A5061387141- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Schizophrenia research and treatment
- Chemical synthesis and alkaloids
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Estrogen and related hormone effects
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxic Organic Pollutants Impact
- Ion channel regulation and function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Birth, Development, and Health
- Nerve injury and regeneration
Maj Institute of Pharmacology
2015-2025
Polish Academy of Sciences
2015-2025
Institute of Pharmacology
2021
Jagiellonian University
2021
Eli Lilly (United States)
2002-2004
Indiana University School of Medicine
2002
Indiana University – Purdue University Indianapolis
2002
Instytut Farmaceutyczny
2000
Muskegon Community College
1978
Clinical studies provide evidence that ketamine and psilocybin could be used as fast-acting antidepressants, though their mechanisms toxicity are still not fully understood. To address this issue, we have examined the effect of a single administration on extracellular levels neurotransmitters in rat frontal cortex reticular nucleus thalamus using microdialysis. The genotoxic density glutamate receptor proteins was measured with comet assay Western blot, respectively. An open field test,...
Abstract Clinical studies have suggested that early‐life stress (ELS) increases the risk of psychopathologies are strongly associated with dysfunction dopaminergic neurotransmission. Thus, ELS may interfere development and maturation system; however, mechanisms involved in such interference poorly understood. In present study, we investigated effect on survival specific populations neurons substantia nigra pars compacta (SNc) ventral tegmental area (VTA) during postnatal development. First,...
Triclocarban is a phenyl ether that has recently been classified as contaminant of emerging concern. Evidence shows triclocarban present in human tissues, but little known about the impact on nervous system, particularly at early developmental stages. This study demonstrated was used environmentally relevant concentrations induced apoptosis mouse embryonic neurons, inhibited sumoylation, and changed epigenetic status, evidenced by impaired activities HDAC, sirtuins, DNMT, global DNA...
The pharmacological activation of the GPR39 receptor has been proposed as a novel strategy for treating seizures; however, this hypothesis not verified experimentally. TC-G 1008 is small molecule agonist increasingly used to study function but validated using gene knockout. Our aim was assess whether produces anti-seizure/anti-epileptogenic effects in vivo and are mediated by GPR39. To obtain goal we utilized various animal models seizures/epileptogenesis knockout mice model. Generally,...
We evaluated the impact of conditioned stress on outflow dopamine in rat prefrontal cortex. Exposure rats to an environment associated with aversive stimuli-foot shock enhanced a similar way as seen during conditioning session when foot shocks were applied. Diazepam (2.5 and 10 mg/kg) dose-dependently decreased and, given dose mg/kg, but not 2.5 evoked by stress. On other hand, ipsapirone (10 buspirone basal dopamine. When exposed stress, stress-evoked elevation was abolished. Ipsapirone...