A5091848974- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Planarian Biology and Electrostimulation
- Biocrusts and Microbial Ecology
- Insect and Arachnid Ecology and Behavior
- Mathematical Biology Tumor Growth
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Plant and animal studies
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Ecosystem dynamics and resilience
- Phagocytosis and Immune Regulation
- Covalent Organic Framework Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Cells and Metastasis
- Luminescence and Fluorescent Materials
- Plant and Biological Electrophysiology Studies
- Insect and Pesticide Research
Indian Institute of Science Bangalore
2023-2025
University of Bristol
2019-2022
Max Planck Institute for Medical Research
2016-2021
Heidelberg University
2016
Max Planck Institute for Intelligent Systems
2016
Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier cargo is specifically tailored on molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy drug in cancer cells nanocarrier delivery mediated COF.
Regulating the emergence of leaders is a central aspect collective cell migration, but underlying mechanisms remain ambiguous. Here we show that selective leader cells at epithelial wound-margin depends on dynamics follower and spatially limited by length-scale force transduction. Owing to dynamic heterogeneity monolayer, behind prospective manifest locally increased traction monolayer stresses much before these display any phenotypic traits. Followers, in turn, pull future elect them their...
We monitored metabolite secretion near living cells using a plasmonic nanosensor. The nanosensor created from borosilicate nanopipettes analogous to the patch clamp was decorated with Au nanoparticles and served as surface-enhanced Raman scattering (SERS) substrate addressable location. With this nanosensor, we acquired SERS locally Madin-Darby canine kidney (MDCKII) epithelial cells, detected multiple metabolites, such pyruvate, lactate, ATP, urea simultaneously. These nanosensors were...
Epithelial cells migrate across wounds to repair injured tissue. Leader at the front of migrating sheets often drive this process. However, it is unclear how leaders emerge from an apparently homogeneous epithelial cell population. We characterized emerging monolayers in culture and found that they activated stress sensor p53, which was sufficient initiate leader behavior. p53 cycle inhibitor p21 WAF1/CIP1 , turn induced behavior through inhibition cyclin-dependent kinase activity. also...
Why does the same oncogenic mutation drive tumor formation in some tissues but not others? While cancer driver mutations are well documented, their tissue specific effects remain largely attributed to genetic factors, leaving biophysical aspects underexplored. Here, we demonstrate that mechanical interactions, specifically interfacial tension between newly transformed and wildtype epithelial cells critical determining survival growth of HRasV12 mutants human mammary bronchial epithelia,...
Cells of epithelial tissue proliferate and pack together to attain an eventual density homeostasis. As the cell increases, spatial distribution velocity force show striking similarity dynamic heterogeneity observed elsewhere in dense granular matter. While physical nature this is somewhat known monolayer, its biological relevance precise connection remain elusive. Relevantly, we had demonstrated how large-scale monolayer stress field bulk could critically influence emergence leader cells at...
How individuals in a group lead to collective behavior is fundamental question across biological systems, from cellular animal groups, human organizations. Recent technological advancements have enabled an unprecedented increase our ability collect, quantify, and analyze how individual responses behavior. However, despite wealth of data demonstrating that exists scales, it difficult make general statements apply different systems. In this perspective, we present cohesive framework for...
Abstract Biological systems across various length and time scales are noisy, including tissues. Why biological tissues inherently chaotic? Does heterogeneity play a role in determining the physiology pathology of tissues? How do physical biochemical crosstalk to dictate tissue function? In this review, we begin with brief primer on Then, take examples from recent literature indicating functional relevance discuss impact function pathology. We specific studies epithelial potential inherent...
Collective migration is a central event involving coordinated movement of several individuals. One the critical events during collective emergence leading individuals, who provide directional guidance for group movement. While on move, animals select their leaders by decision making process, which require active participation followers. On contrary, prevalent view cell migration, especially in context epithelial cells wound healing, assumes hierarchical leader-follower organization and...
The study of collective behavior asks how individual actions combine to produce a group response. Research questions encompassing self-organization, motion, and decision-making apply systems ranging from cellular animal groups human organizations. Recently, technological advancements have enabled an unprecedented increase in our ability measure, quantify, analyze behavior. However, despite similar inquires the wealth data available, it is difficult make general statements about principles...
Biological systems across various length and time scales are noisy, including tissues. Why biological tissues inherently chaotic? Does heterogeneity play a role in determining the physiology pathology of tissues? How do physical biochemical crosstalk to dictate tissue function? In this review, we begin with brief primer on Then, take examples from recent literature indicating functional relevance discuss impact function pathology. We specific studies epithelial potential inherent tumorigenesis.