A5102840078- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Neurological Disorders and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Medicinal Plants and Neuroprotection
- Peripheral Artery Disease Management
- Pharmacological Effects of Medicinal Plants
- Central Venous Catheters and Hemodialysis
- Pelvic floor disorders treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ginkgo biloba and Cashew Applications
- Osteoarthritis Treatment and Mechanisms
- Dermatologic Treatments and Research
- Bee Products Chemical Analysis
- Urinary Tract Infections Management
- Neurological Disease Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Thermoregulation and physiological responses
- Musculoskeletal pain and rehabilitation
- Wound Healing and Treatments
- Menopause: Health Impacts and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Urinary Bladder and Prostate Research
Irvine Valley College
2020-2024
International Atomic Energy Agency
2023
University of Chieti-Pescara
1998-2021
Azienda USL di Pescara
2010-2021
Indena (Italy)
2021
National Center for Genetic Engineering and Biotechnology
2015
Pulmonary Vascular Research Institute
2009
University of Münster
2006-2008
St. Mary’s Hospital
1998-2007
University of L'Aquila
2006
The aim of the present study was to evaluate effects different treatment plans (compression only, early surgery, low-dose subcutaneous heparin [LDSH], low- molecular-weight [LMWH], and oral anticoagulant [OC] treatment) in management superficial thrombophlebitis (STP), by considering efficacy costs a 6-month, randomized, follow-up trial. Patients with STP, large varicose veins without any suspected/documented systemic disorder, were included. Criteria for inclusion as follows: presence...
The study compared, by a prospective, randomized method, 6 treatment options: A: Sclerotherapy; B: High-dose sclerotherapy; C: Multiple ligations; D: Stab avulsion; E: Foam-sclerotherapy; F: Surgery (ligation) followed sclerotherapy. Results were analyzed 10 years after inclusion and initial treatment. Endpoints of the variations in ambulatory venous pressure (AVP), refilling time (RT), presence duplex-reflux, number recurrent or new incompetent sites. patients, limbs, treated segments...
The LONFLIT1/2 studies have established that in high-risk subjects after long (> 10 hours) flights the incidence of deep venous thrombosis (DVT) is between 4% and 6%. LONFLIT4 study has been planned to evaluate control edema DVT low-medium-risk subjects. aim this was its with specific flight stockings, long-haul flights. In first part 400 at low-medium risk for were contacted; 28 excluded several nonmedical problems; 372 randomized into 2 groups prophylaxis stockings 7-8-hour flights; group...
Abstract The aim of this double‐blind, placebo‐controlled study was to evaluate the efficacy 100 mg Pycnogenol ® daily (oral capsules) in a 3 month patients with osteoarthritis (OA). OA symptoms were evaluated by WOMAC scores, mobility recording their walking performance (treadmill). Treatment (77 patients) and placebo group (79) comparable for age, sex distribution, distances use antiinflammatory drugs. global score decreased 56% ( p < 0.05) treatment versus 9.6% group. Walking distance...
The study was planned to evaluate efficacy and costs of endovascular sclerotherapy (ES) in comparison with surgery associated a prospective (10-year follow-up), good-clinical-practice study. Patients varicose veins pure, superficial venous incompetence were included. Of the patients randomized into three groups 39 (group A) treated ES, 40 (B) + sclerotherapy, 42 only (C). Surgery consisted ligation SFJ (saphenofemoral junction) incompetent detected color duplex. preselected 150 patients, 121...
In a previous, double-blind, placebo-controlled study we evaluated the efficacy of 3-month treatment with Pycnogenol for 156 patients osteoarthritis knee. significantly decreased joint pain and improved function as using WOMAC score walking performance on treadmill. this study, further investigated anti-inflammatory antioxidant activity in subset presenting elevated C-reactive protein (CRP) plasma-free radicals. Elevated CRP levels have been suggested to be associated disease progression...
Study Type – Therapy (RCT) Level of Evidence 1b OBJECTIVE To assess the effects a complex plant extract (Prelox®, formulation pine bark and l ‐arginine aspartate; Horphag Research UK Ltd, London, UK) on erectile dysfunction (ED) in men, as sexual desire typically persists ageing while their endothelial function gradually declines. PATIENTS AND METHODS In this double‐blind, placebo‐controlled study we assessed Prelox 124 patients (aged 30–50 years) with moderate ED over an investigational...
