A5085883046- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Cancer Genomics and Diagnostics
- Parvovirus B19 Infection Studies
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Congenital Anomalies and Fetal Surgery
- Preterm Birth and Chorioamnionitis
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Renal and related cancers
- Ectopic Pregnancy Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- COVID-19 Impact on Reproduction
- Hemoglobinopathies and Related Disorders
- Maternal and Perinatal Health Interventions
- Neonatal and Maternal Infections
- Erythrocyte Function and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- Pregnancy and Medication Impact
- Kawasaki Disease and Coronary Complications
University of Washington
2018-2025
Brotman Baty Institute
2025
Seattle University
2018-2024
Community Link
2024
Society for Maternal-Fetal Medicine
2022
University of Washington Medical Center
2015-2021
Sri Siddhartha Medical College
2021
University of Pittsburgh
2014-2015
Magee-Womens Hospital
2014
Ottawa Hospital Research Institute
2006
The mechanisms underlying dopamine neuron loss in Parkinson's disease (PD) are not clearly defined. Here, we delineate a pathway by which dopaminergic induced 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) is controlled vivo . We reported previously that calpains play central required role after MPTP treatment. provide evidence the downstream effector of through cyclin-dependent kinase 5 (cdk5)-mediated modulation transcription factor myocyte enhancer 2 (MEF2). show MPTP-induced...
Preeclampsia is associated with diastolic dysfunction, peripartum cardiomyopathy, and both pre-existing subsequent maternal cardiovascular disease. Gene mutations causing idiopathic cardiomyopathy were recently implicated in cardiomyopathy. We sought to determine whether gene are also a contributory factor preeclampsia.Subjects participants The Registry Biobank. After providing informed consent, subjects history of preeclampsia completed detailed questionnaire provided medical records for...
Preeclampsia is characterized by placental dysfunction and results in significant morbidity, but reliable early prediction remains challenging. We investigated whether clinically obtained prenatal cell-free DNA (cfDNA) screening (PDNAS) using whole-genome sequencing (WGS) data can be leveraged to predict preeclampsia risk pregnancy (≤16 weeks). Using 1,854 routinely collected clinical PDNAS samples (median, 12.1 weeks) with low-coverage (0.5×) WGS data, we developed a framework quantify...
Background: Multivalent conjugate Group B streptococcus (GBS) vaccines are in development for use pregnancy. We aimed to understand perceptions of a novel GBS vaccine among pregnant and lactating persons following the COVID experience. Methods: As part an ongoing survey-based prospective cohort study, we conducted follow-up survey with questions about knowledge acceptability clinical trial participation vaccine. Participants this Institutional Review Board-exempt study completed surveys via...
<b>Objective</b> This study aims to identify risk factors for cesarean delivery (CD) surgical site infection (SSI). <b>Study Design</b> Retrospective analysis of 2,739 CDs performed at the University Pittsburgh in 2011. CD SSIs were defined using National Healthcare Safety Network (NHSN) criteria. Chi-square test and <i>t</i>-test used bivariate analyses multivariate logistic regression was SSI factors. <b>Results</b> Of CDs, 178 (6.5%) complicated by SSI. Patients with a more likely have...
Preterm premature rupture of membranes (PPROM) is a major contributor to overall preterm birth (PTB) rates. A short interpregnancy interval (IPI) well-known risk factor for PTB. It unknown if IPI specifically affects the developing PPROM in subsequent pregnancy. We sought determine association between and pregnancy.A retrospective cohort study using Missouri certificate database singleton births from 2003 2013 was conducted. (delivery prior pregnancy conception index pregnancy) defined as ≤6...
Abstract Human cytomegalovirus (CMV) infections comprise a leading cause of newborn impairments worldwide and are pervasive concerns among the immunocompromised. Quantification CMV viral loads is increasingly used to guide definitions disease but standardization quantitation remains problematic, mostly due differences in qPCR amplicon sizes between clinical laboratories. Here, we plasma cfDNA sequencing data from 2,208 samples sent for non-invasive prenatal aneuploidy screening detect...
