A5017224153- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Facial Trauma and Fracture Management
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- Bone health and treatments
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
Guiyang Medical University
2022-2025
Affiliated Hospital of Guizhou Medical University
2025
XinHua Hospital
2014
Tumors and injuries often lead to large mandibular defects. Accelerating the osteogenesis of bone defect areas is a major concern in current research. In this study, dental pulp mesenchymal stem cells (DPSCs) were used as seed cells, local pulsatile parathyroid hormone (PTH) delivery system was an osteogenic-inducing active ingredient act on DPSCs osteoblasts, which applied jaw area evaluate its therapeutic effect regeneration. Pulsatile systems, both with without PTH, developed following...
Parathyroid hormone (PTH) can promote bone formation and mineralization in mandibular fractures, is systemically administered through daily injections. In this study, the local delivery of PTH using carboxymethyl chitosan/polyvinyl alcohol alginate was investigated. Bovine serum albumin used as a drug substitute, system verified to release drugs pulsed rhythm. After subcutaneously implanted Sprague-Dawley (SD) rats, no rejection reaction detected, indicating that it has good biocompatibility...