A5102951833- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Genetic Syndromes and Imprinting
- Rheumatoid Arthritis Research and Therapies
- Parvovirus B19 Infection Studies
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- BRCA gene mutations in cancer
- Urticaria and Related Conditions
- Ovarian cancer diagnosis and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and preeclampsia studies
- Immunodeficiency and Autoimmune Disorders
- Hepatitis C virus research
- Connective Tissue Growth Factor Research
- Renal and related cancers
- T-cell and B-cell Immunology
- Cervical Cancer and HPV Research
- Eosinophilic Disorders and Syndromes
- Liver Diseases and Immunity
- Cancer Risks and Factors
Fred Hutch Cancer Center
2013-2025
University of Washington
2013-2025
University of Copenhagen
2018
Clinical Research Management
2014-2017
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
1991-2017
Cancer Research Center
1991-2017
Patient Advocate Foundation
2017
Center for Rheumatology
2014
Seattle University
2006-2014
North Seattle College
1999-2002
Few studies have reported on interventions to alleviate financial toxicity in patients with cancer. We developed a navigation program collaboration our partners, Consumer Education and Training Services (CENTS) Patient Advocate Foundation (PAF), improve patient knowledge about treatment costs, provide counseling, help manage out-of-pocket expenses. conducted pilot study assess the feasibility impact of this program.Patients cancer received education course followed by monthly contact CENTS...
A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) been previously identified. The present study attempts to confirm these findings.We performed a second genome-wide screen 256 new multicase RA families recruited from across the United States by North American Rheumatoid Arthritis Consortium. Affected sibling pair analysis on data set was using SIBPAL. We subsequently combined our first and sets in an attempt enhance linkages larger sample...
Abstract Objective Microchimerism (Mc), originating from bidirectional fetal–maternal cell traffic during pregnancy, has recently been identified in healthy adults and patients with scleroderma (systemic sclerosis [SSc]). This study was undertaken to investigate the frequency quantitative levels of maternal Mc (MMc) women SSc. Methods HLA‐specific primers fluorogenic probes were used real‐time polymerase chain reaction assays detect quantify MMc by targeting noninherited, nonshared HLA...
Objective Exaggerated neutrophil activation and formation of extracellular traps ( NET s) are linked to inflammation autoimmunity, including rheumatoid arthritis RA ). However, whether s present in the circulation patients contribute disease progression has not been carefully addressed. We undertook this study assess markers plasma samples, investigating they add clinical value improving determination prognosis monitoring patients. Methods Markers (calprotectin) cell death were analyzed,...
We conducted a case-control study to determine whether job strain (or stress) during pregnancy resulted in an increased risk of preeclampsia. compared 110 nulliparous Caucasian and African-American women who had preeclampsia with 115 healthy controls. All subjects gave birth between 1984 1987 Chapel Hill, NC. Occupation was ascertained telephone interview. assigned each title score accordance the occupational database developed by Karasek. Overall, 54 (49%) control worked pregnancy, 14...
Abstract Fetal microchimerism (FMc) describes long-term persistence of small numbers fetal-derived allogeneic cells in the mother. Although FMc has been implicated as a mechanism autoimmune disease, it may confer beneficial effect with immune surveillance malignant cells. We hypothesized that imparts protective against breast cancer. Two observations provided rationale for study hypothesis. First, convey risk reduction recurrent malignancy hematopoietic cell transplantation. Second, reduced...
An RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) has been purified from phage-SP01-infected Bacillus subtilis that copies almost exclusively the heavy strand of native SP01 DNA, DNA which "middle" and "late" classes are copied in vivo. Hybridization-competition established this termed enzyme A, preferentially synthesizes middle vitro. Enzyme A contains beta',beta, alpha, two newly identified host polypeptides, variation (21,500 daltons) omega (11,000...
Abstract As part of a prospective case‐control study newly diagnosed rheumatoid arthritis (RA) in women, we identified all cases probable, definite, or classic RA 1987–1989 18–64‐year‐old women who were members health maintenance organization based the Seattle, Washington area. Using both 1958 and 1987 American Rheumatism Association criteria for diagnosis enrollment data from organization, calculated incidence by age diagnostic class. Rates increased steadily with age. The ranged 13.1 per...
BackgroundPrior pregnancy is known to protect against development of breast cancer. Recent studies have demonstrated that has the capacity establish small numbers immunologically active fetal-derived cells in mother, a phenomenon as fetal microchimerism (FMc). We asked whether presence FMc, routinely acquired during pregnancy, protective factor for cancer.Methodology/Principal FindingsDNA extracts from peripheral blood specimens were obtained population-based case-control study risk factors...
A mother's infection with placental malaria (PM) can affect her child's susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a small amount of maternal cells and DNA known as microchimerism (MMc), we hypothesized that PM increases MMc alters risk Plasmodium falciparum during infancy.In nested cohort from Muheza, Tanzania, evaluated presence level cord blood in offspring women without PM. maternal-specific polymorphism was identified for each maternal-infant...
Autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc) are characterized by a strong genetic susceptibility from the Human Leucocyte Antigen (HLA) locus. Additionally, disorders of epigenetic processes, in particular non-random X chromosome inactivation (XCI), have been reported many female-predominant autoimmune diseases. Here we test hypothesis that women with RA or SSc who strongly genetically predisposed less susceptible to XCI bias.Using methylation...