A5063897245- Proteoglycans and glycosaminoglycans research
- Pneumocystis jirovecii pneumonia detection and treatment
- Glycosylation and Glycoproteins Research
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Protease and Inhibitor Mechanisms
- Complement system in diseases
- Organ Donation and Transplantation
- Diagnosis and treatment of tuberculosis
- Polysaccharides and Plant Cell Walls
- Nosocomial Infections in ICU
- HIV-related health complications and treatments
- Antibiotic Resistance in Bacteria
- Alcohol Consumption and Health Effects
- Head and Neck Anomalies
- Sarcoidosis and Beryllium Toxicity Research
- RNA Research and Splicing
- Vitamin D Research Studies
- Gastrointestinal disorders and treatments
- Protein Kinase Regulation and GTPase Signaling
- Diverticular Disease and Complications
- Nutrition and Health in Aging
- Biochemical effects in animals
- Congenital Ear and Nasal Anomalies
- Eosinophilic Disorders and Syndromes
Louisiana State University Health Sciences Center New Orleans
1997-2025
Louisiana State University
1996-2020
University Medical Center New Orleans
1996-1999
University of Iowa
1993
Iowa City VA Medical Center
1991
Recent observations have shown that both Chlamydia pneumoniae antigens and DNA may be found within atherosclerotic lesions. In this study, we evaluated the ability of C. to infect cells make up lesions, including endothelial cells, smooth muscle cholesterol-loaded cells. The organism readily infected rabbit, bovine, human aortic Cholesterol-loaded were even more susceptible infection. trachomatis inefficiently demonstrating is not a characteristic all members genus Chlamydia. bovine poorly....
Proteoglycans of the extracellular matrix are vital to growth and evolution malignant neoplasms. The present study determined composition proteoglycans isolated from paired specimens normal breast adenocarcinoma harvested each patient (n = 8). were then tested for their ability stimulate endothelial cell proliferation.Proteoglycans by extraction with 4 M guanidine hydrochloride purified CsCl density-gradient centrifugation. characterized simulate proliferation.In case, total proteoglycan...
To elucidate the correlation between vascular cholesterol metabolism and proteoglycan (PrGl) biosynthesis, we investigated PrGl synthesis in human aortic smooth muscle cells (SMCs) after enrichment with cationized low-density lipoproteins (LDL). Compared normal SMCs, total by cholesterol-enriched decreased 2.4-fold (11874±530 d.p.m. per 105 compared 4890±385 cells). This was net result of a 6.9-fold reduction medium (11000±490 1580± 246 cells) 3.8-fold increase cellular over controls (874±27...
Unit-specific antibiograms have developed to guide clinicians appropriate antibiotic choices for subsets of patients. The additional level a unit- and respiratory-specific antibiogram surgical trauma patients defines key differences in susceptibility information treating hospital-acquired pneumonia.This was three-year, retrospective single-center study. A total 729 positive respiratory specimens from 612 were analyzed using Quality Compass Pathfinder(®), the antibiotic-reporting software....
C8α-γ deficiency was examined in four unrelated African Americans. Two individuals were compound heterozygotes for a previously reported point mutation exon 9. mRNA from the remaining six C8A alleles contained 10 nt insertion between 992 and 993 corresponding to junction exons 6 7. This suggested that these caused by splicing defect. Genomic sequencing revealed G→A intron 6, upstream of 7 acceptor site. converts GG an AG, generates consensus 3' splice site shifts reading frame, creates...
Background and Objectives: Proteoglycans of the extracellular matrix are vital to growth evolution malignant neoplasms. The present study determined composition proteoglycans isolated from paired specimens normal breast adenocarcinoma harvested each patient (n = 8). were then tested for their ability stimulate endothelial cell proliferation. Methods by extraction with 4M guanidine hydrochloride purified CsCl density-gradient centrifugation. characterized simulate Results In case, total...
Abstract Background Elevated levels of procalcitonin (PCT) reflect systemic inflammation associated with bacterial infection (BI). Compared other acute-phase reactants, PCT more rapidly rise BI and decline quickly as improves. A protocol was implemented at University Medical Center New Orleans (UMCNO) in November 2017 that guided discontinuation antimicrobial therapy septic shock patients if clinically improving declining PCT. Methods We performed a retrospective chart review UMCNO 18+ years...