A5060048686- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Hip and Femur Fractures
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Diet and metabolism studies
- Child Nutrition and Feeding Issues
- Enhanced Recovery After Surgery
- Muscle metabolism and nutrition
- Frailty in Older Adults
- Traumatic Brain Injury and Neurovascular Disturbances
- Family and Patient Care in Intensive Care Units
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Nutrition and Health
- Abdominal Surgery and Complications
- Esophageal and GI Pathology
- Diabetes Management and Research
- Dysphagia Assessment and Management
- Cardiac and Coronary Surgery Techniques
- Delphi Technique in Research
- Systemic Sclerosis and Related Diseases
- Nutritional Studies and Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Inflammatory Myopathies and Dermatomyositis
The University of Adelaide
2016-2025
Royal Adelaide Hospital
2017-2025
Australian and New Zealand Intensive Care Society
2023-2025
Monash University
2023-2025
National Health and Medical Research Council
2016-2024
Centre for Cancer Biology
2022
Royal Hospital
2019
Creative Research Enterprises (United States)
2017
The Royal Melbourne Hospital
2017
The University of Melbourne
2017
Rationale: Dietary protein may attenuate the muscle atrophy experienced by patients in ICU, yet handling is poorly understood. Objectives: To quantify digestion and amino acid absorption fasting postprandial myofibrillar synthesis during critical illness. Methods: Fifteen mechanically ventilated adults (12 male; aged 50 ± 17 yr; body mass index, 27 5 kg⋅m−2) 10 healthy control subjects (6 54 23 4 received a primed intravenous L-[ring-2H5]-phenylalanine, L-[3,5-2H2]-tyrosine,...
Coronavirus disease 2019 (COVID-19) results from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features and subsequent medical treatment, combined with the impact of a global pandemic, require specific nutritional therapy in hospitalised adults. This document aims to provide Australian New Zealand clinicians guidance on managing critically acutely unwell adult patients COVID-19. These recommendations were developed using expert consensus, incorporating documented...
Slow gastric emptying occurs frequently during critical illness and is roughly quantified at bedside by large residual volumes (GRVs). A previously published trial (The Augmented versus Routine approach to Giving Energy Trial; TARGET) reported larger GRVs with energy-dense (1.5 kcal/mL) compared standard (1.0 enteral nutrition (EN), warranting further exploration. To assess the incidence, risk factors, duration, timing of (≥250 mL) its relation clinical outcomes in mechanically ventilated...
It is unknown whether increasing dietary protein to 1.2-2.0 g/kg/day as recommended in international guidelines compared current practice improves outcomes intensive care unit (ICU) patients. The TARGET Protein trial will evaluate this.
Abstract Background Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, little information relationships between and clinical outcomes in population. Methods We undertook an analysis observational data, collected prospectively as part International Nutrition Surveys 2007-2013, extracted obtained from critically ill patients trauma. Our...
Abstract Background Nutrition interventions commenced in ICU and continued through to hospital discharge have not been definitively tested critical care date. To commence a program of research, we aimed determine if tailored nutrition intervention delivered for the duration hospitalisation delivers more energy than usual patients initially admitted Intensive Care Unit (ICU). Methods A multicentre, unblinded, parallel-group, phase II trial was conducted twenty-two hospitals Australia New...
Abstract Background The TARGET Protein trial will evaluate the effect of greater enteral protein delivery (augmented protein) on clinical outcomes critically ill adult patients when compared to usual care. Objective To describe statistical analysis plan for trial. Methods is a cluster randomized, cross-sectional, double cross-over, open-label, registry-embedded, pragmatic conducted across Australia and New Zealand. randomized eight intensive care units (ICU) receive formula containing either...
Oral intake is the most common route of nutrition following intensive care unit (ICU) discharge; yet associated with inadequate intake, and barriers are largely unknown. This study aimed to determine prevalence severity symptoms that may impact oral (termed nutrition-impacting symptoms) in ICU survivors. A single-center descriptive cohort quantified survivors at (T1) hospital (T2) discharge 1 month posthospital (T3) via patient-reported questionnaires. Secondary outcomes were status (via...
International guidelines recommend critically ill adults receive more protein than most receive. We aimed to establish the feasibility of a trial evaluate whether feeding international recommendations would improve outcomes, in which 1 group received doses representative guideline (high protein) and other similar usual practice.We conducted prospective, randomized, blinded, parallel-group, across 6 intensive care units. Critically ill, mechanically ventilated expected enteral nutrition (EN)...
Background and aims: Patients admitted to the ICU with a traumatic brain injury (TBI) are at risk of muscle wasting but this has not been quantified. Our aims were describe longitudinal changes in anthropometrical data, compare accuracy non-invasive methodologies validated dual-energy x-ray absorptiometry (DXA), assess relationships between data self-reported physical function. Methods: In prospective observational study, we recruited patients moderate-to-severe TBI over 12 months....
Abstract Background Intensive care unit (ICU) survivors have reduced oral intake; it is unknown whether intake and associated barriers are unique to this group. Objective To quantify energy potential in ICU compared with general medical (GM) patients healthy volunteers. Design A descriptive cohort study survivors, GM patients, Following an overnight fast, participants consumed a 200 ml test‐meal (213 kcal) 180 min later ad libitum meal measure (primary outcome). Secondary outcomes; taste...
Objective: To evaluate the effect of exogenous glucagon-like peptide-1 (GLP-1) on small intestinal glucose absorption and blood concentrations during critical illness. Design, setting participants: A prospective, blinded, placebo-controlled, cross-over, randomised trial in a mixed medical–surgical adult intensive care unit, with 12 mechanically ventilated critically ill patients, who were suitable for receiving nutrient. Interventions: On consecutive days, order, participants received...