A5077169260- Natural Antidiabetic Agents Studies
- Pancreatic function and diabetes
- Advanced Glycation End Products research
- Biochemical Acid Research Studies
- Alcoholism and Thiamine Deficiency
- Fungal Biology and Applications
- Diet, Metabolism, and Disease
- Curcumin's Biomedical Applications
- Immune Cell Function and Interaction
- Phytochemicals and Antioxidant Activities
- Environmental Toxicology and Ecotoxicology
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Oral microbiology and periodontitis research
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- PARP inhibition in cancer therapy
- Antioxidants, Aging, Portulaca oleracea
- Pesticide Exposure and Toxicity
University of Belgrade
2015-2025
Institute for Biological Research “Siniša Stanković”
2009-2022
Institute for Biological Sciences
2007-2019
University of Oxford
2006-2008
Major histocompatibility complex (MHC) class I chain-related protein A (MICA) and MHC B (MICB) are polymorphic proteins that induced upon stress, damage or transformation of cells which act as a 'kill me' signal through the natural-killer group 2, member D receptor expressed on cytotoxic lymphocytes. MICA/B not thought to be constitutively by healthy normal but expression has been reported for most tumour types. However, it is clear how much this cell surface. Using novel, well-characterised...
// Geoffrey S. Williams 1 , Bina Mistry Sandrine Guillard Jane Coates Ulrichsen Alan M. Sandercock Jun Wang 2 Andrea González-Muñoz Julie Parmentier 3 Chelsea Black 4 Jo Soden 5 Jim Freeth Jelena Jovanović Rebecca Leyland Rafia Al-Lamki Andrew J. Leishman Steven Rust Ross Stewart Lutz Jermutus John R. Bradley Vahe Bedian Viia Valge-Archer Ralph Minter Robert W. Wilkinson MedImmune Ltd., Granta Park, Cambridge, CB21 6GH, UK Department of Medicine, University Addenbrooke’s...
Diabetic foot ulcers have an enormous impact on patients’ quality of life and represent a major economic burden. The cause is delayed incomplete wound healing due to hyperglycemia, reduced blood flow, infections, oxidative stress chronic inflammation. Plasma-activated water (PAW) emerging as new therapeutic approach in treatment, it has many the advantages cold atmospheric plasma but easier apply, thus allowing for widespread use. aim this study was investigate potential PAW improve diabetic...
Portal vein thrombosis (PVT) is a partial or complete obstruction of blood flow through the portal (PV) due to an intraluminal thrombus. Neoplastic common complication in cases hepatocellular carcinoma (HCC), and it sign poor prognosis. Diagnosing HCC tumor PVT usually performed using non-invasive radiological imaging measuring marker levels. Sometimes, present without any detectable liver mass conclusive findings. In like these, biopsy for confirmation. available literature, either...
Abstract Antibody–drug conjugates (ADC) are used to selectively deliver cytotoxic agents tumors and have the potential for increased clinical benefit cancer patients. 5T4 is an oncofetal antigen overexpressed on cell surface in many carcinomas both bulk tumor cells as well stem (CSC), has very limited normal tissue expression, can internalize when bound by antibody. An anti-5T4 antibody was identified optimized efficient binding internalization a target-specific manner, engineered cysteines...
The objective of this work was to investigate the effects methanol extracts of<italic>Gentiana cruciata L.</italic>dilate against carbon tetrachloride-induced liver injury in rats.
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system signals involved in controlling T-cell activation. Targeting and agonizing GITR mice promotes antitumor immunity by enhancing the function effector T cells inhibiting regulatory cells. Here, we describe MEDI1873, novel hexameric human agonist comprising an IgG1 Fc domain, coronin 1A trimerization domain GITRL extracellular (ECD). MEDI1873 was optimized through systematic testing different...
Due to intrinsically low levels of antioxidant enzyme expression and activity, insulin producing pancreatic β-cells are particularly susceptible free radical attack. In diabetes mellitus, which is accompanied by high oxidative stress, this feature significantly contributes their damage dysfunction. light the documented pro-survival effect chemokine C-X-C Ligand 12 (CXCL12) on β-cells, we examined its potential role in protection. We report that CXCL12 overexpression enhanced resistance rat...
The aim of this study was to assess the in vivo effects extract medicinal mushroom, Lactarius deterrimus, when administered (60 mg/kg, i.p.) daily for four weeks streptozotocin- (STZ-) induced diabetic rats. Diabetic rats treated with L. deterrimus displayed several improved biochemical parameters circulation: reduced hyperglycemia, lower triglyceride concentration and glycated hemoglobin, serum protein, advanced glycation end product (AGE) levels. This treatment also adjusted...
The present study aimed to investigate the effects of treatment with α-lipoic acid (LA), a naturally occurring compound possessing antioxidant activity, on liver oxidant stress in rat model streptozotocin (STZ)-induced diabetes by examining potential mechanistic points that influence changes expression enzymes such as catalase (CAT) and CuZn/Mn superoxide dismutase(s) (SOD). LA was administered for 4 weeks daily intraperitoneal injections (10 mg/kg) STZ-induced diabetic rats, starting from...
The present study aimed to investigate the beneficial effects of treatment with extracts from edible mushroom Lactarius deterrimus (Ld) and chestnut Castanea sativa (Cs), separately in combination (MIX Ld/Cs), on oxidative stress advanced glycation end-product (AGE)-mediated hepatorenal injury a rat model streptozotocin (STZ)-induced diabetes by examining pathways responsible for maintenance redox homeostasis. An experimental was induced rats administration 40 mg/kg STZ intraperitoneally...
Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In present study, we tested extracts from edible mushroom Lactarius deterrimus chestnut Castanea sativa , as well their mixture (MIX Ld / Cs ), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic death. Analysis chelating effects, reducing power radical-scavenging assays revealed strong antioxidant C. extract MIX while L. displayed a weak...
Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact CXCL12 expression on prosurvival phenotype initiated this study. Our aim was to provide novel insight into regulation rat gene (Cxcl12) transcription. roles poly(ADP-ribose) polymerase-1 (PARP-1) transcription factor Yin Yang 1 (YY1) in Cxcl12 were studied by...