A5101569619- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Animal Behavior and Welfare Studies
- Sirtuins and Resveratrol in Medicine
- Muscle Physiology and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Effects of Environmental Stressors on Livestock
- Biochemical Analysis and Sensing Techniques
- Meat and Animal Product Quality
- Bee Products Chemical Analysis
- Reproductive Physiology in Livestock
- Birth, Development, and Health
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Genetic and phenotypic traits in livestock
- Folate and B Vitamins Research
- Polyamine Metabolism and Applications
- Scientific Research and Discoveries
- Wildlife Ecology and Conservation
- Probiotics and Fermented Foods
- Chemical Synthesis and Analysis
- Magnetic and Electromagnetic Effects
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
Huazhong Agricultural University
2016-2025
Center of Hubei Cooperative Innovation for Emissions Trading System
2015-2020
University of Illinois Urbana-Champaign
2018
Urbana University
2018
Kerala Veterinary and Animal Sciences University
2015
A complex and highly orchestrated gene expression program chiefly establishes the properties that define adipocyte phenotype, in which vast majority of factors are involved transcriptional regulation. However, mechanisms by post-transcriptional modulation poorly understood. Here, we showed zinc finger protein (Zfp217) couples transcription to m6A mRNA modification facilitate adipogenesis. Zfp217 modulates methylation activating demethylase FTO. Consistently, depletion compromises adipogenic...
This experiment was conducted to evaluate the effects of quercetin supplementation on intestinal integrity, reactive oxygen species (ROS) levels and inflammation in pigs under transport stress. A total 170 finishing were randomly assigned into two groups. Animals control group consumed a basal diet, while those treatment same diet supplemented with 25 mg per kg feed. After 4-week period, transported for 5 hr. The quercetin-supplemented showed decreased serum endotoxin (P<0.05), increased...
Sirtuin 1 (SIRT1) regulates adipocyte and osteoblast differentiation.However, the underlying mechanism should be investigated.This study revealed that SIRT1 acts as a crucial repressor of adipogenesis.RNA-interference-mediated knockdown or genetic ablation enhances adipogenic potential, whereas overexpression inhibits adipogenesis in mesenchymal stem cells (MSCs).SIRT1 also deacetylates histones sFRP1, sFRP2, Dact1 promoters; mRNA expression Dact1; activates Wnt signaling pathways;...
Abstract It is well known that obesity‐induced white adipose tissue inflammation an important reason for insulin‐resistance and type 2 diabetes mellitus. Sirtuin‐1 (SIRT1) regulator of inflammtion response pathways in tissue. Here, we found miR‐221 negatively regulated SIRT1 during HFD‐induced obesity. MiR‐221 a putative oncogene which has been overexpressed number human tumors. Recently, it also was increased obese may be involved insulin‐resistance. However the specific mechanism remains...
This study investigated the influence of sow backfat thickness at 109 d gestation on and piglet performance. Data from 846 farrowing multiparous Yorkshire sows with parity 3 to 5 were collected a pig breeding farm. Sows divided into six groups based (≤16, 17-18, 19-20, 21-22, 23-24, ≥25 mm) gestation. The evaluation reproductive performance included litter size, weight birth weaning 21 d, placenta parturition, placental efficiency, daily feed intake lactation. Parameters related plasma...
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages differentiation. Kruppel-like (KLFs) as family zinc-finger play diverse roles during cell differentiation and development in mammals.In the present study, we showed that KLF13 acts key regulator regulating porcine adipocyte The expression was markedly up-regulated early stage differentiation, which followed PPARγ. Porcine significantly attenuated addition siRNA against KLF13, whereas...
Gelatin hydrolysate was reported to contain large amounts of biologically active peptides with excellent antioxidant properties. However, its inducement response within cells and the underlying molecular mechanism are far from clear. Here, gelatin Nile tilapia skin hydrolyzed by ginger protease produce hydrolysate, three fish fractions (FSGHFs) were obtained ultrafiltration. Fractionation increased free radical scavenging capacity FSGHFs, particularly FSGHF3, which showed lowest weight...
