A5062296273- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chromatin Remodeling and Cancer
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- PARP inhibition in cancer therapy
Ludwig-Maximilians-Universität München
2018-2025
Munich Leukemia Laboratory (Germany)
2021-2025
Deutschen Konsortium für Translationale Krebsforschung
2024-2025
German Cancer Research Center
2025
Heidelberg University
2025
LMU Klinikum
2018-2025
Abstract The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during germinal center (GC) reaction. Failure to eliminate potentially harmful via can lead lymphoproliferation development malignancies. classic form follicular lymphoma (FL) is a prototypic GC-derived malignancy, characterized by t(14;18)(q32;q21)IGH:: BCL2 translocation overexpression antiapoptotic BCL2. Additional alterations were shown be clinically relevant, including mutations...
The variable clinical course of follicular lymphoma (FL) is determined by the molecular heterogeneity tumor cells and complex interactions within microenvironment (TME). IL-4 producing helper T (TFH) are critical components FL TME. Binding to IL-4R on activates JAK/STAT signaling. We identified STAT6 mutations (STAT6MUT) in 13% (N = 33/258), all clustered DNA binding domain. Gene expression data immunohistochemistry showed upregulation IL-4/STAT6 target genes STAT6MUT FL, including CCL17,...
Abstract High-dose therapy and autologous stem cell transplantation (HDT/ASCT) is an effective salvage treatment for eligible patients with follicular lymphoma (FL) early progression of disease (POD). Since the introduction rituximab, HDT/ASCT no longer recommended in first remission. We here explored whether consolidative improved survival defined subgroups previously untreated patients. report analyses 431 who received frontline cyclophosphamide, doxorubicin, vincristine, prednisone...
Summary Relapsed follicular lymphoma (FL) can arise from common progenitor cells (CPCs). Conceptually, CPC‐defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B‐cell leukaemia/lymphoma 2 ( BCL2 )/immunoglobulin heavy locus IGH ) translocations other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find in purified / ‐negative haematopoietic clinical remission samples three patients with FL....
ABSTRACT The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during germinal center (GC) reaction. Failure to eliminate potentially harmful via can lead lymphoproliferation development malignancies. classic form follicular lymphoma (FL) is a prototypic GC-derived malignancy, characterized by t(14;18) (q32;q21)IGH:: BCL2 translocation overexpression antiapoptotic BCL2. Additional alterations were shown be clinically relevant, including mutations...