A5028064400- Gut microbiota and health
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Infant Nutrition and Health
- Gastrointestinal motility and disorders
- Phytochemicals and Antioxidant Activities
- Gastroesophageal reflux and treatments
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Clinical Nutrition and Gastroenterology
- Biochemical Analysis and Sensing Techniques
- Infant Health and Development
- Celiac Disease Research and Management
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Pediatric health and respiratory diseases
- Animal Nutrition and Physiology
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Tea Polyphenols and Effects
University of Chile
2016-2025
Millennium Science Initiative
2019-2024
San Sebastián University
2019
Universidad Bernardo O'Higgins
2019
Universidad Autónoma del Estado de Hidalgo
2019
Faculty (United Kingdom)
2019
The University of Queensland
2015
Hospital San Borja Arriarán
1997
Hôpital Saint Lazare
1992
Inserm
1989-1992
The gut microbiota is currently recognized as an important factor regulating the homeostasis of gastrointestinal tract and influencing energetic metabolism host well its immune central nervous systems. Determining composition healthy subjects therefore necessary to establish a baseline allowing detection alterations in pathologic conditions. Accordingly, aim this study was characterize Chilean using 16S rRNA gene sequencing. Fecal samples were collected from 41 young, asymptomatic, normal...
The aim of this study was to determine the protective effect quercetin, epigallocatechingallate, resveratrol, and rutin against disruption epithelial integrity induced by indomethacin in Caco-2 cell monolayers. Indomethacin decreased transepithelial electrical resistance increased permeability monolayers fluorescein-dextran. These alterations were abolished all tested polyphenols but rutin, with quercetin being most efficient. associated its capacity inhibit redistribution ZO-1 protein tight...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex disorder whose prevalence rapidly growing in South America. The disturbances the microbiota–gut–liver axis impact damaging processes toward fibrosis. Gut microbiota status shaped by dietary and lifestyle factors, depending on geographic location. We aimed to identify microbial signatures group of Chilean MASLD patients. Forty subjects were recruited, including healthy controls (HCs), overweight/obese (Ow/Ob),...
Background: Chronic nonsteroidal anti‐inflammatory drug (NSAID) ingestion strongly affects the gastrointestinal mucosa as a first stage before ulceration. Some Lactobacillus strains may stabilize mucosal barrier by increasing mucin expression, reducing bacterial overgrowth, stimulating immunity and synthetizing antioxidant substances; these events are altered in NSAID‐associated gastroenteropathy. Aim: To determine whether of probiotic GG (LGG) protects against indometacin‐induced...
Aliment Pharmacol Ther 2010; 32: 1307–1314 Summary Background Obesity is associated with low‐grade inflammation contributing to insulin‐resistance. Gut barrier alterations, described in animal models of obesity, probably favour inflammation. This has not been hitherto obese humans. Aim To evaluate gut permeability asymptomatic and its association plasma (C‐reactive protein (CRP), arachidonate/eicosapentaenoate ratio) faecal (calprotectin leptin) markers microbiota alterations. Methods A...
OBJECTIVES: High-fat diets alter gut microbiota and barrier function, inducing metabolic endotoxemia low-grade inflammation. Whether these effects are due to the high dietary lipid content or concomitant decrease of carbohydrate intake is unclear. The aim this study was determine whether higher amounts fat reaching colon (through orlistat administration) affect colonic ecosystem in healthy volunteers effect prebiotic oligofructose (OF) model. METHODS: Forty-one young subjects were...
The nutraceutical properties of Aloe vera have been attributed to a glucomannan known as acemannan. Recently information has published about the presence fructans in but there are no publications acemannan and prebiotic compounds. This study investigated vitro these polysaccharides. Our results demonstrated that from induced bacterial growth better than inulin (commercial FOS). Acemannan stimulated less fructans, much commercial FOS. Using qPCR population human feces fermented bioreactor...
The protective effect of proanthocyanidin-containing polyphenol extracts from apples, avocados, cranberries, grapes, or proanthocyanidin microbial metabolites was evaluated in colonic epithelial cells exposed to p-cresol, a deleterious compound produced by the microbiota l-tyrosine. In HT29 Glc(-/+) cells, p-cresol significantly increased LDH leakage and decreased ATP contents, whereas Caco-2 cell monolayers, it transepithelial electrical resistance paracellular transport FITC-dextran....