A5067587745- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Neuroscience and Neuropharmacology Research
- Forensic Toxicology and Drug Analysis
- Chemical synthesis and alkaloids
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Nutrition and Health Studies
- Lipid Membrane Structure and Behavior
- Neuropeptides and Animal Physiology
- Public health and occupational medicine
- Adenosine and Purinergic Signaling
- Metabolomics and Mass Spectrometry Studies
- Pain Mechanisms and Treatments
Polish Academy of Sciences
2018-2025
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2025
Maj Institute of Pharmacology
2018-2023
Clinical studies provide evidence that ketamine and psilocybin could be used as fast-acting antidepressants, though their mechanisms toxicity are still not fully understood. To address this issue, we have examined the effect of a single administration on extracellular levels neurotransmitters in rat frontal cortex reticular nucleus thalamus using microdialysis. The genotoxic density glutamate receptor proteins was measured with comet assay Western blot, respectively. An open field test,...
NBOMes are N-benzylmethoxy derivatives of the 2C family hallucinogens. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is one commonly used illicit drugs. It exhibits high binding affinity for 5-HT2A/C and 5-HT1A serotonin receptors. Activation 5-HT2A receptor induces head-twitch response (HTR) in rodents, a behavioral marker hallucinogen effect humans. There not much data on neurochemical properties NBOMes. Therefore, we aimed to investigate 25I-NBOMe extracellular level...
Abstract S-palmitoylation, a dynamic post-translational modification, has long been suggested to play pivotal role in synaptic plasticity, learning, and memory. However, its precise impact on proteins function remains unclear. In this study, we show that acute protein depalmitoylation the hippocampus differentially affects short- long-term depending synapse type. Strikingly, also reprograms neuronal spiking timing following associative network activation. Our research identifies pre-...
Background and Purpose The concept of opioid ligands biased towards the G protein pathway with minimal recruitment β‐arrestin‐2 is a promising approach for development novel, efficient, potentially nonaddictive therapeutics. A recently discovered μ‐opioid receptor agonist, PZM21, showed analgesic effects reduced side effects. Here, we aimed to further investigate behavioural biochemical properties PZM21. Experiment Approach We evaluated antinociceptive systemic intrathecal PZM21...
Abstract Rationale 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin 5-HT 2A/2C receptor agonist with hallucinogenic activity. There no data on the 25I-NBOMe effect brain neurotransmission and animal performance after chronic administration. Objectives We examined of 7-day treatment (0.3 mg/kg/day) neurotransmitters’ release rats’ behavior in comparison to acute dose. Methods Changes dopamine (DA), (5-HT), acetylcholine (ACh), glutamate were studied...
Abstract 4-Bromo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25B-NBOMe) is a hallucinogen exhibiting high binding affinity for 5-HT 2A/C serotonin receptors. In the present work, we investigated its effect on dopamine (DA), (5-HT), acetylcholine (ACh), and glutamate release in rat frontal cortex, striatum, nucleus accumbens. Hallucinogenic activity, impact cognitive motor functions, anxiogenic/anxiolytic properties of this compound were also tested. The DA, 5-HT, ACh, was studied using...
Pyrovalerone derivatives (α-pyrrolidinophenones) form a distinct branch of synthetic cathinones, popular group novel psychoactive substances, and exert strong psychostimulatory effects resulting from their high potency to inhibit dopamine (DA) norepinephrine transporters, with negligible activity at the serotonin (5-HT) transporter. In contrast old generation α-pyrrolidinophenones, 3,4-MDPV α-PVP, there is limited data on pharmacology toxicology analogs. Therefore, present study assesses in...
Abstract According to the European Drug Report (2016), use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in last years. Studies humans indicate that psychostimulant drug adolescence increases risk abuse adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release synaptic cleft. In animal studies, high repeated doses mephedrone given adolescent but not adult mice or rats induced toxic...
Abstract 4-Iodo-2,5-dimethoxy- N -(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a new psychoactive substance with strong hallucinogenic properties. Our previous data reported increased release of dopamine, serotonin, and glutamate after acute injections tolerance development in the neurotransmitters rats’ behavior chronic treatment 25I-NBOMe. The recreational use 25I-NBOMe associated severe intoxication deaths humans. There no about vivo toxicity towards brain tissue. In this article...
Methcathinone (MC) and 3-fluoromethcathinone (3-FMC) are well-known members of the synthetic cathinone derivatives, second most abused group novel psychoactive substances (NPS). They considered as methamphetamine-like cathinones, they elicit their psychostimulatory effects via inhibition monoamine uptake enhanced release. The present study examines MC 3-FMC on spontaneous locomotor activity mice extracellular levels dopamine serotonin in mouse striatum. Both produced a dose-dependent...
Abstract Background 4-Iodo-2,5-dimethoxy- N -(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin (5-HT) receptor agonist with hallucinogenic properties. The aim of our research was to examine the role 5-HT 2A , 2C and 1A subtypes in 25I-NBOMe activity its effect on dopamine (DA), glutamate release rat frontal cortex. Methods Hallucinogenic investigated using wet dog shake (WDS) test. DA, cortex studied microdialysis freely moving rats. Neurotransmitter levels were analyzed by...
The pathophysiology of depression is related to the reduced volume hippocampus and amygdala hypertrophy nucleus accumbens. mechanism these changes not well understood; however, clinical studies have shown that administration fast-acting antidepressant ketamine reversed decrease in depressed patients, magnitude this effect correlated with reduction depressive symptoms. In present study, we attempted find out whether psychedelic substance psilocybin affects neurotransmission limbic system...
Pathophysiology of depression is related with reduced volume the hippocampus and amygdala hypertrophy nucleus accumbens. The mechanism these changes not well under-stood, but clinical studies have shown that administration fast-acting antidepressant keta-mine reversed decrease in depressed patients, magnitude this effect correlated reduction depressive symptoms. In present study, we attempted to find out whether psychedelic substance psilocybin affects neurotransmission limbic system...
Abstract Purpose 3,4-Methylenedioxypyrovalerone (3,4-MDPV) is a prevalent member of α-pyrrolidinophenones, group new psychoactive substances, known for its strong psychostimulant effect resulting from potent stimulation dopamine (DA) circuitry in the brain. As 3,4-MDPV and derivatives are successively being scheduled, each year novel analogs appear on market. This study aimed at examination direct comparison properties structural isomer 3,4-MDPV, namely 2,3-MDPV along with model...