A5034387013- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Spondyloarthritis Studies and Treatments
- Dermatologic Treatments and Research
- COVID-19 Clinical Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Pelvic floor disorders treatments
- Acute Lymphoblastic Leukemia research
- Skin Diseases and Diabetes
- Dermatological and Skeletal Disorders
- Eosinophilic Esophagitis
- Connective Tissue Growth Factor Research
- Bone and Joint Diseases
- Infectious Diseases and Tuberculosis
- Enhanced Recovery After Surgery
- Oral Health Pathology and Treatment
- Uterine Myomas and Treatments
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Medical Imaging and Pathology Studies
- COVID-19 and healthcare impacts
Post Graduate Institute of Medical Education and Research
2016-2025
Panjab University
2024
Framingham State University
2022
Jaypee University of Engineering and Technology
2014-2022
Dr. B. R. Ambedkar National Institute of Technology Jalandhar
2021
Center for Rheumatology
2019-2021
Institute of Post Graduate Medical Education and Research
2016-2021
Cooper University Health Care
2021
Spectrum Health
2020-2021
Cooper Medical School of Rowan University
2021
Poncet's disease is a well recognized form of reactive arthritis in the presence extra-articular tuberculosis. There are very limited case reports even from countries where tuberculosis common and there no accepted diagnostic criteria for disease. In present study we describing clinical features tuberculosis-endemic region along with proposal new criteria.All patients diagnosed as having were included. The details, demographic features, pattern joint involvement, investigation findings,...
Abstract Aim To evaluate efficacy of sulfasalazine for axial ankylosing spondylosis. Methods 67 patients fulfilling the inclusion criteria were included and randomized into treatment placebo group. Results Mean age in group was 31 years (range: 17–60); 30 (18–46). disease duration 8.4 3–25) 8.3 (3–19). Clinically significant improvement ASDAS (ΔASDAS > 1.1) seen 15.1% 67.7% ( P = 0.001). The mean ± SD ΔASDAS 1.33 0.38 0.9–2.3) where as it 0.748 0.23 (0.4–1.3) with difference 0.00)....
Agricultural soils can be a source or sink for atmospheric CO2 depending upon the management practices and land use patterns. Progressive increase in concentration of GHGs since industrial era has created worldwide interest identifying strategies to reduce these gases atmosphere. Carbon sequestration is an important technology maintenance optimum level atmosphere, which in-turn results reducing recent atmosphericcarbon dioxide, contributing global warming. stored soilsis 2–4 times more as...
Risk of subclinical atherosclerosis is increased in patients with systemic lupus erythematosus (SLE). We correlated carotid intima media thickness (CIMT) and endothelial dysfunction through flow-mediated dilation (FMD) SLE the Disease Activity Index (SLEDAI).This single-centre cross-sectional study recruited 100 consenting outpatients (ACR 1997 criteria) out which 50 had nephritis, disease duration ≥2 years for ≥6 months nephritis. measured baseline laboratory levels, CIMT FMD (after...
The evolutionary trajectories of species with separate sexes depend on the effects genetic variation female and male traits as well direction alignment selection between sexes. Classical theory has shown that evolution is equally responsive to females males, natural increasing product average relative fitness each sex over time. This simple rule underlies several important predictions regarding maintenance variation, basis adaptation, dynamics "sexually antagonistic" alleles. Nevertheless,...
Abstract Aim: Currently, therapy for interstitial lung disease in patients with systemic sclerosis is unsatisfactory. A prospective open label study was conducted a North Indian tertiary Institute to assess the efficacy of intermittent pulse cyclophosphamide (CYC) and high‐dose prednisolone (SSc)‐related (ILD). Methods: Consecutive SSc ILD, diagnosed on spirometry, carbon monoxide diffusing capacity (DLCO) high‐resolution computed tomography (HRCT) scan were treated. Pulmonary function tests...
Abstract Background Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose unclear, varying from 15 to 25 mg every 6-h. Methods Open-label RCT included patients (≤ 50 mg/week) methotrexate defined as WBC ≤ 2 × 10^9/L or platelet and randomized them receive either usual (15 mg) high-dose (25 intravenous leucovorin given Primary outcome was mortality at 30-days secondary outcomes were hematological recovery mucositis recovery....
It is unclear whether erythrocyte methotrexate polyglutamate levels (MTX-glun) are associated with response or adverse effects to in rheumatoid arthritis. This preliminary study evaluated their utility Asian Indian patients over 24 weeks.Rheumatoid arthritis were started on oral at a dose of 15 mg/wk, which was escalated 25 mg by 12 weeks and continued till weeks. Erythrocyte (RBC) MTX-glu1 MTX-glu5 (nmol/L RBC) determined 4, 8, 16, using reverse-phase high-performance liquid chromatography....
Abstract Background Ovarian toxicity is a dreaded complication of cyclophosphamide (CYC). With the use lower cumulative doses intravenous CYC (modified NIH regimens) and availability better markers ovarian toxicity, incidence dysfunction needs reassessment. Lupus disease activity, by itself, also believed to affect function negatively. Methods This single-centre prospective cohort study recruited 50 female patients severe lupus aged 18–40 years. Twenty-five each received induction with...
Antisynthetase syndrome is characterized by a triad of myositis, arthritis, and interstitial lung disease. Anti-Jo-1 the most common associated autoantibody. This study planned to look at presentation anti-Jo-1 antisynthetase in single Indian center.This was medical records review single-center that included patients with over 10 years.This 27 syndrome, mean age 40 ± 9.2 years female preponderance (female-to-male ratio, 4:1). At presentation, characteristic present only 4 patients. A...
To assess the prevalence of secondary Sjögren's syndrome (sSS) and its association with joint damage in patients rheumatoid arthritis (RA) from northern India.Patients included had RA, fulfilling 1987 American College Rheumatology criteria, disease duration more than 1 year. They were administered a sicca questionnaire that six questions subjective criteria European Consensus Group (AECG) criteria. Those who answered affirmatively to at least one question underwent Schirmer I test (ocular...
Antinuclear antibody (ANA) pattern and autoantibody (autoAb) profiling of 150 adult systemic sclerosis (SSc) patients concerning their clinical association diagnostic significance were analyzed by indirect immunofluorescence (IIF), immunoblot, fluorescence enzyme immunoassay. One hundred forty-three (95.3%) had positive ANA: DNA topoisomerase I (topo I)-like pattern-84(56%); speckled pattern-44(29.3%);centromere pattern-7(4.6%); nucleolar pattern-4(2.6%). Three distinct topo I-like patterns...
Introduction: Systemic Sclerosis is known to involve the gastrointestinal system and can lead multitude of problems predominantly affecting GI motility. Methods: It was a prospective, observational, single centre study fifty consecutive patients with SSc who presented rheumatology clinic. Gut score assessed using UCLA SCTC GIT 2.0 questionnaire. 35 underwent esophago- gastro duodenoscopy(UGIE), 31 esophageal manometry, 37 lactulose breath test assess orocaecal transit time (OCTT) glucose for...