The aim of this study was to evaluate the development edema, and superficial deep vein thrombosis (DVT) prophylaxis with an oral profibrinolytic agent (Flite Tabs, 150 mg pinokinase, Aidan, Tempe, AZ, USA) in long-haul flights (7-8 hours), high-risk subjects. A group 300 subjects included; 76 were excluded for several problems including concomitant treat ments ; 204 randomized into 2 groups (active treatment or placebo) effects Flite Tabs. An exercise program used both groups. femoral,...
The aim of this study was to investigate the clinical efficacy oral Pycnogenol ® (Horphag Research Ltd, United Kingdom) in patients with diabetic microangiopathy. Patients without a history ulcerations were treated Pycnogenol. received (50 mg capsules, 3 times daily for total 150 4 weeks). A group 30 included (severe microangiopathy); comparable observed as controls (no treatment during observation period). All (age, 59 years; range, 55-68 male:female = 18:12) completed 4-week study. Also,...
This open, controlled study evaluated the effects of 6 month supplementation with Pycnogenol® maritime pine bark extract on health risk factors in subjects metabolic syndrome. was used aim improving associated syndrome, central obesity, elevated triglycerides (TG), low HDL cholesterol, high blood pressure and fasting glucose. Sixty‐four (range 45–55 years) presenting all five syndrome were included, administered for months. A group 66 equivalent followed up as controls. In 6‐month 150 mg/day...
The purpose of this study was to evaluate the long-term efficacy and safety a lecithin-based delivery form boswellic acids from Boswellia serrata (Casperome®) for prevention symptoms in otherwise healthy subjects with mild irritable bowel syndrome (IBS).The included 69 participants IBS who completed 6-month follow-up period. In total, 34 were assigned standard management (SM) group: diet and, if needed, hyoscine butylbromide (Buscopan®) or papaverine hydrochloride + 10 mg Atropa belladonna...
The aim of this study was to confirm the clinical efficacy oxerutins by evaluation venous parietal tone and microvascular perfusion in a double-blind, randomized, placebo-controlled study. included 60 patients. Venous evaluated air-plethysmography (APG) patients with insufficiency (CVI). Forty were treated 20 placebo for 4 weeks. dose first 2 weeks higher than that following age range between 18 65 years. Randomized received treatment (oxerutins or placebo) according grade CVI. Patients I...
Diabetic microangiopathy leads to lower limb ulcers that are very slow heal. Pycnogenol was evaluated on diabetic in a controlled trial. Ulcer medications were used 4 groups (30 patients): (1) systemic and local application; (2) only; (3) oral Pycnogenol; (4) only (control group). Ulcerated areas symptom scores more reduced with the combined treatment (P < .05). Oral less effective, but still improved compared controls. Combined produced 89% complete healing at 6 weeks versus 84% 85%...
The aim of this open supplement study was to evaluate the effects Pycnogenol® in comparison with controls on symptoms post-COVID-19 syndrome and improving endothelial function, microcirculation, inflammatory markers oxidative stress over 3 months symptomatic subjects recovering from COVID-19.Sixty COVID-19 were included. One group 30 followed a standard recovery management while comparable received 150 mg daily (in doses 50 mg) addition management.Two groups selected at baseline....
Chronic venous insufficiency (CVI) is the consequence of valve reflux and/or flow obstruction and resulting hypertension in lower extremities. The aim this prospective supplement registry study was to evaluate efficacy compression stockings or Pycnogenol
Fifty patients with diabetic microangiopathy were studied by laser Doppler flowmetry (measuring skin blood flow at rest) (RF) and the venoarteriolar response (VAR), transcutaneous PO2 PCO2 measurements, capillary permeability evaluation (rate of ankle swelling [RAS]). Thirty these treated for 6 months total triterpenic fraction Centella asiatica (TTFCA) (60 mg twice daily), a drug active on microcirculation permeability. A control group ten was placebo another left without treatment thus...
Background: The LONFLIT1+2 studies have established that in high risk subjects after long flights (> 10 hours) the incidence of deep venous thrombosis (DVT) is between 4% and 6%. LONFLIT4 study was designed to evaluate control edema DVT low-medium subjects. aim this its with specific stockings (ankle pressure 20 30 mm Hg) long-haul flights. first part included lasting 7-8 hours second 11-12 hours. Ultrasound scans were used assess before a composite score swelling. A group patients...