A5021467465- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Immunotherapy and Immune Responses
- Pelvic floor disorders treatments
- CAR-T cell therapy research
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Testicular diseases and treatments
- Ureteral procedures and complications
- MRI in cancer diagnosis
- Sexual function and dysfunction studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Advanced X-ray and CT Imaging
- Renal and Vascular Pathologies
- Medical and Health Sciences Research
- Bone health and treatments
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
1980-2025
München Klinik
2025
Klinik und Poliklinik für Urologie
2021-2023
Center for Integrated Protein Science Munich
2014-2018
German Center for Lung Research
2016-2018
University of Fribourg
2014
Helmholtz Zentrum München
2014
Roche (Switzerland)
2014
University Hospital Cologne
2014
Adoptive T cell transfer (ACT) is currently under investigation for the treatment of metastatic cancer. Recent evidence suggests that coinhibitory PD-1-PD-L1 axis plays a major role in ACT failure. We hypothesized new fusion receptor reverting PD-1-mediated inhibition into CD28 costimulation may break peripheral tolerance.Different PD-1-CD28 constructs were created and retrovirally transduced primary transgenic murine CD8(+) cells specific ovalbumin (OT-1). Cytokine release, proliferation,...
Modern risk stratification of prostate cancer (PCa) allows for prediction advanced disease with a high level certainty. We aimed to evaluate prospective series patients undergoing radical prostatectomy without prior biopsy based solely on clinical criteria and imaging results. The were divided into three groups. Group 1 included 27 with: (i) suspicious digital rectal examination, (ii) PSA ≥ 10 ng/mL, (iii) PI-RADS 4/5 mpMRI, (iv) suspicion PCa PSMA-PET. 2 six who fulfilled i, ii, iii but did...
Major urological guidelines do not currently recommend robot-assisted surgery compared with laparoscopic or open due to the lack of high-quality evidence. We aimed provide real-world data on evolution robotic urology and compare its perioperative outcomes those surgeries.
Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost response purified antigens intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates potentially combining antigenic and properties one substance. To more precisely characterize potential Escherichia coli OMV vaccination with heterologous antigens, responses AnAPN1 Pfs48/45 as well...
Real-world data exploring the perioperative outcomes of different surgical treatments for benign prostatic hyperplasia (BPH) are lacking. We aimed to assess trends BPH surgeries and compare their outcomes. used GeRmAn Nationwide inpatient Data (GRAND), provided by Research Center Federal Bureau Statistics (2005-2022), performed multiple patient-level analyses. Our study included 1 355 845 BPH. Of these, 084 650 (79.9%) were transurethral resection prostate (TURP), 90 735 (6.9%) simple...
Abstract Purpose Despite the high incidence of perioperative complications following cystectomy, there is a lack evidence regarding patients’ perceptions. Moreover, discrepancies between established complication grading systems and patient’s perspective remain unexplored. Methods We prospectively evaluated after cystectomy using Clavien-Dindo Classification (CDC) Comprehensive Complication Index (CCI). The CDC CCI were compared to patient-reported grades through Spearman correlation...
Background and Objective: The cost of imaging interventions in the surgical field varies between countries sometimes within different regions same country. Procedural takes into account equipment, consumables, operating room, surgical, anesthetic nursing teams, radiology, medications, hospital stay. Health care systems therefore face an incredible burden related to investigations procedures. aim this study was collect costs for kidney calculi across hospitals health world. Methods: An online...
Current evidence suggests that prior prostatic interventions, such as prostatectomy, radiation, or transurethral surgery may increase the risk of incontinence in patients undergoing radical cystectomy (RC) with ileal orthotopic neobladder reconstruction. We aimed to evaluate short- and long-term complications, functional outcomes reconstruction RC after procedures. analyzed who underwent intervention our department from 2013-2022. A comparison was made between receiving (ONB) versus conduit,...
De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown.
Background:One bottleneck for adoptive T cell therapy (ACT) is recruitment of cells into tumors. We hypothesized that combining tumor-specific cells, modified with a marker antigen and bispecific antibody (BiAb) selectively recognizes transduced tumor would improve to tumors enhance therapeutic efficacy.
