Dielectric microspheres with appropriate refractive index can image objects super-resolution, that is, a precision well beyond the classical diffraction limit. A microsphere is also known to generate upon illumination photonic nanojet, which scattered beam of light high-intensity main lobe and very narrow waist. Here, we report systematic study imaging water-immersed nanostructures by barium titanate glass different size. numerical propagation through points out focusing capability size...

This review explores emerging microfluidic-based technologies incorporating innovative assay strategies for infectious disease diagnostics. Our classification scheme is based on the human body systems or pathogen transmission modes.

Abstract The theoretical and experimental studies of the giant magnetoresistance effect in metallic magnetic multilayers with measuring current perpendicular to interface planes are reviewed. Theoretical formalisms electronic transport inhomogeneous electron gas critically compared emphasis on multilayers. effects roughness, potential steps at interfaces, realistic band structures addressed. determination resistance requires either low-resistance measurement techniques or microfabricated...

Merge, mix, split, and transport are the main manipulation steps used for on-chip droplet-based DNA purification (see figure). The system is able to extract genomic material from dilute raw cell samples by using actuation of magnetic microparticles within droplets through a matrix coils.

We realize a flexible temperature sensor based on micropatterned thin-film platinum resistor. The is situated at the end of 100-mum-wide and 7-cm-long probe. latter consists biocompatible high-temperature-resistant polyimide (U-Varnish-S, UBE Industries, Tokyo, Japan) in which resistor electrical contact leads are embedded. operational from 0degC up to 400degC has time constant less than 80 ms. Such can potentially be used characterize thermo-ablation process tumors using hot steam injection...

We present an original concept of manipulation magnetic microbeads in a microchannel. It is based on the dynamic motion self-assembled structure ferrimagnetic beads that are retained within microfluidic flow using local alternating field. The latter induces rotational particles, thereby strongly enhancing fluid perfusion through behaves as random porous medium. result very strong particle−liquid interaction can be controlled by adjusting field frequency and amplitude, well liquid rate, at...

Super-resolution imaging of sub-cellular organelles and nanostructures is achieved by simply putting high-refractive index glass microspheres on a sample in combination with microscope immersion objective for observation. The microsphere projects the sample's near-field nanoscopic features into far-field, generating magnified virtual image demonstrating resolution four times better than that corresponding to classical diffraction limit.

We have developed a flexible-substrate-based three-axial force sensor, composed of finger-shaped electrode capacitors, whose operation is based on the measurement capacitance change induced upon applying load. The design supports high sensitivity to shear forces. An overall flexibility sensor and elasticity capacitor's dielectric obtained by integrating three polymers in sensor's technology process, namely polyimide, parylene-C, polydimethylsiloxane, combined with standard metallization...

This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating potential immuno-modulatory function dairy food. The core component NutriChip is a miniaturized artificial human gastrointestinal tract (GIT), which consists confluent layer epithelial cells separated from co-culture immune by permeable membrane. setting creates conditions mimicking GIT and allows studying processes that characterize passage nutrients though GIT, including activation...

We detect by optical microscopy Au and fluorescent nanoparticles (NPs) during their motion in water-based medium, using an array of dielectric microspheres that are patterned a microwell template. The act as lenses focusing the light originating from microscope objective into so-called photonic nanojets expose medium within microfluidic channel. When NP is randomly transported through nanojet, its backscattered (for bare NP) or emission instantaneously detected video microscopy. NPs down to...

We have measured the high-angle x-ray diffraction from crystalline Pb-amorphous Ge multilayers. The experimental data in conjunction with a model calculation for fluctuation amorphous-layer thickness show tha this is larger than about 5%. A smaller variation implies existence of peaks which not been observed any amorphous-crystalline

We present the realization and characterization of a new type plastic micropump based on magnetic actuation liquid. The pump consists two serial check-valves that convert periodic motion ferrofluidic plug into pulsed quasi-continuous flow. ferrofluid is actuated by mechanical an external NdFeB permanent magnet. water-based synthesized in-house using coprecipitation method has saturation magnetization 32 mT. various layers polymethylmethacrylate (PMMA), which are microstructured powder...

We study the droplet-based synthesis of fluorescent silica nanoparticles (50-350 nm size) in a microfluidic chip. Fluorescein-isothiocyanate (FITC) dye is first chemically linked to aminopropyl triethoxysilane (APTES) ethanol and this reaction product subsequently mixed with tetraethyl orthosilicate (TEOS) yield silicon alkoxide precursor solution. The latter reacts an aqueous ethanol-ammonia hydrolysing mixture inside droplets, forming nanoparticles. droplets are obtained by pinching-off...

Overcoming the classical diffraction limit in optical microscopy is known to be achievable by a variety of far-field and near-field techniques. More recently, so-called micro-object-based super-resolution techniques have emerged. In this review, we provide an overview state-of-the-art imaging first section, are discussed, which can considered as advanced methods that mostly operate with fluorescent samples. second presented achieve maintaining close distance between nanometric detection unit...

High-refractive index dielectric microspheres positioned within the field of view a microscope objective in medium can focus light into so-called photonic nanojet. A sample placed such nanojet be imaged by with super-resolution, i.e. resolution beyond classical diffraction limit. However, when imaging nanostructures on substrate, propagation distance wave between substrate and microsphere must small enough to reveal sample's nanometric features. Therefore, only central part an image obtained...