A5085834125- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Polyomavirus and related diseases
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
German Cancer Research Center
2020-2023
Heidelberg University
2020-2023
Lund University
2021
Maastricht University
2018
Abstract Background Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools predict both drug resistance and possible combination approaches overcome it are lacking. This unmet need mainly due the heterogeneity underlying mechanisms involved development itself. Methods To study complexity of selective estrogen receptor degrader (SERD) fulvestrant, we performed comprehensive biomarker analyses using several vitro models that recapitulate...
Merkel cell carcinoma (MCC) is a highly aggressive non-melanoma skin cancer of the elderly which associated with polyomavirus (MCPyV). MCC reveals trilinear differentiation characterized by neuroendocrine, epithelial and pre/pro B-cell lymphocytic gene expression disguising cellular origin MCC. Here we investigated neuroendocrine key regulators RE1 silencing transcription factor (REST), neurogenic 1 (NeuroD1) Achaete-scute homolog (ASCL1) in All MCCs were devoid REST positive for NeuroD1...
Breast cancer is one of the leading causes death for women worldwide. Patients whose tumors express Estrogen Receptor α account around 70% cases and are mostly treated with targeted endocrine therapy. However, depending on degree severity disease at diagnosis, 10 to 40% these eventually relapse due resistance development. Even though recent novel approaches as combination CDK4/6 inhibitors increased overall survival relapsing patients, this remains relatively short there a urgent need find...
Abstract Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated evolution and mechanistic in clonal populations cell models for estrogen receptor positive breast cancer. To this end, established barcoded luminal cancer rendered them resistant to commonly applied first line endocrine By isolating single clones from pools characterizing replicates individual observed inter- (between lines) intra-tumor different same line) heterogeneity....
Abstract Intratumoral heterogeneity drastically impacts the success or failure of anti-cancer therapies. Here, we investigated evolution and mechanistic in clonal populations cell models for estrogen receptor positive breast cancer. To this end, established barcoded luminal cancer rendered them resistant to commonly applied first line endocrine By deconvoluting complex pools characterizing replicates individual clones observed inter- (between lines) intra-tumor different from same line)...