A5102778667- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Chemical Thermodynamics and Molecular Structure
- Metabolomics and Mass Spectrometry Studies
- Fault Detection and Control Systems
- Heat and Mass Transfer in Porous Media
- Advanced Sensor and Control Systems
- Hydrocarbon exploration and reservoir analysis
- Process Optimization and Integration
- Control Systems in Engineering
- Sepsis Diagnosis and Treatment
- Machine Learning in Materials Science
- Genomics, phytochemicals, and oxidative stress
- Crystal structures of chemical compounds
- Advanced Algorithms and Applications
- Enhanced Oil Recovery Techniques
- Erythrocyte Function and Pathophysiology
- Advanced Physical and Chemical Molecular Interactions
- Glutathione Transferases and Polymorphisms
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Genomic variations and chromosomal abnormalities
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2024
Guangdong University of Petrochemical Technology
2022
China Academy of Chinese Medical Sciences
2021-2022
Zhengzhou University
2015
Henan Cancer Hospital
2015
Tenoxicam (TNX) is a new non-steroidal anti-inflammatory drug that shows superior effect and has the advantages of long half-life period, fast onset action, small dose, complete metabolism, good tolerance. Some compounds often have tautomerism, different tautomers exist in crystalline forms. TNX such compound three tautomers. always exists as zwitterionic form cocrystals. When salt formed, enol form, which exhibits two conformations depending on whether proton gained or lost. Currently,...
Matrine (MAT), a natural Chinese herbal medicine, has unique advantage in the treatment of various chronic diseases. However, its low melting point, bioavailability, and high dosage restrict subsequent development into new drugs. In this study, three kinds MAT salts, namely, MAT-2,5-dihydroxybenzoic acid (MAT-25DHB), MAT-2,6-dihydroxybenzoic (MAT-26DHB), MAT-salicylic acid-hydrate (MAT-SAL-H
Cocrystals, as an excellent solid state to improve the physicochemical properties of active pharmaceutical ingredients, have always been discussed together with solvates since definition cocrystals was proposed. However, investigation and discussion boundary between not common. In this work, aiming at betulin (BE), a natural product multiple pharmacological activities, we designed its polymorphism cocrystal screening experiments different liquid organic solvents coformers (CCFs) that possess...
Betulin (BE) can be obtained from many plants, such as those belonging Betulaceae family, and pharmacological investigations showed its notable biological properties good potential for food pharmaceutical development. We investigated the homogeneity, stability, purity, uncertainty of a newly certified reference material (CRM) BE. The purity value CRM BE was 99.56% with an extended 0.07% (k = 2, P 0.95), determined by differential scanning calorimetry (DSC). In this study, DSC used first time...
The aim of this study was to evaluate the role GSTM1 null/present, GSTT1 and GSTP1 polymorphisms in clinical response chemotherapy treatment outcome breast cancer. GSTM1, GSTT1, IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. Conditional logistic regression analysis revealed that cancer patients carrying GG genotype showed a significantly better compared those expressing AA [odds ratio = 2.66, 95%...
Drospirenone (DE) is a fourth-generation progesterone that has been widely used in oral contraceptives for women because of its safety and few side effects terms pharmacological activity. A new solvatomorph (crystal form C) DE with dimethyl sulfoxide was identified characterized the first time through thermogravimetry–mass spectrometry (TG–MS) coupling system. The thermodynamic property different from those most pharmaceutical solvatomorphs, it revealed via skimmer-type interfaced TG–MS...
The traditional thermodynamic equation based on heat flow balance without reflecting the variation characteristics of reaction process. New thermodynamics energy conservation is established involving multiple complex factors with process, including species, matter mass and capacity. DSC/DTA acquired from differential equation. new reflects dynamic Kirchhoff's law expresses capacity integral term which both decided by progression. Two kinds modes CaCO3 reactions are carried out to verify...
Abstract Betulin (BE) has exceedingly become a potential natural product, providing multiple pharmacological and biological activities, including anti-cancer, anti-viral, anti-inflammatory benefits . Previous research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic solvents. This property directly affect its extraction, isolation, preparation process. In this study, system thermogravimetry (TG)–differential thermal analysis (DTA)...
To analyze the clinical phenotype and genomic abnormality of an adult featuring congenital heart defect multiple developmental disorders.The patient was subjected to conventional G-banding chromosomal karyotyping single nucleotide polymorphism microarray (SNP-array) analysis.The showed a normal karyotype, while SNP-array revealed 42.7 Mb mosaic uniparental disomy (UPD) in 11p15.5p12 region ([hg19] chr11: 491 333-43 189 376).The mosaicism UPD probably underlies disorders patient.