A5065018159- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- Coronary Interventions and Diagnostics
- Hormonal and reproductive studies
- Cardiovascular Disease and Adiposity
- Immunotherapy and Immune Responses
- Peripheral Artery Disease Management
- Aortic Thrombus and Embolism
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Lipoproteins and Cardiovascular Health
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- DNA Repair Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Radiopharmaceutical Chemistry and Applications
KU Leuven
2023-2025
Hector-Stiftung
2022-2025
Universitair Ziekenhuis Leuven
2024-2025
Hasselt University
2021
De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown.
Agatston score, the degree of lumen narrowing categorized by CAD-RADS, high-risk atherosclerotic plaque features and pericoronary adipose tissue attenuation (PCAT) are parameters, which can be assessed non-invasively coronary computed tomography angiography (CCTA) aid risk stratification in patients with chronic syndromes (CCS). However, few studies have so far compared prognostic value all those parameters together. To develop test a composite CCTA derived from plaques PCAT undergoing due...
394 Background: High-risk prostate cancer (PCa) patients have a high risk of biochemical recurrence (BCR) and metastatic progression following local therapy. The ARNEO trial is double-blind, placebo-controlled trial, evaluating the role neoadjuvant degarelix with or without apalutamide before radical prostatectomy (RP) in men high-risk PCa. Previously, we demonstrated that receiving + (n=45) had significantly better pathological response terms pT2 disease (51% vs. 27%; p=0.022) minimal...
Abstract Introduction: The prostate cancer tumor microenvironment (TME) contains various cell type identities. We recently described club-like epithelial cells as a constitutive part of the TME present in tissue regions with increased myeloid-derived suppressor infiltration. origin, exact function, and identity remain unresolved. Methods: Here we used bulk, single-cell, spatial transcriptomics to characterize their relation towards androgen deprivation therapy. additionally analyzed...
Abstract Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated mechanisms through which cells escape treatment, but their relation toward tumor microenvironment (TME) remains elusive. Here we present comprehensive landscape of prostate TME at multiple points in standard timeline employing single-cell RNA-sequencing spatial transcriptomics data from 120 patients. We identify club-like as key epithelial...
Background: Coronary computed tomography angiography (CCTA) provides non-invasive quantitative assessments of plaque burden and composition. The assessment components requires the use analysis software that reproducible semi-automated detection analysis. However, commercially available can vary widely in degree automation, resulting differences terms reproducibility time spent. Aim: To compare spent two CCTA tools using different algorithms for coronary volumes composition independent...
The androgen receptor signaling inhibitor apalutamide is used successfully for the treatment of prostate cancer. An increased risk hypothyroidism, mostly subclinical, has been reported in SPARTAN and TITAN trials. We present three cases subacute deterioration previously known but well-controlled hypothyroidism treated with levothyroxine, occurring shortly after initiation apalutamide, resulting severe hypothyroidism. These highlight importance awareness thyroid dysfunction during...
Here, we present a patient with coronary artery disease and prior percutaneous interventions. This had to discontinue taking multiple statins ezetimibe due intolerance musculoskeletal complaints nausea. Monotherapy bempedoic acid was well tolerated exceptionally effective at lipid lowering, enabling patients achieve the low-density lipoprotein target of <55 mg/dl, as recommended by current guidelines. In addition, serial computed tomography angiography performed upon clinical indications,...
Abstract Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated mechanisms through which cells escape treatment, but their relation toward tumor microenvironment (TME) remains elusive. Here we present comprehensive landscape of prostate TME at multiple points in standard timeline employing single-cell RNA-sequencing spatial transcriptomics data from 110 patients. We identify club-like as key epithelial...
You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) I (PD01)1 May 2024PD01-07 NATURAL HISTORY OF PN1 PROSTATE CANCER AFTER RADICAL PROSTATECTOMY: COMPETING RISK ANALYSIS FROM A LARGE MULTI-INSTITUTIONAL SERIES Daimantas Milonas, Kaunas Lithuania, Alexander Giesen, Lorenzo Tosco, Annouschka Laenen, Zilvinas Venclovas, Gaëtan Devos, Alberto Briganti, Paolo Gontero, Markus Graefen, Piotr Chlosta, Christian Gratzke, Giansilivio Marchioro, Rafael Sanchez-Salas,...
You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV (PD61)1 May 2024PD61-05 ONCOLOGICAL OUTCOMES OF NEOADJUVANT DEGARELIX WITH APALUTAMIDE (ARNEO TRIAL) VERSUS STANDARD CARE PRIOR TO RADICAL PROSTATECTOMY FOR HIGH-RISK PROSTATE CANCER: A PROPENSITY SCORE MATCHED ANALYSIS Alexander Giesen, Gaëtan Devos, Lorenzo Tosco, Marcella Baldewijns, Thomas Gevaert, Karolien Goffin, Petit Valentin, Mai Cindy, Raskin Yannic, Van Haute Carl, Lieven Goeman, De Meerleer Gert,...