A5082642357- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Tuberous Sclerosis Complex Research
- Macrophage Migration Inhibitory Factor
- Advanced Fluorescence Microscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- ATP Synthase and ATPases Research
- Neuroscience of respiration and sleep
- Nutrition and Health Studies
- Anesthesia and Sedative Agents
- Maternal Mental Health During Pregnancy and Postpartum
Polish Academy of Sciences
2011-2024
Maj Institute of Pharmacology
2011-2024
Jagiellonian University
2009-2023
Obesity in humans is associated with cognitive decline and elevated risk of neurodegenerative diseases old age. Variations high-fat diet are often used to model these effects animal studies. However, we previously reported improvements markers memory learning, as well larger hippocampi higher metabolite concentrations Wistar rats fed high-fat, high-carbohydrate (HFCD, 60 % energy from fat, 28 carbohydrates) for 1 year; this leads mild ketonemia (Setkowicz et al. PLoS One 10:e0139987, 2015)....
Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are commonly prescribed to women during pregnancy and breastfeeding despite posing a risk of adverse cognitive outcomes affective disorders for the child. The consequences SSRI-induced excess 5-HT development brain neuromodulatory system remain largely unexplored. In this study, an SSRI - fluoxetine (FLX) was administered C57BL/6 J mouse dams lactation assess its effects on offspring. We found that maternal FLX decreased field...
Abstract Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are a class of antidepressant drugs commonly prescribed to women during pregnancy and breastfeeding treat depression. There is evidence that prenatal exposure SSRIs may be associated with higher risk adverse cognitive outcomes affective disorders in later life. In animal models, brain development results behavioral alterations as well structural abnormalities cerebral cortical neurons. Little known about the consequences SSRI-...
For social interaction to be successful, two conditions must met: the motivation initiate it and ability maintain it. This study uses both optogenetic chemogenetic approaches reveal specific neural pathways that selectively influence those components.
Abstract Preclinical studies strongly suggest that cocaine seeking depends on the neuronal activity of ventral tegmental area (VTA) and phasic dopaminergic (DA) signaling. Notably, VTA pharmacological inactivation or dopamine receptor blockade in forebrain may induce behavioral inhibition general acute aversive states particular, thus reducing indirectly. Such artifacts hinder successful translation these findings clinical practice. Here, we aimed to evaluate if dynamic manipulations...
Abstract Phasic dopamine (DA) release from the ventral tegmental area (VTA) into forebrain structures is implicated in associative learning and conditional stimulus (CS)‐evoked behavioral responses. Mounting evidence points to noradrenaline signaling VTA as an important regulatory input. Accordingly, adrenergic receptor (AR) blockade has been shown modulate CS‐dependent behaviors. Here, we hypothesized that α 1 ‐ 2 ‐AR (but not β‐AR) activity preferentially modulates phasic, contrast tonic,...
Activity of the alpha1-adrenergic receptor (α1-AR) in ventral tegmental area (VTA) modulates dopaminergic activity, implying its modulatory role behavioral functions dopamine (DA) system. Indeed, intra-VTA α1-AR blockade attenuates conditioned stimulus dependent behaviors such as drug seeking responses signifying a noradrenergic signaling VTA behaviors. Importantly, activity Pavlovian associative learning with positive outcomes remains unknown. Here, we aimed to examine how affects...
Malformations of cortical development, such as focal dysplasia, are commonly associated with intractable epilepsy. Multiple animal models were created in attempts to recapitulate features human malformations development. These manipulations give rise various or diffuse anatomical abnormalities, accompanied by altered susceptibility epileptic seizures. Both humans and the question timing initiating insult is important.Here, we used a rat model cerebral dysplasia elicited prenatal irradiation...
Noradrenergic neurotransmission is a critical mediator of stress responses. In turn, exposure to induces noradrenergic system adaptations, some which are implicated in the etiology stress-related disorders. Adrenergic receptors (ARs) ventral tegmental area (VTA) have been demonstrated regulate phasic dopamine (DA) release forebrain, necessary for behavioral responses conditional cues. However, impact on modulation VTA has not previously explored. We demonstrate that ARs dopaminergic activity...
Background : The study examined the effects of 5-HT 7 receptor activation on GABAergic transmission within dentate gyrus and plasticity at glutamatergic perforant path input. Methods Immunofluorescence imaging was performed using transverse hippocampal slices from transgenic mice expressing GFP under Htr7 promoter. This followed by whole-cell patch clamp electrophysiological recordings spontaneous inhibitory postsynaptic currents recorded granule cells hilar mossy — two neuron types present...
Abstract Background The study examined the effects of 5-HT 7 receptor activation on GABAergic transmission within dentate gyrus and plasticity at glutamatergic perforant path input. Methods Immunofluorescence imaging was performed using transverse hippocampal slices from transgenic mice expressing green fluorescent protein (GFP) under Htr7 promoter. This followed by whole-cell patch clamp electrophysiological recordings assessing pharmacologically activating receptors spontaneous inhibitory...
ABSTRACT Malformations of cortical development (MCD) are a common cause intractable seizures in humans. Among these, focal dysplasia (FCD) poses an outstanding challenge. There several subtypes FCD that show significant variation pathology and clinical presentation. All types exhibit disturbed cytoarchitecture increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically genes related to mammalian target rapamycin (mTOR), identified only subset cases. A...
Substance use disorder is linked to impairments in the ventral tegmental area (VTA) dopamine (DA) reward system. Noradrenergic (NA) inputs from locus coeruleus (LC) into VTA have been shown modulate neuronal activity, and are implicated psychostimulant effects. Phasic LC activity controls time- context-sensitive processes: decision making, cognitive flexibility, motivation attention. However, it not yet known how such temporally-distinct contributes cocaine seeking. In a previous study we...
Abstract Drug seeking is associated with the ventral tegmental area (VTA) dopaminergic (DA) activity. Previously, we have shown that brief optogenetic inhibition of VTA DA neurons 1 s pulses delivered every 9 attenuates cocaine under extinction conditions in rats without producing overt signs dysphoria or locomotor sedation. Whether recruitment neuronal pathways inhibiting activity would suppress drug remains unknown. Here, asked if stimulation lateral habenula (LHb) efferents rostromedial...
Disturbances of the early stages neurogenesis lead to irreversible changes in structure mature brain and its functional impairment, including increased excitability, which may be basis for drug-resistant epilepsy. The range possible clinical symptoms is as wide different disturbed be. In this study, we used a quadruple model dysplasia by comparing structural disorders animals whose was with single dose 1 Gy gamma rays at one four neurogenesis, that is, on days 13, 15, 17, or 19 prenatal...