A5088000388- Ocular Oncology and Treatments
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
- Cutaneous Melanoma Detection and Management
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Cell Adhesion Molecules Research
- PARP inhibition in cancer therapy
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Cancer Immunotherapy and Biomarkers
- Nitric Oxide and Endothelin Effects
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Drug Transport and Resistance Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Vasculitis and related conditions
- Transplantation: Methods and Outcomes
- Protein Kinase Regulation and GTPase Signaling
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
Wroclaw Medical University
2016-2025
Wroclaw University of Applied Informatics "Horizon"
2018
Institute of Molecular Pathology and Pathomorphology
2015
Poznan University of Medical Sciences
2012
Estrogen as a potential factor of ovarian carcinogenesis, acts via two nuclear receptors, estrogen receptor alpha (ERα) and beta (ERβ), but the cellular signal pathways involved are not completely clear so far. In this study we have described expression ERα, detected by immunocytochemistry in 11 carcinoma cell lines immunohistochemistry 43 Federation Internationale des Gyneacologistes et Obstetristes stage III specimens prepared before after treatment with cisplatin-based schemes. For...
Cutaneous melanoma is an aggressive cancer and its onset growth are associated, through direct indirect interactions, with the microenvironment. The microenvironment comprises a dynamic complex of numerous types cells (due to histogenesis) that constantly interact each other multiple cytokines signaling proteins. Macrophages one most thoroughly studied pleiotropic immune system. One their major cytophysiological functions involvement in phagocytosis. Previous studies examining melanomas...
The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial. aim the study was to asses status, its correlations with clinicopathological parameters, and impact GC patients. Tumor samples were collected from 78 patients who had undergone curative surgery. In order evaluate intensity immunohistochemical (IHC) reactions two scales applied: immunoreactive score according Remmele modified by authors standardised Hercep test for Hofmann et al. overexpression...
ALCAM (activated leukocyte cell adhesion molecule, CD166, MEMD) is a transmembrane protein of immunoglobulin superfamily (Ig-SF) and plays an important role in human malignant melanoma progression formation locoregional distant metastases. The study using lines showed that overexpression directly related with the increase cytoaggregation ability to form nests. aim was assess expression intracellular localization primary skin melanomas metastatic lesions from regional lymph nodes. Also,...
The aim of this study was to examine the expression ERM (ezrin, moesin) and Rho (RhoA, RhoB Cdc42) proteins in breast cancer (BC) patients investigate relationship between sub-cellular localisation these clinicopathological characteristics patient survival. specific distribution ERM/Rho analysed by immunohistochemistry a homogeneous group 85 stage II ductal BC with follow-up 15 years. Enhanced immunoreactivity all found be associated presence lymph node metastases P = 0.047, moesin, 0.038,...
GOLPH2 and GOLPH3 are Golgi-related proteins associated with aggressiveness progression of a number cancers. Their prognostic significance in melanoma has not yet been analyzed. We performed immunohistochemical analysis for 20 normal skin, 30 benign nevi 100 primary tissue samples evaluated their expression three compartments: cancer cells, tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs). High levels both cells were characteristics aggressive disease, shorter...
Polo-like kinase 1 (PLK1) is a serine-threonine that plays crucial role in the regulation of cell division. In addition, it acts as modulator DNA damage response and novel factor maintenance genome stability during replication. The present study aimed to reveal associations between PLK1 expression clinicopathological features patients with breast cancer (BC), particularly patient survival at 5-, 10- 15-year follow-up. was evaluated immunohistochemically routine diagnostic tissue specimens...
Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional subtypes. Little known about the prognostic significance as well possible associations between PARP1 immunologic response mucosal melanoma. Methods: PARP1, PD-L1 IDO1 immunostains were performed on 192 melanomas including 86 vulvar, 89 sinonasal, 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high expression correlated worse overall melanoma-specific survival (log-rank p...
Summary Background Interleukins and NF κ ‐B are involved in the development of inflammatory reactions. It has been suggested that these proteins important contributing factors process photoaging skin. Moreover, interleukins known to be capable inducing expression cyclooxygenase 2 ( COX ‐2). Expression ‐2 various populations skin cells not examined specific processes aging. Objectives The study aimed at evaluating samples originating from patients with chronologically aged photoaged stages...
The aim of the study was to assess rate neoangiogenesis in extraction wound healing following exposure biostimulating laser therapy and analyze correlation between parameters as reflected by number surface area newly formed blood vessels clinical such gender, position a tooth oral cavity, CD4 lymphocyte count. Twenty-seven patients with confirmed HIV infection were enrolled (6 women, 21 men). Eighty-nine teeth extracted; 45 sockets exposed 6 J radiation (laser set follows: wavelength, 820...
Merkel cell carcinoma is a rare but very aggressive cutaneous tumor. We evaluated the prognostic potential of B-cell markers (terminal deoxynucleotidyl transferase [TdT], PAX5, CD117), follicular stem (CK15, CK19), p63, p53, RB, and polyomavirus (MCPyV; CM2B4) in 136 primary carcinomas.Clinical, histopathologic, immunohistochemical analyses were performed. The results correlated with patient outcomes by Fisher exact test, log-rank tests, Cox multivariate models.By although TdT significantly...
The association of immune markers and clinicopathologic features patient outcome has not been extensively studied in Merkel cell carcinoma (MCC). We correlated tumoral PD-L1 IDO1 expression, intratumoral CD8+ FoxP3+ lymphocytes count with variables, polyomavirus (MCPyV) status, outcomes a series 132 MCC. By univariate analyses, expression >1% combined high lymphocyte improved overall survival (OS) (p = 0.016, 0.0072), MCC-specific (MSS) 0.019, 0.017), progression-free (PFS) 0.043, 0.004,...
The nucleolus is an organelle that ultrastructural element of the cell nucleus observed in H&E staining as a roundish body stained with eosin due to its high protein content. Changes nucleoli cytomorphology were one first histopathological characteristics malignant tumors. aim this study was assess relationship between cytomorphological and detailed clinicopathological parameters melanoma patients. Moreover, we analyzed correlation immunoreactivity selected proteins responsible for, among...