Michael Valentino

ORCID: 0000-0002-8816-9542
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About
Contact & Profiles
Research Areas
  • Pharmaceutical Practices and Patient Outcomes
  • Regulation of Appetite and Obesity
  • Pharmaceutical Economics and Policy
  • Pharmaceutical studies and practices
  • Pharmacology and Obesity Treatment
  • Primary Care and Health Outcomes
  • Diet and metabolism studies
  • Cardiac Arrhythmias and Treatments
  • Medication Adherence and Compliance
  • Health Systems, Economic Evaluations, Quality of Life
  • Lipoproteins and Cardiovascular Health
  • Neurological and metabolic disorders
  • Combustion and Detonation Processes
  • Cardiac pacing and defibrillation studies
  • Pericarditis and Cardiac Tamponade
  • Healthcare Policy and Management
  • Poisoning and overdose treatments
  • Groundwater and Isotope Geochemistry
  • Liver Disease and Transplantation
  • Cardiac electrophysiology and arrhythmias
  • Water Quality and Resources Studies
  • Organ Transplantation Techniques and Outcomes
  • Cardiac tumors and thrombi
  • Cardiovascular Syncope and Autonomic Disorders
  • Energetic Materials and Combustion

Kean University
2022

Thomas Jefferson University Hospital
2015-2017

Thomas Jefferson University
2009-2016

VA Greater Los Angeles Healthcare System
2016

University of California, Los Angeles
2016

VA Pittsburgh Healthcare System
2007-2016

University of Pittsburgh
2016

Men's Health Forum
2015

Jefferson University Hospitals
2013

United States Air Force Research Laboratory
2004

These guidelines outline the recommended processes and techniques for formulary system management describe pharmacist’s responsibilities roles in managing partnership with other health care professionals. also provide assistance to pharmacists

10.2146/ajhp080086 article EN American Journal of Health-System Pharmacy 2008-06-23

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting hormones in response nutrients the gut. Although guanylyl cyclase downstream cGMP essential regulators centrally regulated feeding behavior invertebrates, role this primordial signaling mechanism mammalian has eluded definition. In intestinal epithelial cells, 2C (GUCY2C) is a transmembrane...

10.1172/jci57925 article EN Journal of Clinical Investigation 2011-08-25

The barrier separating mucosal and systemic compartments comprises epithelial cells, annealed by tight junctions, limiting permeability. GUCY2C recently emerged as an intestinal tumor suppressor coordinating AKT1-dependent crypt-villus homeostasis. Here, the contribution of to integrity opposing colitis tumorigenesis is defined. Mice deficient in (Gucy2c(-/-)) exhibited hyperpermeability associated with reduced junctional proteins. Conversely, activation mice permeability increased Further,...

10.1371/journal.pone.0031686 article EN cc-by PLoS ONE 2012-02-22

Abstract We describe, in rheumatoid arthritis (RA), abnormalities the expression and distribution of heat shock protein (hsp) dendritic cells (DCs) that are conducive to cross-priming DC cross-talk. As detected by ELISA, inducible (i)hsp70 was dramatically increased RA synovial fluid (RASF) vs normal human sera osteoarthritis gout fluid. Immunoblot analysis fresh RASF revealed marked increases ihsp70 activation its transcription factor factor-1, compared with peripheral blood cells. Flow...

10.4049/jimmunol.171.11.5736 article EN The Journal of Immunology 2003-12-01

Obesity has emerged as one of the principal worldwide health concerns modern era, and there exists a tremendous unmet clinical need for safe effective therapies to combat this global pandemic. The prevalence obesity its associated comorbidities, including cardiovascular metabolic diseases, focused attention those in drug discovery development on generating modalities treatment prevention obesity. Early efforts field pharmacotherapy centered agents with indeterminate mechanisms action. This...

10.1038/clpt.2010.57 article EN Clinical Pharmacology & Therapeutics 2010-05-05

The packaging of specific mRNAs into ribonucleoprotein granules called germ is required for germline proliferation and maintenance. During Drosophila granule development, such as nanos (nos) polar component (pgc) localize to through a stochastic seeding self-recruitment process that generates homotypic clusters: aggregates containing multiple copies transcript. Germ vary in mRNA composition with respect the different transcripts they contain their quantity. However, what influences during...

10.1016/j.bpj.2022.03.014 article EN cc-by-nc-nd Biophysical Journal 2022-03-12

The Veterans Health Administration (VHA) runs the largest integrated healthcare system in nation. Formulary management within VHA primarily involves 3 national groups: Medical Advisory Panel, Integrated Service Network Leaders, and Pharmacy Benefits Management Strategic Healthcare Group. Together, these groups manage drug formulary with a goal of providing comprehensive, safe, cost-effective pharmacy benefit for veterans. Traditionally, has relied on cost-minimization analyses decisions....

10.1097/01.mlr.0000170004.17480.49 article EN Medical Care 2005-06-22

10.1016/j.jccase.2016.12.010 article EN publisher-specific-oa Journal of Cardiology Cases 2017-03-07

The Land‐Sea Interface (LSI) is a region of particular importance to human endeavor. includes the exposed outer coast, coastal waters, bays, estuaries, and deltas. Its area small in comparison with that adjacent open ocean or land, but LSI at once high biological productivity complexity portion most heavily impacted by activities. also has profound effect on transport materials between land sea. Chemically reactive transported from sea undergo intense biogeochemical cycling net...

10.1029/88eo01101 article EN Eos 1988-09-06

A 56-year-old woman with cirrhosis due to chronic hepatitis C underwent emergent transjugular intrahepatic portosystemic shunt (TIPS) a ruptured esophageal varix during esophagogastroduodenoscopy. Following TIPS, the patient experienced rapid rise in serum bilirubin no evidence of biliary obstruction or hepatic injury. She was determined have bilhemia, rare but serious complication TIPS.

10.14309/crj.2015.101 article EN cc-by-nc-nd ACG Case Reports Journal 2015-10-14
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