Uterine leiomyomas may affect the performance of cell-free DNA (cfDNA)–based noninvasive prenatal testing (NIPT). We conducted a retrospective cohort study pregnant individuals with and without undergoing first-trimester cfDNA-based NIPT. Characteristics NIPT in patients (n=122) were compared those (n=937). Mean fetal fraction was lower (10.0% vs 11.5%; P =.001); however, rate indeterminate results different only obesity (body mass index [BMI] than 30) (5.3% 1.5%; =0.03). Total cfDNA...
Preeclampsia (PE) is associated with an increased risk of maternal cardiovascular disease (CVD), however, it unclear whether this due to shared underlying physiology or changes which occur during the process. Fetal microchimerism (FMc) within circulation can durably persist decades after pregnancy, known at greater frequency in PE, and potentially affect local systemic immune programming, thus cellular FMc may provide a mechanism for long-term health outcomes PE.
Objectives To gain insight into the patient journey through a pre-eclampsia-complicated pregnancy. Design Cross-sectional registry study. Setting Online initiated by Preeclampsia Foundation. Participants Women with history of pre-eclampsia enrolled in The Registry (TPR). Primary and secondary outcome measures Retrospective patient-reported experience concerning awareness pre-eclampsia, timing type information on received, involvement decision making regarding medical care, mental/emotional...
Objective To compare fetal microchimerism ( FM c) in pregnancies with uncomplicated vaginal delivery VD ) versus caesarean CD ). Design Prospective cohort study. Setting University of Washington and Fred Hutchinson Cancer Research Center, USA . Population Women delivering singleton without pertinent antenatal complications deliveries n = 36). Methods We collected maternal predelivery, postdelivery umbilical cord blood for each mother–baby pair. Following genotyping, c was measured...
Reasons for first trimester noninvasive prenatal screening (NIPS) test failure in obese women remain elusive. As dilution from maternal sources may be explanatory, we determined the relationship between obesity, fetal fraction (FF), and total cell-free DNA (cfDNA) using our NIPS platform.We assessed differences (≤14 weeks) FF, indeterminate rate, cfDNA (n = 518) normal-weight 237) after exclusion of confounders (anticoagulation, autoimmunity, aneuploidy) controlling covariates.Fetal was...
Background Placental derived cell-free DNA (cfDNA), widely utilized for prenatal screening, may serve as a biomarker preeclampsia. To determine whether cfDNA parameters are altered in preeclampsia, we conducted case-control study using prospectively collected maternal plasma (n=20 n=22 normal) our in-house validated screening assay. Methods and Results Isolated was quantified, sequenced Illumina NextSeq 500, the placental-derived fraction determined. Clinical test characteristics were...
Incorporation of the patient voice is urgently needed in a broad array health care settings, but it particularly lacking obstetrical literature. Systematically derived information about patients' experience with hypertensive disorders pregnancy (HDP), most notably preeclampsia, necessary to improve patient-provider communication and ultimately inform patient-centered research. We sought examine needs experiences individuals pregnancies complicated by disorders.We conducted qualitative...
(Abstracted from Am J Obstet Gynecol 2023;229:435.e1–435.e7 Cell-free DNA (cfDNA) screening is an effective way to identify trisomy 21 in singleton pregnancies and has been shown have both a high detection rate low false-positive rate. For twin pregnancies, however, there are challenges relating fetal fraction the ability obtain distinguish DNA.
Placentation presents immune conflict between mother and fetus, yet in normal pregnancy maternal immunity against infection is maintained without expense to fetal tolerance. This believed result from adaptations at the maternal-fetal interface (MFI) which affect T cell programming, but identities (i.e., memory subsets antigenic specificities) of cells signals that mediate fates functions MFI remain poorly understood. We found intact recruitment programs as well pro-inflammatory cytokine...