Widespread hyperalgesia has been found in patients with painful hip osteoarthritis (OA) which can be normalized after total arthroplasty (THA) if have no residual postoperative pain. This study characterized the preoperative somatosensory profiles and provided possible interpretation of underlying pain mechanisms that might influence development Forty OA unilateral were assessed before 6 weeks post-THA compared 40 asymptomatic control subjects. Hip intensity at rest while walking was on a...

Objective. Although severe knee osteoarthritis with refractory pain is commonly treated surgically, this often not an option for patients poor health status or unwillingness to undergo major surgery. We examined the efficacy of radiofrequency application sensory nerves as a novel alternative treatment pain. Methods. This study was open-label, nonrandomized, and controlled study. Patients complaining anteromedial associated radiological (moderate severe) were included. They assigned one two...

Abstract Background Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The purpose of this study was to clarify the role ASIC3 in rat model osteoarthritis (OA) which is considered degenerative rather than an inflammatory disease. Methods We induced OA via intra-articular mono-iodoacetate (MIA) injection, evaluated pain-related behaviors including weight bearing measured with...

The use of conditioning pain modulation (CPM) is hampered by poor reproducibility and lack user-independent paradigms. This study refined the CPM paradigm applying cuff algometry.In 20 subjects, effect with stimulation on arm was investigated test stimuli contralateral leg before in parallel different conditionings (10, 30, 60 kPa/60 s; kPa/10 s). As stimulus, another inflated (1 kPa/s) until subjects detected tolerance threshold (PTT) during which detection (PDT) pressure at a intensity 6...

This study investigates whether infrapatellar fat pad (IPFP) elasticity is associated with anterior knee pain in patients osteoarthritis (KOA). The IPFP of 97 KOA (Kellgren and Lawrence [KL] grades the femorotibial patellofemoral joints ≥ 2 ≤ 2, respectively), aged 46-86 years, was evaluated via shear wave speed using ultrasound elastography. were divided into two groups according to presence or absence pain. Univariate analyses used compare patient age, sex, KL grade, magnetic resonance...

Abstract Background The subchondral bone of the distal femur is a source pain caused by osteoarthritis ( OA ) or spontaneous osteonecrosis knee. However, nociceptive phenotype dorsal root ganglia DRG neurons innervating in rat knee joints has not been clarified. Methods Retrograde labelling was used to identify afferents and joint rats. markers [calcitonin gene‐related peptide CGRP ), tyrosine receptor kinase A TrkA neurofilament 200 NF 200) isolectin B 4 IB 4)], segmental distribution soma...

Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip model was established in which referrals hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, induced by hypertonic saline injection into the gluteus medius tendon (GMT), adductor longus (ALT), or muscle (GMM). Isotonic injected contralaterally as control. Pain intensity assessed on a visual analogue scale...

Abstract This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis (OP) on pathology knee osteoarthritis (OA) in a rat meniscectomized model, particularly focusing subchondral bone changes and pain behaviour. Rats were divided into four groups, sham, OP, OA, OP plus assessed for histology, osteoclast activity, microstructure, pain-related with OA had significantly increased calcified cartilage damage scores, densities osteoclasts weight-bearing area, more...

Abstract Background Severe knee pain associated with osteoarthritis (OA) is one of the most common and troublesome symptoms in elderly. Recently, local bone denervation by MR-guided focused ultrasound (MRgFUS) has been demonstrated as a promising tool for palliation metastases. The purpose this study was to develop novel treatment OA using MRgFUS, validate its safety efficacy. Methods Eight patients medial eligible total arthroplasty were included. sonication treatments applied surface just...

Abstract Background Intra‐articular hyaluronic acid ( HA ) injection, known as viscosupplementation, is a widely used therapy for pain relief in knee osteoarthritis OA ). Long‐term clinical efficacy of has been reported spite relatively short residence time. Herein, we evaluated our hypothesis that intra‐articular injection could reduce the ‐associated changes joint afferents. Methods was induced by mono‐iodoacetate rats. Animals + group were given three weekly injections. Pain‐related...

Altered pain facilitatory and inhibitory mechanisms have been recognized as an important manifestation in patients with chronic pain, quantitative sensory testing (QST) can act a proxy for this process. We recently developed simple bedside QST tool kit (QuantiPain) more clinical use. The purpose of study was to investigate its test-retest reliability evaluate validity compared the laboratory-based protocols knee osteoarthritis (OA).QuantiPain consists 3 items: "pressure algometer" (for...

Local bone denervation by magnetic resonance-guided focused ultrasound (MRgFUS) is a promising tool for alleviation of pain in patients with painful metastasis (BM). Considering the underlying mechanism alleviation, MRgFUS might be effective various and joint diseases associated local tenderness. This study was conducted to clarify therapeutic effect that are Ten BM, 11 lumbar facet osteoarthritis (L-OA), 19 knee (K-OA) were included. treatment applied surface real-time temperature...

To elucidate the prevalence and risk factors of chronic postsurgical pain (CPSP) after primary total knee arthroplasty (TKA) in Japanese population.Consecutive patients undergoing TKA a tertiary hospital (211 knees) were assessed. CPSP was defined as moderate to severe (VAS >30 mm), either at rest or during walking, one year surgery. Clinical radiographic data compared between non-CPSP groups multivariate logistic regression used identify predictors CPSP.The 8.8%. group showed significantly...

Nerve growth factor (NGF) and sensory nerves are key factors in established osteoarthritis (OA) knee pain. We investigated the time course of NGF expression nerve across early late stages OA progression rat knees.Knee was induced by medial meniscectomy rats. histopathology, expression, calcitonin gene-related peptide immunoreactive (CGRP-IR) were quantified pre-surgery post-surgery at weeks 1, 2, 4 6. Pain-related behavior evaluated using dynamic weight distribution mechanical sensitivity...

Although disease progression of osteoarthritis has been well documented, pain pathophysiology is largely unknown. This study was designed with two purposes: 1) to characterize patients knee predominantly originating from intra-articular structures and 2) describe the location pattern their pain.103 medial underwent an injection local anesthetics (joint block). At least 70% relief defined as positive for joint block, while less than 50% negative. Pain characteristics in block were evaluated...

The criterion of long-standing groin pain diagnoses in athletes usually relies on palpation and clinical tests. An experimental model was developed to examine the tests under standardized conditions. Pain induced by hypertonic saline injected into proximal adductor longus (AL) tendon or rectus femoris (RF) 15 healthy male participants. Isotonic contralaterally as a control. intensity assessed visual analog scale (VAS). Resisted hip adduction at three different angles trunk flexion were...

Purpose This study aims to clarify the chronological changes in functional cup position at a minimum follow-up of 10 years after total hip arthroplasty (THA), and identify risk factors influencing significant difference during postoperative period. Methods We evaluated THA 58 patients with unilateral osteoarthritis. Radiographic was measured on anteroposterior pelvic radiographs patient supine position, whereas recorded standing position. Radiographs were obtained before, 3 weeks after,...