A5076966398- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
Brigham and Women's Hospital
2024
Harvard University
2024
Boston Children's Hospital
2021-2024
Boston Children's Museum
2024
Washington University in St. Louis
2024
Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific cues are transmitted from parents to their descendants poorly understood. Here, we perform metabolic methyl-labeling experiments track the heritable transmission methylation ancestors in nematode Caenorhabditis elegans (C. elegans). We find DNA, RNA, proteins, and lipids. that parental starvation elicits reduced fertility, increased heat stress resistance, extended longevity fed, naïve...
Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome is not fully understood. Whether mRNA transcripts selectively translated in young versus old cells and whether dysregulation this process drives organismal aging unknown. Here we examined role ribosomal RNA (rRNA) methylation maintaining appropriate translation organisms age. In a directed RNAi screen, identified 18S rRNA...
<title>Abstract</title> Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome is not fully understood. Whether mRNA transcripts selectively translated in young versus old cells and whether dysregulation this process drives organismal aging unknown. Here we examined role ribosomal RNA (rRNA) methylation maintaining appropriate translation organisms age. In a directed RNAi screen,...
Summary Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific cues are transmitted from parents to their descendants poorly understood. Here, we perform metabolic methyl-labelling experiments track the heritable transmission methylation ancestors in nematode Caenorhabditis elegans . We find that is proteins, RNA, DNA and lipids. further response parental starvation, fed naïve progeny display reduced fertility, increased heat stress resistance,...
Abstract Post-translational modifications of histone tails alter chromatin accessibility to regulate gene expression. Some viruses exploit the importance by expressing mimetic proteins that contain histone-like sequences sequester complexes recognize modified histones. Here we identify an evolutionarily conserved and ubiquitously expressed, endogenous mammalian protein Nucleolar 16 (NOP16) functions as a H3K27 mimic. NOP16 binds EED in trimethylation PRC2 complex demethylase JMJD3. knockout...