A5101895905- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Acute Ischemic Stroke Management
- Hepatitis C virus research
- Neuroscience and Neural Engineering
- Hepatitis B Virus Studies
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Spinal Cord Injury Research
- Liver Disease Diagnosis and Treatment
- Hand Gesture Recognition Systems
- Advanced Sensor and Energy Harvesting Materials
- Vagus Nerve Stimulation Research
- Functional Brain Connectivity Studies
- Action Observation and Synchronization
- Neurological disorders and treatments
- Ultrasound and Hyperthermia Applications
- Neural and Behavioral Psychology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Aerospace Center Hospital
2025
Peking University
2018-2025
Southern Medical University
2024
Nanfang Hospital
2024
Huashan Hospital
2024
Fudan University
2024
Ministry of Education
2024
University of Michigan–Ann Arbor
2024
Functional electrical stimulation (FES) is capable of activating muscles that are under-recruited in neurological diseases, such as stroke. Therefore, FES provides a promising technology for assisting upper-limb motor functions rehabilitation following However, the full benefits may be limited due to lack systematic approach formulate pattern stimulation. Our preliminary work demonstrated it feasible use muscle synergy guide generation patterns.In this paper, we present methodology...
BackgroundXalnesiran, a small interfering RNA molecule that targets conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an immunomodulator, in patients chronic infection.MethodsWe conducted phase 2, multicenter, randomized, controlled, adaptive, open-label platform trial included evaluation 48 weeks treatment xalnesiran at dose 100 mg (group 1), 200 2), plus 150 ruzotolimod 3), 180 μg pegylated interferon alfa-2a...
Abstract Background Non-invasive brain stimulation techniques have been shown in several studies to improve the motor recovery of affected upper-limbs stroke patients. This study aims investigate whether or not cathodal transcranial direct current (c-tDCS), combined with virtual reality (VR), is superior VR alone reducing impairment and improving upper limb function quality life Methods Forty patients who suffered ischemic between 2 weeks 12 months were recruited for this single-blind...
Transcranial focused ultrasound stimulation (tFUS) regulates neural activity in different brain regions humans and animals.However, the role of modulating promoting neurorehabilitation ischemic is largely unknown.In present study, we explored effect tFUS on neurological rehabilitation underlying mechanism.Adult male ICR mice (n=42) underwent transient middle cerebral artery occlusion.One week after ischemia, low frequency (0.5 MHz) was applied to stimulate hemisphere for 7 consecutive days...
The central nervous system (CNS) produces movements by activating specifically programmed muscle synergies that are also altered with injuries in the brain, such as stroke. In this study, we hypothesize there exists a positive correlation between task-specific synergy and motor functions at joint task levels patients following purpose here is to define evaluate neurophysiological metrics based on for assessing patients. A patient group of ten subjects suffering from stroke control nine...
Rationale: Brain collaterals contribute to improving ischemic stroke outcomes.However, dynamic and timely investigations of collateral blood flow restoration in whole brains living animals have rarely been reported.Methods: Using multiple modalities imaging, including synchrotron radiation angiography, laser speckle micro-CT we dynamically explored circulation throughout the brain rodent middle cerebral artery occlusion model. Results:We demonstrated that compared control animals, 4...
Objectives: Either motor training or repetitive transcranial magnetic stimulation (rTMS) could modulate the neural plasticity after stroke. Therefore, synchronizing two interventions may optimize efficiency of recovery. In present study, we aim to investigate effect rTMS along with hand grip on neurobehavioral and functional recovery in one cohort subacute stroke patients. Methods: Thirty-nine patients were enrolled a single-center, single-blinded, randomized clinical trial. We tested...
Background and AimsThe application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma (HCC) has not been established. Here, we aimed assess the impact Traditional Chinese Medicine Fuzheng Huayu (FZHY) on occurrence HCC in hepatitis B virus-related compensated cirrhosis drug entecavir (ETV).
While neuroplasticity and functional reorganization during motor recovery can be indirectly reflected evaluated by corticomuscular coupling (fCMC), little work has been published regarding the cortical origin of abnormal muscle synergy compensatory mechanism in separation movement stroke patients.
Neuromuscular electrical stimulation (NMES) is a promising assistive technology for stroke rehabilitation. Here we present the design and development of multimuscle system as an emerging therapy people with paretic stroke. A network-based multichannel NMES was integrated based on dual bus architecture communication H-bridge current regulator power booster. The structure body area network embedded multiple stimulators protocol controlled to transmit muscle parameter information individual...
Objective: To investigate the effects of low frequency transcranial magnetic stimulation (LF-rTMS) combined with motor imagery (MI) on upper limb function during stroke rehabilitation. Background: Hemiplegic extremity activity obstacle is a common movement disorder after stroke. Compared single intervention, sequential protocol or combination several techniques has been proven to be better for alleviating disorder. Non-invasive neuromodulation such as repetitive (rTMS) and have verified...
In certain neurological disorders such as stroke, the impairment of upper limb function significantly impacts daily life quality and necessitates enhanced control. This poses a formidable challenge in realm rehabilitation due to its intricate nature. Moreover, plasticity muscle synergy proves advantageous assessing enhancement motor among stroke patients pre post training intervention, owing modular control strategy central nervous system. It also facilitates investigation long-term...
This paper describes the design and test of an automated functional electrical stimulation (FES) system for poststroke rehabilitation training. The aim FES is to synchronize electrically induced movements assist residual patients.In system, accelerometry module detected movement initiation performed by post-stroke patients. desired was displayed in visual game module. Synergy-based patterns were formulated using a normal pattern muscle synergies from healthy subject. Experiment 1 evaluated...
Objective To compare the effects of robot-assisted therapy with conventional for accelerating stratified intervention in poststroke patients upper limb dysfunction. Background For stroke survivors, recovery extremity function remains a major challenge rehabilitation. Literature has suggested that rate may improve if treatments can be individualized to their clinical profiles. However, there still lack evidence on how create treatment tailored individual patients. Robot-assisted Therapy (RT)...
Brain networks allow a topological understanding into the pathophysiology of stroke-induced motor deficits, and have been an influential tool for investigating brain functions. Unfortunately, currently applied methods generally lack in recognition dynamic changes cortical related to muscle activity, which is crucial clarify alterations cooperative working patterns control system after stroke. In this study, we integrate corticomuscular intermuscular interactions cortico-cortical network...
It is evident that the state of art in multi-sensory hand gesture recognition indicates superior performance A-mode ultrasound (AUS) modality over its counterparts. Nevertheless, practical implementation AUS-based real-life scenarios impeded by susceptibility to muscle fatigue, thereby limiting long-term applicability. Therefore, it crucial explore role fatigue stability AUS based human machine interface. Endowing model with adaptability dynamic could potentially offer a viable solution this...