A5031272880- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Nigella sativa pharmacological applications
- Insect Utilization and Effects
- Child and Adolescent Psychosocial and Emotional Development
- Glioma Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Statistical Methods in Clinical Trials
- Sepsis Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Adenosine and Purinergic Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Insect symbiosis and bacterial influences
- Cancer Mechanisms and Therapy
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Cancer, Stress, Anesthesia, and Immune Response
- Adventure Sports and Sensation Seeking
- COVID-19 Clinical Research Studies
- Bioactive Compounds and Antitumor Agents
- Biofield Effects and Biophysics
- Histone Deacetylase Inhibitors Research
- Media Influence and Health
- Youth Substance Use and School Attendance
Charleston Area Medical Center
2009-2025
Center for Cancer Research
2018-2024
West Virginia University
2009-2022
University of Charleston
2017-2022
Clinical Research Consulting
2022
CAMC Health Education and Research Institute
2021
Virginia Tech
2009
Glioblastoma multiforme (GBM), the most prevalent primary malignant brain tumor in adults, exhibits a dismal 6.9% five-year survival rate post-diagnosis. Thymoquinone (TQ), abundant bioactive compound Nigella sativa , has been extensively researched for its anticancer properties across various human cancers. However, specific anti-cancer mechanisms and pathways glioblastoma remain to be completely elucidated. In this study, we assessed impact of different TQ concentrations on viability A172...
The study aim was to determine how peripheral trigeminal nerve injury affects mitochondrial respiration and test efficacy of combined treatment with 2 Federal Drug Administration approved drugs potential for improving bioenergetics, pain anxiety-related behaviors in a chronic orofacial neuropathic mouse model.Efficacy (R)-(+)-4-amino-3-isoxazolidinone (D-cycloserine, DCS), an N-Methyl-D-aspartate antagonist/agonist, Pioglitazone (PIO), selective agonist nuclear receptor peroxisome...
The habanero pepper (
Distress tolerance, the degree to which one is able cope with and endure negative emotional states, has been broadly applied understand treat a variety of health (including behavioral) problems, but little known about its role in oral care specifically dental care-related fear anxiety, making it novel construct literature. This cross-sectional study examined distress tolerance as possible predictor anxiety among sample adults without diagnoses phobia, investigated differences levels between...
Glioblastoma multiforme (GBM), the most prevalent primary malignant brain tumor in adults, exhibits a dismal 6.9% five-year survival rate post-diagnosis. Thymoquinone (TQ), abundant bioactive compound Nigella Sativa, has been extensively researched for its anti-cancer properties across various human cancers. Yet, specific anticancer mechanisms and pathways glioblastoma remain to be elucidated. In this study, we assessed impact of different TQ concentrations on viability A172 cells using...
Chili peppers are an important constituent of many foods and contain medicinally valuable compounds, such as capsaicin dihydrocapsaicin. As various dietary botanicals have anticancer properties, this study was aimed to examine the effect Ghost pepper (Bhut Jolokia), one hottest chili in world, on cell proliferation, apoptosis, senescence global proteomic profile human renal adenocarcinoma vitro. 769-P cells were cultured RPMI-1640 media supplemented with fetal bovine serum (10%)...
The purpose of this study is to characterize D-cycloserine (DCS) physicochemical properties facilitate future formulation development DCS for anxiety disorders. A stability-indicating HPLC assay method the quantitation was developed and calibrated be used study. partition coefficient determined compared with predicted value. solution stability studied under various pH (2.0-11.5) ionic strengths 10 20 mM at physiological temperature 37°C. 250 mg capsule compounded nominal strength 50 These...
Hydroxychloroquine (HCQ) for coronavirus disease 2019 (COVID-19) is presently being used off-label or within a clinical trial.We investigated multinational database of patients with COVID-19 real-world data containing outcomes and their relationship to HCQ use. The primary outcome was all-cause mortality 30 days follow-up.This retrospective cohort study receiving 48 hours hospital admission. Medications, preexisting conditions, measures on admission, were recorded.Among diagnosis in our...
One of the greatest impacts on gastrointestinal microbiome is diet because host and share same food source. In addition, effect can diverge depending genotype. Diets supplemented with phytochemicals found in peppers might cause shifts microbiome. Thus, understanding how these interactions occur reveal potential health implications associated such changes. This study aims to explore gut different Drosophila genetic backgrounds effects dietary pepper treatments its composition structure. We...
Brain metastases (BM) are associated with dismal prognosis, and there is a dearth of effective systemic therapy. In this study, patients BM from multiple solid tumors were identified TriNetX databases, their clinicopathological features evaluated, the effects immune checkpoint inhibitor (ICI) therapy assessed. Variables, including median overall survival (OS), Eastern Cooperative Oncology Group (ECOG) performance status, primary diagnosis, date retrieved TriNetX, real-world database....
Abstract Oil from Nigella sativa seeds (“black seed oil”) has been used for health care and medical purposes over 2000 years. The major active compound thymoquinone (TQ) shown to have immune regulatory effects in various diseases. Tumor microenvironment is critical tumor development. Immune cells, particularly T are central players kill cells affect progression metastasis. impact of TQ on human cell-mediated anti-tumor response was investigated. Using PBMCs, we activated with anti-CD3/CD28...
The Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument© (PD-AID) is a patient-reported outcome (PRO) instrument, recently developed to assess the clinical benefit (PD) treatment. PD-AID consists morning evening assessments, administered daily. To from full set repeated observations over time, analytic approaches that account for both within- between-individual variability are required. current study aimed employ advantages exploratory Multilevel Factor...