A5063382963- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Physiology in Livestock
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Plant nutrient uptake and metabolism
- Extracellular vesicles in disease
- Protist diversity and phylogeny
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Metalloenzymes and iron-sulfur proteins
- Plant Disease Resistance and Genetics
- Chemical Reactions and Isotopes
- Pregnancy and preeclampsia studies
University of Oxford
2019-2021
John Radcliffe Hospital
2021
National Chiayi University
2012
Academia Sinica
2012
University of Chicago
2012
Abstract To study the regulatory and functional differentiation between mesophyll (M) bundle sheath (BS) cells of maize (Zea mays), we isolated large quantities highly homogeneous M BS from newly matured second leaves for transcriptome profiling by RNA sequencing. A total 52,421 annotated genes with at least one read were found in two transcriptomes. Defining a gene more than per kilobase million mapped reads as expressed, identified 18,482 expressed genes; 14,972 cells, including 53...
ABSTRACT Extracellular vesicles are highly abundant in seminal fluids and have a known role enhancing sperm function. Clinical pregnancy rates after IVF treatment improved female exposure to fluid. Seminal fluid extracellular (SF‐EVs) candidate enhancers, however, whether SF‐EVs interact with cells from the endometrium modulate implantation processes is unknown. Here, we investigated endometrial stromal (ESCs) enhance decidualisation, requisite for implantation. SF‐EVs, isolated human ( n =...
Recurrent Pregnancy Loss (RPL) affects 2-4% of couples, and with increasing numbers pregnancy losses the risk miscarrying a euploid is increased, suggesting RPL pathology distinct from sporadic miscarriage that due largely to lethal embryonic aneuploidy. There are number conditions associated including unspecified "immune" pathologies; one strongest candidates for dysregulation remains T regulatory cells as depletion in very early stages mice leads loss. Human endometrial Treg conventional...
The human endometrium is the innermost mucosal membrane of uterus and first point contact for an implanting blastocyst. A wide variety immune cells are found amongst endometrial epithelial layers stromal which both provide host responses against pathogens also assist with placentation pregnancy establishment, however, B have not been characterized, despite being a vital player in adaptive immunity. Through analysis mid-luteal biopsies, we find 1–5% cells, majority were naïve or memory few...
Abstract Recurrent Pregnancy Loss (RPL) affects 2-4% of couples, and with increasing numbers pregnancy losses the risk miscarrying a euploid is increased, suggesting RPL pathology distinct from sporadic miscarriage that due largely to lethal embryonic aneuploidy. There are number conditions associated including unspecified ‘immune’ pathologies, one strongest candidates for dysregulation remains T regulatory cells as depletion in very early stages mice leads loss. Human endometrial Treg...