A5043162546- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Alkaloids: synthesis and pharmacology
- Mosquito-borne diseases and control
- Advanced Synthetic Organic Chemistry
- HIV Research and Treatment
- Malaria Research and Control
- Microbial Metabolic Engineering and Bioproduction
- Chemical synthesis and alkaloids
- Enzyme Catalysis and Immobilization
- HIV/AIDS drug development and treatment
- Carbohydrate Chemistry and Synthesis
- Phytochemical compounds biological activities
University of Michigan
2024-2025
Colorado State University
2020
Abstract Despite modern preventative and curative efforts, malaria has remained a major global health crisis. In 2023 alone, was responsible for an estimated 263 million cases 597,000 deaths. To complicate this issue, the causative Plasmodium parasites are becoming more resistant to available therapeutics, making it difficult treat prevent disease progression. Hence, discovery of new antimalarial drugs is crucial mitigating One promising contender natural product premarineosin A,...
The human immunodeficiency virus (HIV)-encoded accessory protein Nef enhances pathogenicity by reducing major histocompatibility complex I (MHC-I) cell surface expression, protecting HIV-infected cells from immune recognition. Nef-dependent downmodulation of MHC-I can be reversed subnanomolar concentrations concanamycin A (1), a well-known inhibitor vacuolar ATPase, at below those that interfere with lysosomal acidification or degradation. We conducted structure–activity relationship study...
Fungal bicyclo[2.2.2]diazaoctane indole alkaloids demonstrate intriguing structures and a wide spectrum of biological activities. Although biomimetic total syntheses have been completed for representative compounds this structural family, the details their biogenesis remained largely uncharacterized. Among them, Brevianamide A represents most basic form within class bearing dioxopiperazine core structure rare 3- spiro - psi -indoxyl skeleton. Here, we identified biosynthetic gene cluster...
<p>Fungal bicyclo[2.2.2]diazaoctane indole alkaloids demonstrate intriguing structures and a wide spectrum of biological activities. Although biomimetic total syntheses have been completed for representative compounds this structural family, the details their biogenesis remained largely uncharacterized. Among them, Brevianamide A represents most basic form within class bearing dioxopiperazine core structure rare 3-<i>spiro</i>-<i>psi</i>-indoxyl skeleton. Here,...