radiation doses. Because 56Mn is β- γ-emitter, differential between γ-rays should be clarified. In this study, 31Si, β-emitter with radioactive half-life similar was used determine its...
Background/Objectives: Thyroid hormones are key regulators in hepatic metabolic pathways. Although they regulate various genes, only a few known to be under direct transcriptional regulation through thyroid hormone receptors. To better understand the roles of liver, it is critical identify hormone-responsive genes at cellular level. Methods: A cDNA microarray analysis was applied primary cultures rat cells treated with triiodothyronine (T3) 10−9 M for 24 h differentially expressed genes. The...
The most common objective function of task scheduling problems is makespan. However, on a computational grid, the 2nd optimal makespan may be much longer than because computing power grid varies over time. So, if performance measure makespan, there no approximation algorithm in general for onto grid. A novel criterion schedule proposed. proposed called total processor cycle consumption, which number instructions could compute until completion time schedule. Moreover, criterion, this gives...
We investigated the endocrine-disrupting actions of organophosphorus pesticide fenthion and related compounds influence metabolic transformation on activities these compounds. Fenthion acted as an antagonist androgenic activity dihydrotestosterone (10(-7)M) in concentration range 10(-6)-10(-4)M androgen-responsive element-luciferase reporter-responsive assay using NIH3T3 cells. The antiandrogenic was similar magnitude to that flutamide. also tested positive Hershberger castrated male rats....
To clarify the mechanism of tumorigenesis by kojic acid (KA), dose and time dependence iodine uptake in thyroid gland serum stimulating hormone (TSH) levels were investigated F344 rats fed a diet containing 2% KA. After 4 weeks, hyperplasia was apparent males, associated with decrease (125)I into to only 3% that controls. The triiodothyronine (T(3)) thyroxine (T(4)) dropped 0.36 ng/ml, 1.7 micrograms/dl from initial values 0.61 4.0 TSH increased seven times 15 ng/ml. In females, effects on...
Although ER beta is known to be expressed at high levels in the rat prostate gland, its regulation not well understood. Here we examined mRNA expression and effects of testosterone administration male rats 1, 4 9 weeks age who were castrated and/or treated with for a week, then sacrificed. alpha was major type 2 week-old animals while dominant apparent older groups. Interestingly diminished increased group, reversed this effect. A time-course study indicated that induction within hr...
The amino acid sequence of Thermoplasma acidophilum was determined by various conventional techniques. It is composed 142 residues including 9 cysteines. One the two cysteine clusters shows exactly same distribution as clostridial ferredoxins, but other a unique distribution. Comparison archaebacterial ferredoxins suggests multiple origins.