A5063885567- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Mechanical Circulatory Support Devices
- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Vitamin K Research Studies
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Epilepsy research and treatment
- Nursing Roles and Practices
- Parvovirus B19 Infection Studies
- Metabolism and Genetic Disorders
- Antimicrobial Resistance in Staphylococcus
- Renal function and acid-base balance
- Pain Management and Opioid Use
- Cystic Fibrosis Research Advances
- Surgical Sutures and Adhesives
- Bone health and osteoporosis research
- Urinary Tract Infections Management
- Electronic Health Records Systems
Queensland Children’s Hospital
2017-2025
The University of Queensland
2021-2025
Children’s Health Queensland Hospital and Health Service
2020-2023
Society of Hospital Pharmacists of Australia
2020-2021
Government of Canada
2014
Royal Children's Hospital
2000-2010
OBJECTIVES: Adjunctive therapy with vitamin C, hydrocortisone, and thiamin has been evaluated in adults, but randomized controlled trial (RCT) data children are lacking. We aimed to test the feasibility of PICU patients septic shock; explore whether intervention is associated increased survival free organ dysfunction. DESIGN: Open-label parallel, pilot RCT multicenter study. The primary endpoint was feasibility. Clinical endpoints included dysfunction censored at 28 days nine secondary...
ABSTRACT Aim To report on the management of a toddler who had accidental ingestion an unknown amount paraquat, with treatment including continuous renal replacement therapy (CRRT), steroids and antifibrinolytics at tertiary‐level health system. Methods A 16‐month‐old child weighing 10 kg accidentally ingested Gramoxone containing paraquat. The was transferred to tertiary centre Paediatric Intensive Care Unit (PICU) where she electively intubated commenced CRRT 7 hours 15 minutes...
OBJECTIVES: Recently, several adult trials have investigated the potential benefit of high-dose vitamin C therapy in critically ill patients. In pediatric patients, little is known on efficacy, safety, and risk therapy. We aimed to review efficacy harm associated with treatment. DATA SOURCES: searched MEDLINE, EMBASE, Cochrane Library, National Institute Health Clinical Trials Register. STUDY SELECTION: included studies neonatal patients who received IV or intra-arterial (ascorbic acid)...
Aims & Objectives: To determine if common antibiotics are adsorbed or cleared by a pediatric RRT circuit. Methods: An ex-vivo closed circuit simulated antimicrobial clearance at ultrafiltrate rate settings used in clinical practice for 3kg infant. The adsorption was assessed over 4 h. concentrations were measured using validated HPLC-MS/MS methodology. Results: Filter (%) each antibiotic the (zero flux: 97 mL/kg/h; low flux 114 and high 131 mL/kg/h) mean recovery h is shown Table 1. 1:...
Aims & Objectives: Pediatric intensive care unit (PICU) admission is a life-threatening event placing survivors at risk for posttraumatic stress disorder (PTSD). This systematic review sought to describe the prevalence of PTSD in PICU and analyze potential risk-factors driving variation estimates. Methods: MEDLINE, Embase, CINAHL, CENTRAL databases were searched from 2000 August 2022, no language restrictions. Stage one screening abstract full text identify studies evaluating post-discharge....
Aims & Objectives: Drug sequestration onto an ECMO circuit may result in suboptimal antibiotic concentrations, treatment failure and the emergence of resistant pathogens. The aim was to determine if common antibiotics are sequestered or degraded during a pediatric simulation. Methods: An ex-vivo model closed established simulate 3 kg infant. Antibiotics were administered as single bolus circuit. Eight plasma samples taken over 7 h A control sample kept under experimental conditions quantify...
Abstract Objective To assess the impact of an “evening” Paediatric Intensive Care Unit (PICU) pharmacist role. Method A pilot program reviewed interventions recorded by extended hours (until 7 pm) in PICU for period 18 April until 16 June 2017. Clinical documented via in‐house pharmacy intervention records were and risk assessed independent multidisciplinary panel consisting a nurse, physician, pharmacist. In addition, medication incidents broader hospital clinical incident database study...
Aims & Objectives: To explore if medication-related incidents either precipitate or occur during a medical emergency team (MET) response. Methods: A mixed methods approach was used for this project. retrospective audit of the in-house MET database and patient safety reporting system reviewed all suspected between January until December 2018. prospective observational real-time conducted on medications administered at March June 2019. descriptive analysis performed with results presented as...
Introduction: Residents in nursing homes are known to be at high risk for low Vitamin D levels, falls, decreased mobility and cognitive impairment. This study was done evaluate status, bone health muscle function this vulnerable population. Methods: Subjects were recruited from five home facilities Edmonton, Canada. Ethics approval consent obtained. Chart review blood work done. Bone density assessed using a portable calcaneal ultrasound device (Hologic Sahara). Muscle strength grip...
Transplantation: July 27, 2008 - Volume 86 Issue 2S p 618 doi: 10.1097/01.tp.0000330880.25130.03