A5079853469- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- DNA Repair Mechanisms
- Digestive system and related health
- Galectins and Cancer Biology
- Reproductive System and Pregnancy
- Glutathione Transferases and Polymorphisms
- Chromosomal and Genetic Variations
- Cardiac Fibrosis and Remodeling
- Preterm Birth and Chorioamnionitis
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- Inflammatory Bowel Disease
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Prion Diseases and Protein Misfolding
- Cancer Genomics and Diagnostics
- Amyotrophic Lateral Sclerosis Research
- Pulmonary Hypertension Research and Treatments
Instituto Aragonés de Ciencias de la Salud
2006-2024
Medizinische Hochschule Hannover
2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2009-2017
Instituto de Investigación Sanitaria Aragón
2011-2017
Kentucky Department of Fish and Wildlife Resources
2015
Instituto de Salud Carlos III
2011
Universidad de Zaragoza
2006
University Hospital Bonn
2005
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2005
Vrije Universiteit Amsterdam
1995-2000
Recent studies have reported an association between cytokine gene polymorphisms and GC risk. However, results are inconsistent among from different geographic regions ethnic groups. Our goal was to evaluate the influence of Helicobacter pylori (H. pylori) infection host genetic factors on susceptibility in a population Spanish white patients.DNA 404 unrelated patients with sex- age-matched healthy controls typed for several functional pro- (IL-1B, TNFA, LTA, IL-12p40) anti-inflammatory...
Animal reintroductions are important tools of wildlife management to restore species their historical range, and they can also create unique opportunities study population dynamics genetics from founder events. We used non-invasive hair sampling in a systematic, closed-population capture-mark-recapture (CMR) design at the Big South Fork (BSF) area Kentucky during 2010 Tennessee 2012 estimate demographic genetic characteristics black bear (Ursus americanus) that resulted reintroduced founding...
Human glutathione S-transferases (GSTs) are phase II metabolizing enzymes that play a key role in protecting against cancer by detoxifying numerous potentially cytotoxic/genotoxic compounds. The genes encoding the human GST isoenzymes GSTM(mu)1, GSTT(theta)1 and GSTP(pi)1 harbour polymorphisms, which have been considered important modifiers of individual risk for environmentally induced cancers such as gastric (GC). However, results inconsistent among studies from different geographic areas...
Two recent genome-wide association studies in Asians have reported the between PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) duodenal ulcer (DU). Since rs2294008 allele frequencies differ notably among ethnicities, we aimed to assess role of on susceptibility GC DU a Caucasian population Spain. Moreover, relevance prognosis was evaluated. Genomic DNA from 603 Spanish patients with primary...
Aliment Pharmacol Ther 31 , 440–451 Summary Background Accumulating evidence suggests that cyclooxygenase‐2 (COX‐2)‐derived prostaglandin E2 (PGE2) is involved in oesophageal adenocarcinogenesis. PGE2 exerts its biological action by binding to specific receptors (EP1, EP2, EP3 and EP4). Aim To investigate which receptor subtypes regulate signals the adenocarcinoma sequence. Methods Expression was determined biopsies from 85 patients with oesophagitis, Barrett’s metaplasia, intraepithelial...
BACKGROUND Our group previously reported the absence of nitric oxide synthase (NOS) in gastroesophageal junction patients with achalasia. NOS exists three distinct isoforms: neuronal (nNOS), endothelial (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by polymorphisms. AIM To assess whether some functional polymorphisms nNOS, iNOS, or eNOS genes are involved susceptibility to suffer from METHODS Genomic DNA 80 unrelated Spanish Caucasian sporadic...
<b><i>Introduction:</i></b> Studies described an increased frequency of hypertensive disorders pregnancy (HDP) after a COVID-19 episode. There is limited evidence about SARS-CoV-2 viral load in placenta. This study aimed to investigate the relationship between placenta and clinical development HDP throughout different periods gestation. <b><i>Methods:</i></b> case-control women with without gestational infection diagnosed by RT-PCR during...
// Patricia Carrera-Lasfuentes 1 , Angel Lanas 1, 2, 3, 4 Luis Bujanda 5 Mark Strunk 6 Enrique Quintero 7 Santos Santolaria 8 Rafael Benito 9 Federico Sopeña 3 Elena Piazuelo Concha Thomson 10 Angeles Pérez-Aisa 11 David Nicolás-Pérez Elizabeth Hijona Jesús Espinel 12 Campo 13 Marisa Manzano 14 Fernando Geijo 15 María Pellise 16 Manuel Zaballa 17 Ferrán González-Huix 18 Jorge Espinós 19 Llúcia Titó 20 Barranco 21 Mauro D'Amato 22 Asunción García-González CIBER de Enfermedades Hepáticas y...
Abstract Background Different polymorphisms have been described as markers to classify the lineages of Mycobacterium tuberculosis complex. The analysis nine single nucleotide (SNPs) was used describe seven SNPs cluster groups (SCGs). We attempted those strains that could not categorized into by genotyping methods in routine testing. Results M. complex isolates collected 2010 our region were analysed. A new method based on multiplex-PCRs and pyrosequencing analyse these designed. For assay...
The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. aim this study was to perform an assessment the placental infection according predominant variant at moment COVID-19 diagnosis. This a prospective SARS-CoV-2-positive pregnant women between March 2020 and 2022. population divided into pregnancies affected disease during (Pre-VOC group) after December (VOC group). presence virus assessed RT-PCR, viral determined whole genome sequencing. A...
Background Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given relevance cytokines and other pro-inflammatory mediators in cancer progression invasiveness, we aimed to assess prognostic role several functional cytokine cyclooxygenase gene polymorphisms patients with GAC. Methodology Genomic DNA from 380 Spanish Caucasian primary GAC was genotyped for 23 (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine,...
and IntroductionHuman endogenous retrovirus (HERV) are the present day versions of retroviral germline infections that have occured millions years ago, which occupy about 8 % genome [1]. While they mostly replication deficient, known to express RNA protein [2] during particular developmental stages, or as a response aging [3], inflammation wide range pathologies [4]. A human discovered in Multiple Sclerosis (MS) patients [5], turned out be prototype novel HERV family referred HERVW [6]. The...
The cancer stem cell (CSC) model suggests that there are subsets of cells within a tumor with increased proliferation and self-renewal capacity, which play key role in therapeutic resistance. importance cyclooxygenase-2 (COX-2) carcinogenesis has been previously established the use COX-2 inhibitors as celecoxib shown to exert antitumor effects. present study investigated whether treatment esophageal adenocarcinoma (EAC) 5-fluorouracil (5-FU) or growth spheres proportion CSCs also if was able...
Aim: The aim of this study was to determine if alterations in DNA methylation the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health. Methods: We evaluated at seven loci differentially methylated pathologies using targeted bisulfite sequencing, placentas (term birth after [n = 15] and 15]), controls (n 15). Results: levels NCAM1 PLAGL1 did differ significantly (p < 0.05) from controls. Discussion: Specific patterns...
Abstract Background/Introduction Myeloid-derived inflammatory macrophages expressing CCR2 are crucial for scar formation and repair after myocardial infarction (MI). Interference with macrophage dynamics impairs healing promotes intraventricular thrombus formation, but the precise of in left ventricle (LV) under these conditions remain unclear. Purpose We investigated impact depletion on infarct expression, microcalcification, cardiac functional outcome mice reperfused MI. Methods Male...