The directed differentiation of mesenchymal stem cells (MSCs) is tightly controlled by a complex network. Wnt signaling pathways have an important function in controlling the fate MSCs. However, mechanism through which Wnt/β-catenin regulated MSCs remains unknown. SIRT1 plays role regulation differentiation.This study aimed to determine effect sirtuin 1 (SIRT1) on adipogenesis and myogenic C3H10T1/2 cells. First, MSC commitment model was established using 5-azacytidine. Using model, were...
The mammalian target of rapamycin complex 1 (mTORC1) integrates amino acid (AA) availability to support protein synthesis and cell growth. Taste receptor type member (T1R) is a G protein-coupled that functions as direct sensor extracellular AA regulate mTORC1 through Ca2+ stimulation signal–regulated kinases 2 (ERK1/2) activation. However, the roles specific AAs in T1R1/T1R3-regulated are poorly defined. In this study, T1R1 T1R3 subunits were expressed C2C12 myotubes, l-AA sensing was...
Dietary n -3 PUFA have been demonstrated to promote muscle growth in growing animals. In the present study, fractional protein synthesis rates (FSR) skeletal of pigs fed a DHA-enriched (DE) diet (DE treatment) or soyabean oil (SO) (SO were evaluated and feed-deprived states. Feeding-induced increases FSR, as well activation mammalian target rapamycin kinase B, higher DE treatment indicated by positive interaction between feeding. state, eIF4E-binding 1 on was than that SO ( P < 0·05)....
// Jie Peng 1 , Yinghui Wu Zhao Deng Yuanfei Zhou Tongxing Song Yang Xiaming Zhang Tao Xu Mao Xia Anle Cai Zuhong Liu and Jian 1, 2 Department of Animal Nutrition Feed Science, College Science Technology, Huazhong Agricultural University, Wuhan 430070, P. R. China The Cooperative Innovation Center for Sustainable Pig Production, Correspondence to: Peng, email: pengjian@mail.hzau.edu.cn Keywords: miR-377, SIRT1, obesity, inflammation, insulin-resistance Received: January 24,...
Isosteviol, a naturally occurring tetracyclic triterpenoid, is versatile compound with various biological activities. Activation of the inert C‐H bonds isosteviol can increase its potential activity, but this activation remains challenging in traditional organic synthesis. Cytochrome P450 BM3 typically used as tool enzyme to accomplish goal. In study, we similarity analysis, molecular docking and site‐specific mutation successfully achieve catalytic hydroxylation 12β‐OH isosteviol. Compared...
To understand whether soluble fiber (SF) with high water-binding capacity (WBC), swelling (SC) and fermentability reduces food intake it does so by promoting satiety or satiation both, we investigated the effects of different SFs these properties on in rats. Thirty-two male Sprague-Dawley rats were randomized to four equal groups fed control diet containing 2% konjac flour (KF), pregelatinized waxy maize starch (PWMS) plus guar gum (PG), PWMS xanthan (PX) for three weeks, measured values SF,...
PPARγ and Wnt signaling are central positive negative regulators of adipogenesis, respectively. Here we identified that, eicosapentaenoic acid (EPA) could effectively induce the transdifferentiation myoblasts into adipocytes through modulation both expression signaling. During early stage transdifferentiation, EPA activates PPARδ PPARγ1, which in turn targets β-catenin to degradation down-regulates Wnt/β-catenin signaling, such that myogenic fate be switched adipogenesis. In addition,...
Over the past years, antibiotic growth promoter had been restricted in animal husbandry production many countries because of antimicrobial resistance and foodborne residues. However, problems poor intestinal health low efficiency piglets have not solved completely an antibiotic-free diet, it is urgent to explore alternatives promoters.Here, a total 532 weaned pigs were assigned one 4 treatments, amino acid (AA) level diet (d 1 d 14 1.35%, 15 42 1.25%) (Low AA), AA supplementation with...