A5047106954- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Synthesis and properties of polymers
- Maternal Mental Health During Pregnancy and Postpartum
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Parvovirus B19 Infection Studies
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Estrogen and related hormone effects
- Epoxy Resin Curing Processes
- Pharmacological Effects and Toxicity Studies
- Gestational Diabetes Research and Management
- Blood groups and transfusion
- Hepatitis C virus research
- COVID-19 and healthcare impacts
Ministry of AYUSH
2024
Stanford University
2024
Southern Medical University
2024
Ruijin Hospital
2024
Nanfang Hospital
2024
Huashan Hospital
2024
Fudan University
2024
Ministry of Education
2024
University of Arizona
2020-2023
Roche (United Kingdom)
2022
BackgroundXalnesiran, a small interfering RNA molecule that targets conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an immunomodulator, in patients chronic infection.MethodsWe conducted phase 2, multicenter, randomized, controlled, adaptive, open-label platform trial included evaluation 48 weeks treatment xalnesiran at dose 100 mg (group 1), 200 2), plus 150 ruzotolimod 3), 180 μg pegylated interferon alfa-2a...
<b>Objective</b> The objective of this study was to determine the maternal and fetal pharmacokinetic (PK) profiles acetaminophen after administration a therapeutic oral dose. <b>Study Design</b> After obtaining Institutional Review Board approval their written informed consent, pregnant women were given single dose (1,000 mg) upon admission for scheduled cesarean delivery. Maternal venous blood cord obtained at time delivery levels measured using gas chromatography-mass spectroscopy. PK...
Romiplostim, a thrombopoietin mimetic, is novel therapeutic option for patients with chronic immune thrombocytopenic purpura. We report on the effects of romiplostim use throughout pregnancy.A 28-year-old primigravid woman purpura initiated planned pregnancy romiplostim. The second and third trimesters were marked by cyclic pattern thrombocytopenia requiring supplemental corticosteroids or intravenous immunoglobulin resultant thrombocytosis. Increased doses daily stabilized platelet count...
Twin pregnancies are associated with an increased risk of spontaneous preterm birth. Our objective was to compare the performance uterocervical angle cervical length as predictors birth in this population.We conducted a retrospective cohort study twin gestations at single center from May 2008 2016 who received transvaginal ultrasound for evaluation cervix between 16 0/7 and 23 weeks. The primary outcome prediction <28 <32 weeks by length.Among 259 women gestation, mean gestational age 34.83...
ABSTRACT Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed hippocampus within hours experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted PAFr −/− mice but partially mitigated lacking recognition proteins TLR2 and Nod2 overexpressing interleukin-10 (IL-10) macrophages. Thus, drives through IL-10-repressible inflammatory events. Treatment...
We provide some new insights into the kinetics and mechanism of sol−gel transition as it pertains to regenerated silk fibroin, which is principle structural protein silkworm fiber. Silk fibroin was dissolved in lithium bromide dialyzed against deionized water prepare a solution. This solution found be unstable at lower pH transformed colloidal gel. The were investigated using rheology light scattering. show that gelation proceeds two steps. In first step, weak gel formed almost immediately...
In recent years, medical expulsive therapy has been used in the management of distal ureteric stones as a supplement to conservative treatment. Therefore, we conducted prospective randomized study evaluate possible role tadalafil individually comparison with proven tamsulosin stone expulsion. The aim this is compare safety and efficacy phosphodiesterase-5 inhibitor (tadalafil) an α-1 blocker (tamsulosin) for calculi.Between August 2014 October 2015, 207 patients who presented size 5-10 mm...
Morbidity related to hypertrophic scars and contractures which are well known sequel after burns remains high in fact has increased as more severely burned patients surviving. This study was undertaken order assess the varied clinical presentation, precipitating factors, preventive measures, treatment modalities of neck evaluate results surgical procedures.This hospital based conducted on admitted our institution with proven cases Post burn contracture from 1st August 2009 31st July 2011....
Introduction COVID-19 created a global need for healthcare worker (HCW) training. Initially, mass trainings focused on public health workers and physicians working in intensive care units. However, resource-constrained settings, nurses general practitioners provide most patient care, typically lacking the training equipment to manage critically ill patients. We developed massive open online course (MOOC) HCWs settings aimed at bedside providers caring describe development, implementation...
International Journal of Medicine and Public Health,2011,1,4,28-38.DOI:10.5530/ijmedph.4.2011.7Published:Oct/2011Type:Original ArticleClinical Profile outcome envenomous snake-bite at tertiary care centre in western MaharashtraVirendra C. patil, Harsha V. Patil, Avinash Vaibhav Agrawal Virendra Patil1, Patil2, Agrawal1 1Department , Krishna Institute Medical Sciences University, Dhebewadi Road, Karad, Satara District, Maharashtra – 415 110, India. 2Department Microbiology...
New phthalide-containing bisphenols, phenolphthalein-N-(3-methylanilide) (3-PMA), and phenolphthalein-N-(4-methylanilide) (4-PMA), were synthesized from phenolphthalein m- p-toluidines. These bisphenols polycondensed with terephthaloyl chloride (TPC) using an interfacial or solution polymerization technique to yield new polyesters. Copolymers also obtained by utilizing different molar proportion of (PPH) 3-PMA 4-PMA TPC. The polymers prepared in 93–99% yields showed reduced viscosities the...
Purpose: The purpose of this study is to evaluate the incidence maternal cell contamination (MCC) in first few milliliters amniotic fluid withdrawn during amniocentesis.Methods: A prospective observational was performed. initial 2–3 ml amniocentesis divided into direct analysis (uncultured) and cultured samples. matching buccal swab obtained for MCC testing. determined by short-tandem repeat analysis. primary outcome measurement clinically significant (MCC >5%). Secondary outcomes included...
Progesterone is critical for maintaining pregnancy and onset of labor. We evaluated CYP450-mediated progesterone meta-bolism, specifically the contribution CYP3A isoforms.In vitro metabolism was characterized in human liver microsomes (HLMs) with without selective cytochrome P450 inhibitors recombinant CYP3A4, CYP3A5, CYP3A7. 6β-hydroxyprogesterone (6β-OHP) 16α-hydroxyprogesterone (16α-OHP) metabolites were quantified by HPLC/UV fit to Michaelis-Menten equation determine Km Vmax. The effect...