A5089437901- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Polydiacetylene-based materials and applications
- Electrospun Nanofibers in Biomedical Applications
- Pickering emulsions and particle stabilization
- Hydrogels: synthesis, properties, applications
- Connective tissue disorders research
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- 3D Printing in Biomedical Research
- Electrochemical sensors and biosensors
- DNA and Nucleic Acid Chemistry
- Tissue Engineering and Regenerative Medicine
- Photochromic and Fluorescence Chemistry
- Click Chemistry and Applications
- Herpesvirus Infections and Treatments
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Lipid Membrane Structure and Behavior
- Influenza Virus Research Studies
- Machine Learning in Materials Science
- Conducting polymers and applications
- Graphene and Nanomaterials Applications
- COVID-19 Impact on Reproduction
- Molecular Junctions and Nanostructures
Max Planck Institute for Polymer Research
2018-2024
Universität Ulm
2017-2021
Max Planck Society
2019
Abstract Nucleic acids are gaining significant attention as versatile building blocks for the next generation of soft materials. Due to advances in chemical synthesis and biotechnological production, DNA becomes more widely available enabling its usage bulk material various applications. This has prompted researchers actively explore unique features offered by DNA‐containing materials like hydrogels. In this review article, recent developments field hydrogels that feature a component either...
Abstract In osteoporosis, bone structure can be improved by the introduction of therapeutic molecules inhibiting resorption osteoclasts. Here, biocompatible hydrogels represent an excellent option for delivery pharmacologically active to tissue because their biodegradability, injectability, and manifold functionalization capacity. The present study reports preparation a multifunctional hybrid hydrogel from chemically modified human serum albumin rationally designed DNA building blocks....
Abstract The synthesis of hybrid hydrogels by pH‐controlled structural transition with exceptional rheological properties as cellular matrix is reported. “Depsi” peptide sequences are grafted onto a polypeptide backbone that undergo pH‐induced intramolecular O–N–acyl migration at physiological conditions affording nanofibers (PNFs) supramolecular gelators. polypeptide–PNF mechanically remarkably robust. They reveal exciting thixotropic behavior immediate in situ recovery after exposure to...
The development of a synthetic code that enables sequence programmable feature like DNA represents key aspect toward intelligent molecular systems. We developed herein the well-known dynamic covalent interaction between boronic acids (BAs) and catechols (CAs) into nucleobase analogs. Along defined peptide backbone, BA or CA residues are arranged to enable recognition their complementary strand. Dynamic strand displacement errors were elucidated thermodynamically show sequences able...
The placenta acts as physical and immunological barrier against the transmission of viruses bacteria from mother to fetus. However, specific mechanisms by which protects developing fetus viral bacterial pathogens are poorly understood. To identify placental peptides small proteins protecting infections, we generated a peptide library 10 kg chromatographic means. Screening resulting 250 fractions Herpes-Simplex-Virus 2 (HSV-2), is rarely transmitted through placenta, in cell-based system...
Responsive biomaterials, tunable from the molecular to macroscopic scale, are attractive for various applications in nanotechnology. Herein, a long polypeptide chain derived abundant serum protein human albumin is cross-linked by dynamic-coordinative iron(III)/catechol bonds. By tuning binding stoichiometry and pH, reversible intramolecular folding into nanoparticles with controllable sizes achieved. Moreover, upon varying stoichiometry, intermolecular cross-links become predominant yielding...
Amyloid-like fibrils are a special class of self-assembling peptides that emerge as promising nanomaterial with rich bioactivity for applications such cell adhesion and growth. Unlike the extracellular matrix, intrinsically stable amyloid-like do not respond nor adapt to stimuli their natural environment. Here, motif (CKFKFQF), in which photosensitive o-nitrobenzyl linker (PCL) is inserted, designed. This peptide (CKFK-PCL-FQF) assembles into comparable unsubstituted CKFKFQF reveals strong...
First synthesis of alkynylated poly(dithieno[3,2-<italic>b</italic>:2′,3′-<italic>d</italic>]pyrroles) is reported for the fabrication compositionally tuneable electrodes.
Controlling the assembly and disassembly of cross-β-sheet-forming peptides is one predominant challenges for this class supramolecular material. As they constitute a continuously propagating material, every atomic change can be exploited to bring about distinct responses at architectural level. We report herein that, by using rational chemical design, serine methionine both used as orthogonal triggers signal assembly/disassembly through their corresponding stimuli. Serine construct an...
Responsive biomaterials, tunable from the molecular to macroscopic scale, are attractive for various applications in nanotechnology. Herein, a long polypeptide chain derived abundant serum protein human albumin was cross-linked by dynamic-coordinative iron(III)/catechol bonds. By tuning binding stoichiometry and pH, reversible intramolecular folding into nanoparticles with controllable sizes achieved. Moreover, upon varying stoichiometry, intermolecular cross-links became predominant...
The assembly and disassembly of the oligopeptide KIKISQINM is independently controlled by two different external stimuli. process involves kosmotrope-induced hydrolysis a phenylboronic acid–carbamate cage followed an intramolecular O,N-acyl shift to release fibrilizing oligopeptide. On demand, cross-β-sheet structure can be disassembled oxidation thioether residues (methionine) in presence hydrogen peroxide. This work broadens chemical tools design concepts for controlling supramolecular...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes"Marco HebelMarco HebelMore by Marco Hebel, Andreas RieggerAndreas RieggerMore Riegger, Maksymilian M. ZegotaMaksymilian ZegotaMore Zegota, Gönül KizilsavasGönül KizilsavasMore Kizilsavas, Jasmina GačaninJasmina GačaninMore Gačanin, Michaela PieszkaMichaela PieszkaMore Pieszka, Thorsten LückerathThorsten...
Amyloid-like fibrils are a special class of self-assembling peptides that have emerged as promising nanomaterial with rich bioactivity for applications such cell adhesion and growth. Unlike the extracellular matrix, intrinsically stable amyloid-like do not respond nor adapt to stimuli their natural environment. Here, we designed motif (CKFKFQF), in which photosensitive o-nitrobenzyl linker (PCL) was inserted. This peptide (CKFK-PCL-FQF) assembled into comparable unsubstituted CKFKFQF...
Responsive biomaterials, tunable from the molecular to macroscopic scale, are attractive for various applications in nanotechnology. Herein, a long polypeptide chain derived abundant serum protein human albumin was cross-linked by dynamic-coordinative iron(III)/catechol bonds. By tuning binding stoichiometry and pH, reversible intramolecular folding into nanoparticles with controllable sizes achieved. Moreover, upon varying stoichiometry, intermolecular cross-links became predominant...