A5040283450- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- Reproductive Biology and Fertility
- Microtubule and mitosis dynamics
- Risk Management in Financial Firms
- RNA Research and Splicing
- Insurance and Financial Risk Management
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
Princeton University
2022
Rutgers, The State University of New Jersey
2020-2021
Past studies offer contradictory claims for the role of genome organization in regulation gene activity. Here, we show through high-resolution chromosome conformation analysis that
Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on chromosomal passenger complex (CPC). To investigate mechanisms that regulate Aurora B activity, we examined role of protein phosphatase 2A (PP2A) oocyte meiosis. We found both forms PP2A, B55 and B56, antagonize function, suggesting a balance between PP2A activity maintains during meiosis I. PP2A-B56, which has subunit encoded by two partially redundant...
Abstract Meiosis in female oocytes lack centrosomes, the major microtubule-organizing center, which makes them especially vulnerable to aneuploidy. In acentrosomal of Drosophila , meiotic spindle assembly depends on chromosomal passenger complex (CPC). Aurora B is catalytic component CPC while remaining subunits regulate its localization. Using an inhibitor activity, Binucleine 2, we found that continuous activity required maintain oocyte during meiosis I, and this antagonized by...