A5020175256- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Treatment of Major Depression
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Electroconvulsive Therapy Studies
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Nuclear Receptors and Signaling
- Conducting polymers and applications
- Pharmacological Receptor Mechanisms and Effects
- Cannabis and Cannabinoid Research
- Neurological disorders and treatments
- Amino Acid Enzymes and Metabolism
- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Organic Chemistry Cycloaddition Reactions
- Eicosanoids and Hypertension Pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Chemical Reaction Mechanisms
- Bone and Dental Protein Studies
- Fluoride Effects and Removal
- Chemical Reactions and Mechanisms
Polish Academy of Sciences
2015-2024
Maj Institute of Pharmacology
2015-2024
Institute of Pharmacology
2009-2015
Karolinska University Hospital
2011
Karolinska Institutet
2011
Niepubliczna Wyższa Szkoła Medyczna
1990
Animal models are widely used to study antidepressant-like effect in rodents. However, it should be mentioned that pharmacological do not always take into account the complexity of disease process. In present paper, we demonstrated repeated but acute treatment with a low dose reserpine (0.2 mg/kg i.p.) led model depression which was based on its inhibitory vesicular monoamine transporter 2, and monoamines depleting action brain. fact, observed chronic induced distinct depressive-like...
Cannabinoid receptors 1 (CB1) and/or 2 (CB2) are overexpressed in many types of human malignancies including mantle cell lymphoma (MCL). Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38–mitogen-activated protein kinase-dependent activation caspase-3 apoptotic death most MCLs. However, this report we describe that some MCLs the response treatment with cannabinoids decreased viability as assessed by metabolic activity but did not involve cascade or loss plasma membrane...
1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), unlike several other tetrahydroisoquinolines, displays neuroprotective properties. To elucidate this action we compared the effects of 1MeTIQ with 1,2,3,4-tetrahydroisoquinoline (TIQ), a compound sharing many activities (among them reducing free radicals formed during dopamine catabolism), but offering no clear neuroprotection. We found that compounds similarly inhibit free-radical generation in an abiotic system, as well indices...
Chronic pain is a major health problem that affects significant number of patients, resulting in personal suffering and substantial care costs. One the most commonly reported causal conditions osteoarthritis (OA). In addition to sensory symptoms, chronic shares an inherent overlap with mood or anxiety disorders. The involvement frontal cortex, striatum nucleus accumbens, affective processing still poorly understood. Male Wistar rats were divided into two groups: MIA (monoiodoacetate injected...
The data concerning antipsychotic-like activity of negative allosteric modulators/antagonists mGlu7 receptors are limited. only available ligands for this receptor MMPIP and ADX71743. In the present studies we used stable cell line expressing it was shown that both compounds dose dependently potentiated forskolin elevated cAMP concentration in T-REx 293 cells, showing their inverse agonist properties. Subsequently, pharmacokinetic were performed. Both given i.p at 10 mg/kg. reached Cmax...
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), an endogenous compound present in the brain, was suspected of participation etiopathogenesis Parkinson's disease, most common serious movement disorder worldwide. In this study, we evaluated effect different (50, 100, and 500 µM) concentrations salsolinol on markers glutamate-induced apoptotic neurotoxic cell damage, such as caspase-3 activity, lactate dehydrogenase (LDH) release, loss mitochondrial membrane potential....
Disturbances caused by excess or shortages of certain elements can affect the cerebral reward system and may therefore modulate processes associated with development dependence as was confirmed behavioural studies on animals addicted to morphine. Earlier publications demonstrated proved neurodegenerative properties both low high doses fluoride ions in animal experiments epidemiological clinical studies. The aim conducted course present study analyse effect pre- postnatal exposure 50 ppm F−...
Oxidative stress is a major contributing factor in range of brain pathologies and the etiology depression. 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) an endogenous substance which present mammalian exhibits neuroprotective, monoamine oxidase (MAO)-inhibiting properties. In study, order to investigate potential role 1MeTIQ as antidepressant, we tested antidepressant-like effects comparison with desipramine (a classic antidepressant) forced swimming test (FST), using HPLC methodology,...
Schizophrenia is a mental illness which characterised by positive and negative symptoms cognitive impairments. While the major prevailing hypothesis that altered dopaminergic and/or glutamatergic transmission contributes to this disease, there evidence noradrenergic system also plays role in its symptoms.In present paper, we investigated pro-cognitive effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) an endogenous neuroprotective compound, on ketamine-modelled schizophrenia rats.We...
Abstract Background The aim of the present study was to evaluate effect 1MeTIQ on fear memory and social interaction in an MK-801-induced model schizophrenia. results obtained after administration were compared with those olanzapine, antipsychotic drug. Methods Sprague–Dawley rats received a single injection MK-801 induce behavioral disorders. given either acutely dose or chronically for 7 consecutive days. Olanzapine administered once. In groups receiving combined treatments, olanzapine 20...
Biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders especially depression. Animal models are widely used to study antidepressant-like effect rodents; however, it should be taken into account that pharmacological do not always answer complexity disease processes. This verified behavioral (forced swim test (FST), locomotor activity test) neurochemical effects (monoamines metabolism) low dose clonidine (0.1 mg/kg i.p.)...