A5065140704- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Sensors
- Dye analysis and toxicity
- Dyeing and Modifying Textile Fibers
- Free Radicals and Antioxidants
- Pesticide Residue Analysis and Safety
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Chemical Sensor Technologies
- Carcinogens and Genotoxicity Assessment
- Photochromic and Fluorescence Chemistry
- Pharmacological Effects and Assays
- DNA and Nucleic Acid Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Effects and risks of endocrine disrupting chemicals
- Chemical Reaction Mechanisms
- Malaria Research and Control
- Synthesis of Organic Compounds
- Medicinal Plants and Neuroprotection
- Drug-Induced Hepatotoxicity and Protection
- Photochemistry and Electron Transfer Studies
- Synthesis and biological activity
- Pharmaceutical Quality and Counterfeiting
University of Ibadan
2014-2025
University of Ilorin
2021
University of Calcutta
2011-2012
Shanghai Institute of Materia Medica
2012
Chinese Academy of Sciences
2012
Obafemi Awolowo University
2009
Background: Citrus limon seeds have limited exploration, compared to other parts. The increasing prevalence of mosquito menace prompted the investigation into repellent effects seed n-hexane extract and fractions (Rutaceae) against adult Anopheles gambiae sl mosquitoes. cytotoxicity chemical constituents 100% n-Hexane Fraction (HF) were also evaluated. Methods: Successive extraction was done with cold-maceration using, n-hexane, Ethyl Acetate (EA) methanol. three solvent extracts screened...
There has been an increasing interest in metabolic syndrome, but few, if any, epidemiological studies on the subject have conducted Nigeria. The purpose of this study was to assess prevalence syndrome a Nigerian rural community.A total 132 participants from three towns southwestern Nigeria were recruited for study. Anthropometric variables, fasting blood glucose, triglyceride, and high-density lipoprotein cholesterol (HDL-C), pressure assessed. survey carried out within 2 months after...
A new approach to the spectrophotometric determination of metronidazole (MZ) and tinidazole (TZ) has been developed. The procedure involves coupling diazotized nitroimidazoles with p-dimethylaminobenzaldehyde (DMAB) form a greenish-yellow solution. Optimal temperature time were 0 degrees C (iced) 3 minutes for diazotization 30 2 both MZ TZ. Coloured adducts TZ showed shoulders at 406 nm 404 nm, respectively, which selected as analytical wavelengths. reaction p-DMAB occurred in 1:1 mole...
A simple, accurate and precise simultaneous spectrophotometric method has been developed for the analysis of trimethoprim–sulphamethoxazole combination in pure tablet dosage forms. The involves direct charge transfer complexation trimethoprim (TMP) with chloranilic acid (CAA) acetonitrile–dioxane solvent mixture sulphamethoxazole (SMZ) after its hydrolysis dilute H2SO4. Optimization temperature time revealed superiority room 20 30 min respectively TMP SMZ. Optimal detector responses were...
A new simple, accurate and cost-effective spectrophotometric method has been developed for the analysis of some cephalosporins (ceftriaxone, ceftazidime, cefixime, cefotaxime cefuroxime) in bulk samples pharmaceutical dosage forms. The reaction involves a two-step process diazotization with acidified NaNO2 at 0–5 °C coupling p-dimethylaminobenzaldehyde (DMAB). Optimal temperature time were established 50 60 ranging from 15 to 20 min. All gave azo adducts DMAB that absorbed light optimally...
A novel colorimetric assay of propranolol tablets has been developed. The is based on chemical derivatization (aromatic ring technique) using diazotized 4-amino-3,5-dinitrobenzoic acid (ADBA) as the chromogenic derivatizing reagent and resultant formation azo dyes. Optimization studies established an optimal reaction time 5 min at 30 degrees C after mixing a Vortex mixer drug/reagent mixture for 10 s. new absorption maximum (lambda(max)) was found 470 nm, which selected analytical...
Purpose: The aim of the present study is to investigate physicochemical equivalence eight brands tablets containing sulfadoxine-pyrimethamine (antimalarial drug combination) sourced from different retail Pharmacy outlets in Nigerian market. Method: quality and combination were assessed. assessment included evaluation uniformity weight, friability, crushing strength, disintegration dissolution tests as well chemical assay tablets. Results: All passed British Pharmacopoeia (BP) standards for...
Due to their enhanced photochromic effects, hydrazone forms of tautomeric azo compounds are commercially preferred as photoreceptors and binary switches. While ortho-hydroxyazo readily exhibit an intramolecular re-arrangement, the predominance tautomers para-hydroxyazo is less frequently observed. The objective this study was design synthesize sulphonated 4-naphthylazo naphth-1-ols with preferential shift. PM6 calculations were used quantify contributions selected structural features...
The applications of various pre-column derivatization reactions are presented in this review. particularly applicable for detection techniques [ultraviolet (UV), fluorescence, chemiluminscence, enantiomeric determination and mass spectrometry (MS)] liquid chromatographic analysis drugs related compounds matrices. This review discovered that an improvement reaction conditions, reagent suitability limits have evolved over the last 60 years. challenge however, still remains ensuring a...
Abstract Background A new sensitive colorimetric determination of nifedipine has been developed following azo dye formation with 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD). Judging from the various generic brands currently now available, this research was conceived as a means developing an alternative cost-effective and readily adaptable method for assay in tablets which official high performance liquid chromatographic technique may not be available. Results Nifedipine reduced Zn/HCl...
A new, simple, cost-effective spectrophotometric method was developed for the determination of olanzapine in pharmaceuticals. The new is based on formation a yellow condensation product with p-dimethylaminobenzaldehyde, followed by measurement absorbance at 410 nm.
The charge-transfer complexation (CTC) formed between olanzapine and chloranilic acid have been studied used as a sensitive colorimetric method for the determination of olanzapine.
Abstract The kinetics of thermal decomposition 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD), an arenediazonium newly developed as a derivatizing reagent for drug analysis, are described. ion, in optimized concentrated sulfuric acid/orthophosphoric acid medium, was incubated various time intervals at 30°, 45°, 55°, 65°, 75°, and 85°C. amount left after each interval quantified selectively by colorimetric assay 490 nm, using mefenamic model diazo-coupling component. rate constants the...