A5004804122- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Treatment of Major Depression
- Epilepsy research and treatment
- Neural dynamics and brain function
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience of respiration and sleep
- Diet and metabolism studies
- Maternal Mental Health During Pregnancy and Postpartum
- Neuropeptides and Animal Physiology
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neural Engineering
- ATP Synthase and ATPases Research
- Birth, Development, and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Adenosine and Purinergic Signaling
- Pharmacological Effects and Toxicity Studies
Polish Academy of Sciences
2015-2024
Maj Institute of Pharmacology
2013-2024
Jagiellonian University
2017
Institute of Pharmacology
2016
Early life experiences are crucial factors that shape brain development and function due to their ability induce structural functional plasticity. Among these experiences, early-life stress (ELS) is known interfere with maturation, increasing the risk of future psychopathologies, including depression, anxiety, personality disorders. Moreover, ELS may contribute emergence psychopathologies during adolescence. In this present study, we investigated effects ELS, in form maternal separation...
Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are commonly prescribed to women during pregnancy and breastfeeding despite posing a risk of adverse cognitive outcomes affective disorders for the child. The consequences SSRI-induced excess 5-HT development brain neuromodulatory system remain largely unexplored. In this study, an SSRI - fluoxetine (FLX) was administered C57BL/6 J mouse dams lactation assess its effects on offspring. We found that maternal FLX decreased field...
(S)-Ketamine is the first rapid-acting antidepressant drug (RAAD) introduced for treatment of depression. However, research still being carried out on search further RAADs that will be not only effective but also safe to use. Recent data have indicated combined administration (R)-ketamine and mGlu2/3 receptor antagonist LY341495 (mixRL) induces rapid sustained effects in chronic unpredictable mild stress (CUMS) model depression mice, use this combination associated with a low risk...
The data concerning antipsychotic-like activity of negative allosteric modulators/antagonists mGlu7 receptors are limited. only available ligands for this receptor MMPIP and ADX71743. In the present studies we used stable cell line expressing it was shown that both compounds dose dependently potentiated forskolin elevated cAMP concentration in T-REx 293 cells, showing their inverse agonist properties. Subsequently, pharmacokinetic were performed. Both given i.p at 10 mg/kg. reached Cmax...
Abstract Plasticity of the brain’s dopamine system plays a crucial role in adaptive behavior by regulating appetitive motivation and control reinforcement learning. In this study, we investigated drug- natural-reward conditioned behaviors mouse model which NMDA receptor-dependent plasticity dopaminoceptive neurons was disrupted. We generated transgenic line with inducible selective inactivation NR1 subunit expressing D1 receptors (the D1CreERT2 mice). Whole-cell recordings spontaneous EPSCs...
Abstract Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are a class of antidepressant drugs commonly prescribed to women during pregnancy and breastfeeding treat depression. There is evidence that prenatal exposure SSRIs may be associated with higher risk adverse cognitive outcomes affective disorders in later life. In animal models, brain development results behavioral alterations as well structural abnormalities cerebral cortical neurons. Little known about the consequences SSRI-...
The use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase risk affective disorders cognitive symptoms progeny. In animal models, maternal exposure to throughout gestation lactation negatively affects behavior offspring. Little is known about effects on synaptic transmission plasticity offspring cerebral cortex. During C57BL/6J mouse dams received (7.5 mg/kg/day) with drinking water. Female mice intraperitoneal...
The effects of prenatal stress procedure were investigated in 3 months old male rats. Prenatally stressed rats showed depressive-like behavior the forced swim test, including increased immobility, decreased mobility and climbing. In ex vivo frontal cortex slices originating from prenatally animals, amplitude extracellular field potentials (FPs) recorded cortical layer II/III was larger, mean ratio pharmacologically-isolated NMDA to AMPA/kainate component potential—smaller than control...
The role that thyroid hormone deficiency plays in depression and synaptic plasticity adults has only begun to be elucidated. This paper analyzes the possible link between hypothyroidism cognitive function alterations, using Wistar–Kyoto (WKY—an animal model of depression) rats control Wistar under standard conditions (propylthiouracil administration—PTU). A weakening memory processes WKY is shown behaviorally, reduction long-term potentiation (LTP) dentate gyrus (DG) CA1 hippocampal regions....
This study demonstrates how exposure to psychosocial crowding stress (CS) for 3, 7, and 14 days affects glutamate synapse functioning signal transduction in the frontal cortex (FC) of rats. CS effects on synaptic activity were evaluated FC slices primary motor (M1) by measuring field potential (FP) amplitude, paired-pulse ratio (PPR), long-term potentiation (LTP). Protein expression GluA1, GluN2B mGluR1a/5, VGLUT1, VGLUT2 was assessed western blot. The body's response body weight plasma...