A5091457947- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Advancements in Transdermal Drug Delivery
- Allergic Rhinitis and Sensitization
- Advanced Drug Delivery Systems
- Plant Reproductive Biology
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Synthesis of heterocyclic compounds
- Ocular Surface and Contact Lens
- Phenothiazines and Benzothiazines Synthesis and Activities
- Circadian rhythm and melatonin
- COVID-19 Clinical Research Studies
- Proteins in Food Systems
- SARS-CoV-2 and COVID-19 Research
- Psoriasis: Treatment and Pathogenesis
- Polysaccharides and Plant Cell Walls
- Synthesis and Biological Evaluation
- Skin and Cellular Biology Research
Freie Universität Berlin
2018-2023
Humboldt-Universität zu Berlin
2022
Charité - Universitätsmedizin Berlin
2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022
Institute of Pharmacology
2018
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in alveolar compartment is strictly ACE2-dependent and to what extent virus-induced tissue damage and/or direct immune activation determines early pathogenesis still elusive.Spectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 "gain-of-function" experiments were applied infected human lung...
Due to the low cutaneous bioavailability of tacrolimus (TAC), penetration enhancers are used improve its into skin. However, poor loading capacity, non-biodegradability, toxicity, and in some cases inefficient skin challenging issues that hamper their applications for dermal TAC delivery. Here we present poly(lactide-co-glycerol) (PLG) as a water soluble, biodegradable, biocompatible TAC-carrier with high capacity (14.5% w/w TAC) drug delivery efficiencies PLG was synthesized by cationic...
Abstract Mucosal surfaces pose a challenging environment for efficient drug delivery. Various delivery strategies such as nanoparticles have been employed so far; yet, still yielding limited success. To address the need of transmucosal delivery, this report presents synthesis novel disulfide‐containing dendritic polyglycerol (dPG)‐based nanogels and their preclinical testing. A bifunctional linker is coupled to dPG act macromolecular crosslinker poly‐ N ‐isopropylacrylamide (PNIPAM)...
Polymeric nanogels are promising nonirritating nanocarriers for topical delivery applications. However, conventional hydrophilic networks limit encapsulation of hydrophobic therapeutics and hinder tailored interactions with the amphiphilic skin barrier. To address these limitations, we present containing domains. Two competing factors determine favorable nanogel–skin need to be balanced through network composition: suitable surface hydrophobicity low rigidity (through physical cross-links)....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analog the GABA agonist THIPRene Nordmann, Patrick Graff, Richard Maurer, Beat H. GaehwilerCite this: J. Med. Chem. 1985, 28, 8, 1109–1111Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August...
Human skin equivalents emerged as novel tools in preclinical dermatological research. It is being claimed that they may bridge the translational gap between and clinical research, yet only a few studies have investigated their suitability for drug testing so far. Therefore, we if inflammatory equivalents, which emulate hallmarks of atopic dermatitis (AD), are suitable to assess anti-inflammatory effects dexamethasone (DXM) cream formulation or loaded onto dendritic core-multishell...
Abstract The development of atopic dermatitis (AD) in infancy, and subsequent allergic rhinitis, food allergies, asthma later childhood, is known as the march. mechanism largely unknown, yet course disease indicates contribution inter-epithelial crosstalk, through to onset inflammation skin progression another mucosal epithelium. Here, we investigated if how skin-lung epithelial crosstalk could contribute First, emulated this indirect co-culture bioengineered atopic-like models...