Background: Interaction of the programmed death receptor 1 (PD-1) and its ligand, PD-L1, suppresses T cell activity permits tumors to evade cell-mediated immune surveillance. We have recently demonstrated that antigen-specific CD8+ cells transduced with a PD1-CD28 fusion protein are protected from PD-1-mediated inhibition. now investigated potential protein-transduced CD4+ alone or in combination for immunotherapy pancreatic cancer non-Hodgkin lymphoma. Methods: OVA-specific were...
Focal therapy (FT) of the prostate for low risk cancer (PCa) is an alternative to traditional definite treatment options like external beam radiotherapy or radical prostatectomy. However, follow up after FT still challenging and subject current studies. Significance imaging such as multiparametric MRI (mpMRI) currently not well established. In this study, we aimed evaluate efficacy during PCa treated with focal HIFU using CEUS image fusion.Retrospective single arm study in patients uni-...
Toll-like receptor 7 (TLR7) agonists are potent immune stimulants able to overcome cancer-associated suppression. Due dose-limiting systemic toxicities, only the topically applied TLR7 agonist (imiquimod) has been approved for therapy of skin tumors. There is a need TLR7-activating compounds with equivalent efficacy but less toxicity. SC1, novel small molecule TLR7, type-1 interferon inducer, comparable reference resiquimod, yet lower induction proinflammatory cytokines. In vivo, SC1...
Abstract Background Suspicion of testicular torsion represents a urological emergency, necessitating immediate surgery. Comprehensive data on the current trends and perioperative outcomes regarding surgical exploration are sparse. Therefore, we utilized nationwide prevalence results this surgery, aiming to provide evidence matter. Methods We assessed GeRmAn Nationwide inpatient Data (GRAND) from 2005 2021, provided by Research Center Federal Bureau Statistics. performed multiple regression...
Abstract We aimed to provide evidence on the trends and in-hospital outcomes of patients with low- high-flow priapism through largest study in field. used GeRmAn Nationwide inpatient Data (GRAND), provided by Research Center Federal Bureau Statistics (2008-2021), performed multiple patient-level analyses. included 6,588 men low-flow 729 priapism. Among priapism, 156 (2.4%) suffered from sickle cell disease, 1,477 (22.4%) required shunt surgery. Of them, only 37 (2.5%) received a concomitant...
The aim of this study was to assess the security, value, and efficacy second-generation AdVance male sling XP (Boston Scientific®), after implementation in 2010 with advantageous modifications structure needle shape, a prospective multicenter long-term follow-up study.In total, 115 patients were included. Exclusion criteria earlier incontinence (UI) surgery, nocturnal UI, former radiotherapy, or night-time incontinence. We also excluded functional urethra <1 cm preoperatively performed...
Prostate cancer bone metastasis is still one of the most fatal diagnoses for men. Survival circulating prostate tumor cells and their adaptation strategy to survive in niche key point determining early stages. The promoter SFRP2 gene, encoding a WNT signaling modulator, hypermethylated many types including cancer. Moreover, can positively regulate osteogenic differentiation vitro vivo. Here, we showed overexpression cell line PC3 induces an epithelial mesenchymal transition (EMT), increases...
We aimed to evaluate whether PIRADS 3 lesions in multiparametric MRI (mpMRI) represent a significant risk of prostate cancer (PCa) real-world setting different referring radiologic institutes.Between May 2015 and October 2017, total 408 patients were referred our clinic for MRI-ultrasound fusion targeted biopsy the (FusPbx) due suspected cancer. In all patients, preoperatively an mpMRI was performed by altogether 62 institutes. Prostate classified according system. A lesion diagnosed 41...
Introduction of robot-assisted radical prostatectomy (RARP) has revolutionized the therapeutic landscape organ-confined prostate cancer (PCa). However, comparative analyses focused on health-related quality life (HRQOL) after RARP and open retropubic (ORP) are sparse. In current retrospective analysis,inclusion criteria encompassed PSA ≤ 10 ng/ml, pT2c, ISUP 3, age 65 years, preoperative continence. A propensity score-matched patient cohort [n = 418 (ORP: 209, RARP: 209)] was created HRQOL...