A5025111311- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Medical Education and Admissions
- Innovations in Medical Education
- Neuroscience and Neuropharmacology Research
- Enzyme Structure and Function
- Adolescent Sexual and Reproductive Health
- Protein Structure and Dynamics
- Vagus Nerve Stimulation Research
- Cholinesterase and Neurodegenerative Diseases
- RNA and protein synthesis mechanisms
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Bacterial Genetics and Biotechnology
- Health and Medical Research Impacts
- Diversity and Career in Medicine
- Biochemical effects in animals
- HIV/AIDS Research and Interventions
- Diabetic Foot Ulcer Assessment and Management
- Reproductive tract infections research
- Heat shock proteins research
Campbell University
2020-2023
St. Joseph's Hospital and Medical Center
2004-2014
National Taiwan University Hospital
2011
National Taiwan University
2011
National Yang Ming Chiao Tung University
2011
Barrow Neurological Institute
2001-2009
The Ohio State University
1997
Abstract The expression of nicotinic acetylcholine receptors by neurons, microglia, and astrocytes suggests possibly diverse mechanisms which natural cholinergic signaling exposure to nicotine could modulate immune responses within the CNS. In this study, we show that significantly delays attenuates inflammatory autoimmune myelin Ags in mouse experimental encephalomyelitis model. periphery, inhibits proliferation autoreactive T cells alters cytokine profile helper cells. CNS, selectively...
Amyloid-beta (Abeta) accumulation and aggregation are thought to contribute the pathogenesis of Alzheimer's disease (AD). In AD, there is a selective decrease in numbers radioligand binding sites corresponding most abundant nicotinic acetylcholine receptor (nAChR) subtype, which contains human alpha4 beta2 subunits (halpha4beta2-nAChR). However, relationships between these phenomena uncertain, effects Abeta on halpha4beta2-nAChR function have not been investigated detail. We first confirmed...
Naturally expressed nicotinic acetylcholine receptors (nAChR) containing alpha4 subunits (alpha4*-nAChR) in combination with beta2 (alpha4beta2-nAChR) are among the most abundant, high-affinity nicotine binding sites mammalian brain. beta4 also richly and colocalize several brain regions implicated behavioural responses to dependence. Thus, alpha4beta4-nAChR may exist play important functional roles. In this study, properties were determined of human alpha4beta2- heterologously de novo...
Background: Diabetes is known to impair wound healing and deteriorate the periodontal condition. There limited information about patterns events associated with repair. In this study, we evaluate dynamics of repair using micro‐computed tomography (microCT) immunohistochemistry. Methods: Thirty‐six male rats were used, diabetes was induced by streptozotocin. The maxillary first molars extracted, a tooth‐associated osseous defect created in extraction area. Animals sacrificed after 7, 14, 21...
As the number of medical school graduates continues to outpace available residency training positions, applying for in United States has become a highly competitive process, often associated with low rate selection and invitation interview. The National Resident Matching Program (NRMP) Director survey provides data assessing factors considered by Directors (PD) selecting inviting candidates Assessing evolution these over time is efficacious inform guide prospective applicants toward...
Effects of cytisine (cy), 3‐bromocytisine (3‐Br‐cy), 5‐bromocytisine (5‐Br‐cy) and 3,5‐dibromocytisine (3,5‐diBr‐cy) on human (h) α7‐, α4β2‐ α4β4 nicotinic acetylcholine (nACh) receptors, expressed in Xenopus oocytes cell lines, have been investigated. Cy its bromo‐isosteres fully inhibited binding both [α‐ 125 I]bungarotoxin ([α‐ I]BgTx) to hα7‐ [ 3 H]cy hα4β2‐ or hα4β4‐nACh receptors. 3‐Br‐cy was the most potent inhibitor I]BgTx binding. less than 3‐Br‐cy, but 5‐Br‐cy 3,5‐diBr‐cy were...
The expression of two heat-responsive cct (chaperonin-containing Tcp-1) genes from the archaeon Haloferax volcanii was investigated at transcription level. cct1 and cct2 genes, which encode proteins 560 557 amino acids, respectively, were identified on cosmid clones an H. genomic library subsequently sequenced. deduced acid sequences these exhibited a high degree similarity to other archaeal eucaryal family members. Expression characterized in detail for purpose developing model studying...
To evaluate possible physiological roles of the large cytoplasmic loops (C2) and neighboring transmembrane domains nicotinic acetylcholine receptor (nAChR) subunits, we generated novel fusion constructs in which human nAChR α4, β2, or β4 subunit C2 sequences were replaced by corresponding from mouse serotonin type 3A (5-HT<sub>3A</sub>) subunit. Following stable expression SH-EP1 cells, found that extensive sequence substitutions involving third fourth “proximal” (e.g., β2 H322-V335...
Uninsured patients living in rural areas of North Carolina have been inordinately affected by the increasing prevalence sexually transmitted diseases (STDs) midst severe budget cuts to treatment programs and a shortage primary care physicians. The Campbell University Community Care Clinic, self-funded, student-run clinic, provides free health uninsured residents Harnett County. As relatively new clinic serving unique population, epidemiologic research is paramount clinic's continued...
Medical education curricula have been increasingly undergoing changes in recent years to respond continuous transformations the professional landscape. Utilizing and promoting learning approaches that are most effective helping learners navigate through these ongoing changes, while fostering optimal educational outcomes, of particular importance. While there various approaches, they can be categorized into three main types: Superficial, Deep, Strategic. Although Strategic Deep Learning were...